Protein Alignment Vha100-2 and ATP6V0A2

DIOPT Version :10

• Sequence 1: NP_650722.1
• Gene: Vha100-2 / 42216
• FlyBaseID: FBgn0028670
• Length: 834
• Species: Drosophila melanogaster
• Sequence 2: NP_036595.2
• Gene: ATP6V0A2 / 23545
• HGNCID: 18481
• Length: 856
• Species: Homo sapiens
• Alignment Length: 873
• Identity: 390/873 - (44%)
• Similarity: 550/873 - (63%)
• Gaps: 74/873 - (8%)

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||.:||||.|.|.|:|:|...||..:|.|||.|.|||||||.||::||||||.||:||:||||.:
Human     1 MGSLFRSETMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERIL 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            .|:..||.:..|.||: .:..|.||..:::::::..|:|.|.|:.|:.:|:..::.|.|||.|..
Human    66 VYLVQEINRADIPLPE-GEASPPAPPLKQVLEMQEQLQKLEVELREVTKNKEKLRKNLLELIEYT 129

  Fly   131 KVLENTQGFF--------SDQEVLNLDSSNRAGGDNDAAAQHR--GRLGFVAGVINRERVFAFER 185
            .:|..|:.|.        :.:|..:|:|.:..    |.:...|  .:||||:|:||:.:|.|||:
Human   130 HMLRVTKTFVKRNVEFEPTYEEFPSLESDSLL----DYSCMQRLGAKLGFVSGLINQGKVEAFEK 190

  Fly   186 MLWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSS 250
            ||||:.:|...:..::|||.|.||.||..|...||:..|.|||:.:::||:|..:|..:||.|::
Human   191 MLWRVCKGYTIVSYAELDESLEDPETGEVIKWYVFLISFWGEQIGHKVKKICDCYHCHVYPYPNT 255

  Fly   251 HNEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVT 315
            ..||.|:...:.||::||..||.:|||:..:||...::::.|..|.|||||||||.||:.:.|||
Human   256 AEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVYSRVIQVKKMKAIYHMLNMCSFDVT 320

  Fly   316 KKCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDA 380
            .||||.|.|.|..||..:::||.:||...|:|||||:|:|.|.|.|||..||||||.||||::||
Human   321 NKCLIAEVWCPEADLQDLRRALEEGSRESGATIPSFMNIIPTKETPPTRIRTNKFTEGFQNIVDA 385

  Fly   381 YGVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFG 445
            |||.||||.||||:|.|||||||||||||.|||.::.||...:||.|.. .|:....||..:||.
Human   386 YGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENH-PRLNQSQEIMRMFFN 449

  Fly   446 GRYIILLMGLFAMYTGLVYNDVFSKSMNLFGSRW-----FNN------------YNTTTVLTNPN 493
            ||||:||||||::||||:|||.||||:|||||.|     :::            :|.:.|..|..
Human   450 GRYILLLMGLFSVYTGLIYNDCFSKSVNLFGSGWNVSAMYSSSHPPAEHKKMVLWNDSVVRHNSI 514

  Fly   494 LQLPPNSSAV--GVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKR 556
            |||.|:...|  |.||.|:||:|.||.|::.||||||||:|:|.|::||.|||.:.:.|..||::
Human   515 LQLDPSIPGVFRGPYPLGIDPIWNLATNRLTFLNSFKMKMSVILGIIHMTFGVILGIFNHLHFRK 579

  Fly   557 YASIFLEFVPQILFLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEP 621
            ..:|:|..:|::||:|.:|||::||:|:||..::|      ||...|||:||.||||.||
Human   580 KFNIYLVSIPELLFMLCIFGYLIFMIFYKWLVFSA------ETSRVAPSILIEFINMFLF----- 633

  Fly   622 PKGCNEFMFESQPQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKA--HANHNG----------- 673
            |......::..|..:|:..:::....:|.:.|||||::.:....::  ..|.:|
Human   634 PASKTSGLYTGQEYVQRVLLVVTALSVPVLFLGKPLFLLWLHNGRSCFGVNRSGYTLIRKDSEEE 698

  Fly   674 -QLTGNIELAEGETPLPTG---FSGNEENAGGAHGHDDEPMSEIYIHQAIHTIEYVLSTISHTAS 734
             .|.|:.::.||...:..|   .:..|.|.|           ||.:.|.||:|||.|..||:|||
Human   699 VSLLGSQDIEEGNHQVEDGCREMACEEFNFG-----------EILMTQVIHSIEYCLGCISNTAS 752

  Fly   735 YLRLWALSLAHAQLSEVLWQMVLSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHT 799
            |||||||||||||||:|||.|::.:||::....|.:.|..:...:.:.|:.||::|||||||||.
Human   753 YLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHA 817

  Fly   800 LRLHWVEFMSKFYEGMGYAFQPFSFKAI 827
            :|||||||.:|||.|.|..|.||||..:
Human   818 IRLHWVEFQNKFYVGAGTKFVPFSFSLL 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	27..824	CDD:460232	375/842 (45%)
ATP6V0A2	NP_036595.2	V_ATPase_I	27..842	CDD:460232	375/842 (45%)