DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-2 and vha-5

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_501399.1	Gene:	vha-5 / 177626	WormBaseID:	WBGene00006914	Length:	873	Species:	Caenorhabditis elegans

Alignment Length:	882	Identity:	385/882 - (43%)
Similarity:	548/882 - (62%)	Gaps:	61/882 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||.:.|||||..||:.::.:||:..|:|:|:...|||:|||.|||:|||.||.::||.||:|||:
Worm     1 MGSLSRSEEMRFCQLIVEKDAAFNIVAEIGKQPYVQFKDLNPNVNSFQRTFVKDIRRYDEMERKL 65

  Fly    66 RYIETEIKKDGIVLPDIQD--DIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTE 128
            |::|::|.||.||:|...|  |....|. .|:..||..|.:.|.::..:..::..:|:|:::|.|
Worm    66 RFLESQIVKDEIVIPGRVDTGDYTILPT-SELNTLEGTLTELEKDVKSMNDSDSQLKANFMDLKE 129

  Fly   129 LRKVLENTQGFF-------SDQEVLNLDSSNRAGGDNDAAAQHRGRLGFVAGVINRERVFAFERM 186
            ...||:.|..||       :.:|:.|||.      :.......:|.:.::.|:|.|||:..|||:
Worm   130 WDAVLDKTDEFFQGGVDDQAQEELENLDE------EGAVPRVEKGPVNYLVGIIRRERLNGFERV 188

  Fly   187 LWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYP-CPSS 250
            |||......:::.||::|.|.||.||..::|:||:.|.:|:::::.::|||.||.|.|:. ||.:
Worm   189 LWRACHHTAYIRSSDIEEELEDPGTGEKVHKSVFIIFLKGDRMRSIVEKVCDGFKAKLFKNCPKT 253

  Fly   251 HNEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVT 315
            ..||:....:||.|::||:.||.||.:||.|||...:.|...|...|:.:|.::|.||||..|..
Worm   254 FKERQSARNDVRARIQDLQTVLGQTREHRFRVLQAAANNHHQWLKQVRMIKTVFHMLNLFTFDGI 318

  Fly   316 KKCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDA 380
            .:..:||||:|...:..|:||:..|:...||::...||:::|:..|||:|.|||||..||.::|:
Worm   319 GRFFVGECWIPLKHVEDVRKAIEVGAERSGSSVKPVLNILETSVTPPTYNETNKFTAVFQGIVDS 383

  Fly   381 YGVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFG 445
            ||:|:|||.|||.||.|||||||:.||||||||.|:::.|.|.||.|:.|.......||:|:|||
Worm   384 YGIATYRELNPAPYTIITFPFLFSCMFGDLGHGCIMLMAGLWFVLREKNLQARNIKDEIFNMFFG 448

  Fly   446 GRYIILLMGLFAMYTGLVYNDVFSKSMNLFGSRWFNNYNTTTVLTNPN---------LQLPPNSS 501
            |||||||||||:::.|::|||:|:||.|:|||.|.|.||.:.:....|         ::|.|..:
Worm   449 GRYIILLMGLFSIHAGIIYNDMFAKSFNIFGSGWKNPYNASEIEGWINRTEHGKEMLVELAPEDA 513

  Fly   502 ---AVGVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLE 563
               |.|.|.||:||:|.:|:||:.||||.|||||:|.|:..|.|||.:|..|.|:.|....||..
Worm   514 YDHAGGPYSFGVDPIWNIAENKLNFLNSMKMKLSVILGISQMTFGVILSFFNHTYNKSKIDIFTV 578

  Fly   564 FVPQILFLLLLFGYMVFMMFFKW--FSYNARTSFQPETPG--CAPSVLIMFINMMLFKN------ 618
            |:||:||:..:|.|:...:..||  |.....|.|....||  ||||:||..|||.:.|:
Worm   579 FIPQMLFMGCIFMYLCLQIILKWLFFWTKEATVFGQIYPGSHCAPSLLIGLINMFMMKDRNAGFV 643

  Fly   619 TEPPKGCNEF----------MFESQPQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAHANH-N 672
            .:..|...|:          .:..|..::...|:||:.|:|.||.|||::....:|.||...| |
Worm   644 VDGGKVNGEYREVETCYLSQWYPGQSVIEMILVVIAVICVPVMLFGKPIHHVMQQKKKAKELHGN 708

  Fly   673 GQLTGNIELAEGETPLPTGFSGNEENAGGAH------GHDDEPMSEIYIHQAIHTIEYVLSTISH 731
            ..:..|:.....|..|    :|..:..|.||      ||:||...:|.:|||||||||||..:||
Worm   709 ATVRANVVSDSSEIVL----NGGSKKEGAAHEEHGHGGHEDESFGDIMVHQAIHTIEYVLGCVSH 769

  Fly   732 TASYLRLWALSLAHAQLSEVLWQMV-LSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSA 795
            ||||||||||||||||||||||.|| ::.||.:||..|.|.::::|..:.:.|::||||||||||
Worm   770 TASYLRLWALSLAHAQLSEVLWHMVFVTGGLGISGTAGFIAVYVVFFIFFVLTISILVLMEGLSA 834

  Fly   796 FLHTLRLHWVEFMSKFYEGMGYAFQPFSFKAILDGEE 832
            ||||||||||||.||||.|:||.|.|:|||..|...|
Worm   835 FLHTLRLHWVEFQSKFYLGLGYPFVPYSFKTALQEAE 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	368/845 (44%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	367/839 (44%)
vha-5	NP_501399.1	V_ATPase_I	28..863	CDD:279793	368/845 (44%)
vha-5	NP_501399.1	NtpI	35..864	CDD:224188	367/839 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.780