Protein Alignment Vha100-2 and Atp6v0a2

DIOPT Version :10

• Sequence 1: NP_650722.1
• Gene: Vha100-2 / 42216
• FlyBaseID: FBgn0028670
• Length: 834
• Species: Drosophila melanogaster
• Sequence 2: NP_035726.2
• Gene: Atp6v0a2 / 21871
• MGIID: 104855
• Length: 856
• Species: Mus musculus
• Alignment Length: 887
• Identity: 394/887 - (44%)
• Similarity: 545/887 - (61%)
• Gaps: 102/887 - (11%)

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||.:||||.|.|.|:|:|...||..:|.|||.|.|||||||.||::||||||.||:||:||||.:
Mouse     1 MGSLFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERIL 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            .|:..||.:..|.||: .:..|.||..:.:::::..|:|.|.|:.|:.:|:..::.|.|||.|..
Mouse    66 VYLVQEITRADIPLPE-GEASPPAPPLKHVLEMQEQLQKLEVELREVTKNKEKLRKNLLELVEYT 129

  Fly   131 KVLENTQGF----------------FSDQEVLNLDSSNRAGGDNDAAAQHRGRLGFVAGVINRER 179
            .:|..|:.|                ..:..:|:.....|.|          .:||||:|:|.:.|
Mouse   130 HMLRVTKTFLKRNVEFEPTYEEFPALENDSLLDYSCMQRLG----------AKLGFVSGLIQQGR 184

  Fly   180 VFAFERMLWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASL 244
            |.||||||||..:|...:..::|||.|.||.||..|...||:..|.|||:.:::||:|..:|..:
Mouse   185 VEAFERMLWRACKGYTIVTYAELDECLEDPETGEVIKWYVFLISFWGEQIGHKVKKICDCYHCHI 249

  Fly   245 YPCPSSHNEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNL 309
            ||.|::..||.|:...:.||::||..||.:|||:..:||...::::.|..:.|:|||||||.||:
Mouse   250 YPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVCSRVVQVRKMKAIYHMLNM 314

  Fly   310 FNMDVTKKCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGF 374
            .:.|||.||||.|.|.|..|||.:::||.:||...|:|||||:|.|.|.|.|||..||||||.||
Mouse   315 CSFDVTNKCLIAEVWCPEVDLPGLRRALEEGSRESGATIPSFMNTIPTKETPPTLIRTNKFTEGF 379

  Fly   375 QNLIDAYGVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEI 439
            ||::|||||.||||.||||:|.|||||||||||||.|||.::.||...:||.|.. .|:....||
Mouse   380 QNIVDAYGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENH-PRLSQSQEI 443

  Fly   440 WNIFFGGRYIILLMGLFAMYTGLVYNDVFSKSMNLFGSRW-----FNN------------YNTTT 487
            ..:||.||||:||||||::||||:|||.||||:|||||.|     :::            :|.:|
Mouse   444 LRMFFDGRYILLLMGLFSVYTGLIYNDCFSKSVNLFGSGWNVSAMYSSSHSPEEQRKMVLWNDST 508

  Fly   488 VLTNPNLQLPPNSSAV--GVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVN 550
            :..:..|||.||...|  |.||||:||:|.||.|::.||||||||:|:|.|:.||.|||.:.:.|
Mouse   509 IRHSRTLQLDPNIPGVFRGPYPFGIDPIWNLATNRLTFLNSFKMKMSVILGIFHMTFGVVLGIFN 573

  Fly   551 FTHFKRYASIFLEFVPQILFLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMML 615
            ..||::..:::|..||:|||:|.:|||::||:.:||.:|:|.||.:      |||:||.||||.|
Mouse   574 HLHFRKKFNVYLVSVPEILFMLCIFGYLIFMIIYKWLAYSAETSRE------APSILIEFINMFL 632

  Fly   616 FKNTEPPKGCNEFMFESQPQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAHANHNGQ------ 674
            |     |......::..|..:|:..|.:.:..:|.:.|||||::.:.        |||:
Mouse   633 F-----PTSKTHGLYPGQAHVQRVLVALTVLAVPVLFLGKPLFLLWL--------HNGRNCFGMS 684

  Fly   675 ----------------LTGNIELAEGETPLPTG---FSGNEENAGGAHGHDDEPMSEIYIHQAIH 720
                            |.||.::.||.:.:..|   .:..|.|.|           ||.:.||||
Mouse   685 RSGYTLVRKDSEEEVSLLGNQDIEEGNSRMEEGCREVTCEEFNFG-----------EILMTQAIH 738

  Fly   721 TIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQMVLSLGLKMSGVGGAIGLFIIFGAWCLFTLA 785
            :|||.|..||:||||||||||||||||||:|||.|::.:||::....|.:.|..:...:.:.|:.
Mouse   739 SIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVMAFFAVLTIF 803

  Fly   786 ILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQPFSFKAI 827
            ||::|||||||||.:|||||||.:|||.|.|..|.||||..:
Mouse   804 ILLVMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLL 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	27..824	CDD:460232	379/856 (44%)
Atp6v0a2	NP_035726.2	V_ATPase_I	27..839	CDD:460232	377/853 (44%)