DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-2 and Vha100-3

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	895	Identity:	320/895 - (35%)
Similarity:	492/895 - (54%)	Gaps:	87/895 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKIRYIE 69
            ||||:|.|||:.:..|.|:..:.|:|..|.|||.::..........:..:|.:|.||.|.:..:.
  Fly    15 FRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDSLH 79

  Fly    70 T---EIKKDGIVLPDI-------QDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYL 124
            |   ::..:.|..||:       :.|:.:..:..:.|.:||.........::..:|  .|..:..
  Fly    80 TYIVQLHVNEIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRN--RMMEHSF 142

  Fly   125 ELTELRKVLENTQG---FFSDQEVLNL--DSSNRAGGDNDAAAQHRGRLGFVAGVINRERVFAFE 184
            .|.:..|.:.:..|   .:|:..|:.|  |::..:|.       :...|.::.|.|..::.::||
  Fly   143 ALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGA-------YPAHLNYMIGCIRADKFYSFE 200

  Fly   185 RMLWRISRGNVFLKRSDLDEPLNDPATGHP---IYKTVFVAFFQGEQLKNRIKKVCTGFHASLYP 246
            .:|:|:...|:.::.|::..|:.:...|:.   :.|...:.......:..::.|:|..:|.::|.
  Fly   201 LLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYHVNIYD 265

  Fly   247 CPSSHNEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFN 311
            ||||.::||:.|:.:...:.:::.||.:.|..|.::|....::|....:.::|...:|..:|...
  Fly   266 CPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKALKVYDLMNRLR 330

  Fly   312 M----DVTKKCLIGECWVPTNDLPVVQKALSDGSAAVG----------------STIPS------ 350
            :    :| .:.|:.|.::|::|:|.|:..|.:.|...|                .|:|:
  Fly   331 LVGGVEV-PRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPNTTPYPI 394

  Fly   351 ---FLNVID-------------TNEQPPTFNRTNKFTRGFQNLIDAYGVASYRECNPALYTCITF 399
               |..:.|             .|..|||:.|.|||||||||||||||:|.|:|.|||.||.|||
  Fly   395 EADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYTIITF 459

  Fly   400 PFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIR----NGGEIWNIFFGGRYIILLMGLFAMYT 460
            ||||||||||||||::|:||.:.|:...|::.:.:    :..||.||.:.|||||||||:|::|.
  Fly   460 PFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGVFSVYM 524

  Fly   461 GLVYNDVFSKSMNLFGSRWFNNYNTTTVLTNPNLQLPPNSS-----AVGVYPFGMDPVWQL-ADN 519
            |||||.|.:|..|||||.|...||.|||. :|...:..:||     :...||.||||||.: ..:
  Fly   525 GLVYNIVMAKGFNLFGSSWSCRYNETTVY-DPAFHVTLDSSHPHFYSGHPYPLGMDPVWAVCGQD 588

  Fly   520 KIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQILFLLLLFGYMVFMMFF 584
            .|...||.|||::|:.|:..|:||:.::..|.....|.|.:.|..:||::|:|.||||:||::|:
  Fly   589 SITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFMLCLFGYLVFLIFY 653

  Fly   585 KWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFESQPQLQKAFVLIALCCIP 649
            ||.||..... .|....|||||||.||||||.|..:|.:.|.::|:.::..::.|.|.||.|.||
  Fly   654 KWMSYGGHKP-APYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMIEFALVGIAFCTIP 717

  Fly   650 WMLLGKPLYI-KFTRKNKAHANHNGQLTGNIELAEGETPLPTGFSGNEENA--GGAHGHDDEPMS 711
            .:|.|||:|: :..||.:.....:.:......:||..:.:......|.|.:  ......::..||
  Fly   718 ILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSRQKSVDNEEEHEMS 782

  Fly   712 EIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQMVLSLGL--KMSGVGGAIGLFI 774
            ||:||..|||||.||.::||||||||||||||||.|||:|||.|||:.|.  .:....|...|..
  Fly   783 EIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLTKGFANTLPLYYGVPVLMA 847

  Fly   775 IFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQPFSF 824
            .|.||.:.|:||||:||||||||||||||||||.|||:.|.|.:|:.|:|
  Fly   848 TFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKAFNF 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	309/870 (36%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	307/865 (35%)
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	309/870 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	P	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.700