DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-2 and vph1

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_594219.2	Gene:	vph1 / 2542310	PomBaseID:	SPAC16E8.07c	Length:	831	Species:	Schizosaccharomyces pombe

Alignment Length:	861	Identity:	339/861 - (39%)
Similarity:	491/861 - (57%)	Gaps:	77/861 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKIRYI 68
            :|||||::|.|:::..|:|...:|.|||...:.|:|||.:|.||||.||.|:||..:.||.:||:
pombe     5 LFRSEEVSLVQLYLPTESARPIMSALGELSTIHFKDLNPDVVAFQRSFVREIRRLTDTERLLRYL 69

  Fly    69 ETEIKKDGIVLPDIQDDIPRAPNPREII------DLEAHLEKTESEMIELAQNEVNMKSNYLELT 127
            .:||..:||.:||  .::|  |:...::      |:...:.:.|:.:.:|.::...:::.||:..
pombe    70 HSEIDLNGIHVPD--HNLP--PSYESVLESSTIEDIIERITRLEARVRQLVESSQLLEARYLQQL 130

  Fly   128 ELRKVLENTQGFFS------DQEVLNLDSSNRAGGDNDAAA----------------------QH 164
            |...||.....|||      |....|.::|:...|::|..|                      |.
pombe   131 EFANVLTKADAFFSKSGNTVDPLRNNYETSSIFSGEDDTTAPLIENALELGTTGTFDSEETSPQM 195

  Fly   165 RGRLGFVAGVINRERVFAFERMLWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQL 229
            ...|.||:|:|...:....||:|||..|||:|:.:...|:.|...|..:. .||:|:....|.|:
pombe   196 NTTLDFVSGIIPTVKFQFLERILWRTLRGNLFIHQVRADDSLIHGAEKNE-EKTIFLVIAHGTQI 259

  Fly   230 KNRIKKVCTGFHASLYPCPSSHNEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWS 294
            ..||:|:.....|:|:|.......|...::.....:.||..||..|.......|..:::::.:|.
pombe   260 LLRIRKISESLGATLFPVEEDAPGRTSQIQQANVSISDLNAVLENTRSALYTELTFIAEHISAWE 324

  Fly   295 IMVKKMKAIYHTLNLFNMDVTKKCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNE 359
            .::.|.|.::..:||||.|...||||.|.|.||.:||:|||.|.:.|....|..|:.|||:.|:|
pombe   325 AVLHKDKTVFQVMNLFNYDQNHKCLIAEGWCPTANLPMVQKTLRNISDLTDSQAPTILNVVHTSE 389

  Fly   360 QPPTFNRTNKFTRGFQNLIDAYGVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMV 424
            ||||:.|.||||.|||::||:||:|:|||.|..:...:|||||||:||||||||.|:.......|
pombe   390 QPPTYFRVNKFTEGFQSIIDSYGIATYREVNHGIVAIVTFPFLFAIMFGDLGHGAIMASVALMFV 454

  Fly   425 LCERKLARIRNGGEIWNIFFGGRYIILLMGLFAMYTGLVYNDVFSKSMNLFGSRWFNNYNTTTVL 489
            |.|:.|...::..||..:.|.||||:||||||:||.|.||||:|||.|::|.|||.....:...:
pombe   455 LYEKTLGAKKDLDEIVGMVFYGRYIVLLMGLFSMYVGFVYNDLFSKPMSIFSSRWVWPVKSEEAI 519

  Fly   490 TNPNLQLPPNSSAVGVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHF 554
            .        .:..||.||.|:||.|..|||.::|:||:|||||||.||:||.|.:.:|:.|:..|
pombe   520 A--------RAVQVGTYPIGIDPTWHSADNNLLFMNSYKMKLSIILGVIHMTFCLFLSLSNYRFF 576

  Fly   555 KRYASIFLEFVPQILFLLLLFGYMVFMMFFKW-FSYNARTSFQPETPGCAPSVLIMFINMMLFKN 618
            ||...|:..|||.::||..:|||:|..:.:|| ..:.|: ..||      ||:|.|.|.|.|
pombe   577 KRKLDIYAVFVPSLIFLEAIFGYLVITIVYKWCIDWKAK-DLQP------PSLLNMLILMFL--- 631

  Fly   619 TEPPKGCNEFMFESQPQLQKAFVLIALCCIPWMLLGKP--LYIKFTRKNKAHANHNGQLTGNIEL 681
              .|....:.::..|..||...|:.||.|:||:|:.||  |:.:.:.:...:.:.|..|. |::.
pombe   632 --SPGTLEDQLYPGQKYLQVGLVIAALICVPWLLIVKPFVLWRRHSNEENKYQSLNSDLP-NVDE 693

  Fly   682 AEGETPLPTGFSGNEENAGGAHGHDDEP--MSEIYIHQAIHTIEYVLSTISHTASYLRLWALSLA 744
            |:....:    ...|:.|        ||  :.|:.|||.|||||:.|..:|||||||||||||||
pombe   694 ADALMAV----DSQEKQA--------EPFELGEVVIHQVIHTIEFCLGCVSHTASYLRLWALSLA 746

  Fly   745 HAQLSEVLWQMVLSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMS 809
            |.|||.|||.|.|:.|.:|:|:.|:|.:.|:||.|.:.|..:||.|||.||.||:|||||||.||
pombe   747 HNQLSSVLWNMTLANGFRMTGIVGSIFVVILFGFWFIATCVVLVAMEGTSAMLHSLRLHWVEGMS 811

  Fly   810 KFYEGMGYAFQPFSFK 825
            |.:||.||||.||:||
pombe   812 KHFEGEGYAFTPFTFK 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	327/834 (39%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	324/828 (39%)
vph1	NP_594219.2	NtpI	27..828	CDD:224188	330/839 (39%)
vph1	NP_594219.2	V_ATPase_I	29..826	CDD:279793	327/834 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	572	1.000	Domainoid score	I34
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	599	1.000	Inparanoid score	I160
OMA	1	1.010	-	-		QHG53812
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		otm47222
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
TreeFam	1	0.960	-	-
	12	11.830