DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-2 and Tcirg1

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001129563.1	Gene:	Tcirg1 / 27060	MGIID:	1350931	Length:	834	Species:	Mus musculus

Alignment Length:	859	Identity:	361/859 - (42%)
Similarity:	516/859 - (60%)	Gaps:	65/859 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||.||||||:||.|:.:...:||..||:|||.|.|:|||||.:|:||||:||.:||||:|||:..
Mouse     1 MGSMFRSEEVALVQLLLPTGSAYNCVSQLGELGLVEFRDLNESVSAFQRRFVVDVRRCEELEKTF 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            .::..|:::.|:.|...:..:| ||.||:::.::...::...|:.::..|:..:::...:|....
Mouse    66 TFLREEVQRAGLTLAPPEGTLP-APPPRDLLRIQEETDRLAQELRDVRGNQQALRAQLHQLRLHS 129

  Fly   131 KVL----------ENTQGFFSDQEVLNLDSSNRAGGDNDAAAQHRGRLGFVAGVINRERVFAFER 185
            .||          ::|:|.||:...|   .....|..:|.      ::.||||.:...:..|.||
Mouse   130 AVLGQSHSPPVAADHTEGPFSETTPL---LPGTRGPHSDL------KVNFVAGAVEPYKAAALER 185

  Fly   186 MLWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSS 250
            :|||..||.:.....:.:..|.||.||.|.....||..:.|||:..:|:|:...||..::|....
Mouse   186 LLWRACRGFLIASFRETEGQLEDPVTGEPATWMTFVISYWGEQIGQKIRKITDCFHCHVFPYLEQ 250

  Fly   251 HNEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVT 315
            ...|...::.::.:.::|:.||.:|:...|:||..|.:.||.|.:.:.||||:|.|||..:::.|
Mouse   251 EEARFRTLQQLQQQSQELQEVLGETDRFLSQVLGRVQQLLPPWQVQIHKMKAVYLTLNQCSVNTT 315

  Fly   316 KKCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDA 380
            .||||.|.|....|||.||:||..||:..|  :.:..:.|...:.|||..|||:||..||.::||
Mouse   316 HKCLIAEVWCAARDLPTVQQALQSGSSEEG--VSAVAHRIPCQDMPPTLIRTNRFTSSFQGIVDA 378

  Fly   381 YGVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFG 445
            |||..|||.|||.||.|||||||||||||:||||::.||...|||.|.:.|......|||..|||
Mouse   379 YGVGRYREVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMVLTENRPAVKAAQNEIWQTFFG 443

  Fly   446 GRYIILLMGLFAMYTGLVYNDVFSKSMNLFGSRWFNNYNTTTVLTNPN------------LQLPP 498
            |||::||||||::|||.:||:.||::..:|.|.|     :...:.|.:            |.|.|
Mouse   444 GRYLLLLMGLFSVYTGFIYNECFSRATTIFPSGW-----SVAAMANQSGWSDEYLSQHSMLTLNP 503

  Fly   499 NSSAV--GVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIF 561
            |.:.|  |.||||:||:|.||.|.:.||||||||:|:|.||.||.|||.:|:.|..||.:...:.
Mouse   504 NITGVFLGPYPFGIDPIWSLATNHLSFLNSFKMKMSVILGVTHMAFGVFLSIFNHVHFGQAHRLL 568

  Fly   562 LEFVPQILFLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCN 626
            ||.:|:::|||.||||:||::.:||.:.:|.::      ..|||:||.||||.||....    .|
Mouse   569 LETLPELIFLLGLFGYLVFLIVYKWVNVSAASA------SSAPSILIHFINMFLFSQNP----TN 623

  Fly   627 EFMFESQPQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAH-----ANHNGQLTGNIELAEGET 686
            ..:|..|..:|...|::||..:|.:|||.|||:....:::.:     |....:.|..:..:...:
Mouse   624 HLLFHGQEVVQYVLVVLALATVPILLLGTPLYLLRQHRHRRNTQRRPAGQQDEDTDKLLASPDAS 688

  Fly   687 PLPTGFSGNEENAGGAHGHDDEPM-SEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSE 750
            .|...:|.:||.||.....:.|.: |||::||||||||:.|..||:|||||||||||||||||||
Mouse   689 TLENSWSPDEEKAGSPGDEETEFVPSEIFMHQAIHTIEFCLGCISNTASYLRLWALSLAHAQLSE 753

  Fly   751 VLWQMVLSLGLKMSGVGGAIG-----LFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSK 810
            |||.||:.:||   |:|..||     |..:|.|:.:.|:|||::|||||||||.||||||||.:|
Mouse   754 VLWAMVMRIGL---GMGREIGVAAVVLVPVFAAFAVLTVAILLVMEGLSAFLHALRLHWVEFQNK 815

  Fly   811 FYEGMGYAFQPFSF 824
            ||.|.||...||:|
Mouse   816 FYSGTGYKLSPFTF 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	345/830 (42%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	342/825 (41%)
Tcirg1	NP_001129563.1	NtpI	27..829	CDD:224188	346/831 (42%)
Tcirg1	NP_001129563.1	V_ATPase_I	28..829	CDD:279793	345/830 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830