DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-2 and unc-32

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001023017.1	Gene:	unc-32 / 176257	WormBaseID:	WBGene00006768	Length:	905	Species:	Caenorhabditis elegans

Alignment Length:	915	Identity:	444/915 - (48%)
Similarity:	582/915 - (63%)	Gaps:	97/915 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGD------------MFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVT 53
            |||            ::|||:|.|.|:::|.:|:|..|:||||.|.|||||||.:|::||||:|.
Worm     1 MGDYVTPGEEPPQPGIYRSEQMCLAQLYLQSDASYQCVAELGELGLVQFRDLNPDVSSFQRKYVN 65

  Fly    54 EVRRCDELERKIRYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVN 118
            |||||||:|||:||:|.|||||.|.:.|..:: |.||.|||:|||||..||.|:|:.|:.:||..
Worm    66 EVRRCDEMERKLRYLEREIKKDQIPMLDTGEN-PDAPLPREMIDLEATFEKLENELREVNKNEET 129

  Fly   119 MKSNYLELTELRKVLENTQGFFSDQE-----VLNLDSSNRAGG---------------DNDAAAQ 163
            :|.|:.|||||:.:|..||.||.:.:     :|...|..|...               |:|:||:
Worm   130 LKKNFSELTELKHILRKTQTFFEEVDHDRWRILEGGSGRRGRSTEREETRPLIDIGDMDDDSAAR 194

  Fly   164 HRG-----RLGFVAGVINRERVFAFERMLWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAF 223
            ...     |||||||||.|||:.||||:|||..||||||:.|::|:.|||..||.|:.|.||:.|
Worm   195 MSAQAAMLRLGFVAGVIQRERLPAFERLLWRACRGNVFLRTSEIDDVLNDTVTGDPVNKCVFIIF 259

  Fly   224 FQGEQLKNRIKKVCTGFHASLYPCPSSHNEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSK 288
            |||:.||.::||:|.||.|:|||||.:..||.||...|.||:||||.||.||:|||.|||...||
Worm   260 FQGDHLKTKVKKICEGFRATLYPCPDTPQERREMSIGVMTRIEDLKTVLGQTQDHRHRVLVAASK 324

  Fly   289 NLPSWSIMVKKMKAIYHTLNLFNMDVTKKCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLN 353
            |:..|...|:|:|:|||||||||:|||:||||.|.|.|..:|..::.||..|:...||.:||.||
Worm   325 NVRMWLTKVRKIKSIYHTLNLFNIDVTQKCLIAEVWCPIAELDRIKMALKRGTDESGSQVPSILN 389

  Fly   354 VIDTNEQPPTFNRTNKFTRGFQNLIDAYGVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVL 418
            .::|||.|||:|:|||||:||||::||||:|:|||.|||.||.|:|||||||||||:|||.|::|
Worm   390 RMETNEAPPTYNKTNKFTKGFQNIVDAYGIATYREINPAPYTMISFPFLFAVMFGDMGHGAIMLL 454

  Fly   419 FGAWMVLCERKLARIRNGGEIWNIFFGGRYIILLMGLFAMYTGLVYNDVFSKSMNLFGSRWFNNY 483
            ...:.:|.|::|...|...||:..||||||:|.|||.|::|||.:||||||||:|.|||.|.|..
Worm   455 AALFFILKEKQLEAARIKDEIFQTFFGGRYVIFLMGAFSIYTGFMYNDVFSKSINTFGSSWQNTI 519

  Fly   484 NTTTV--------LTNPNLQLPPNSSAVG-VYPFGMDPVWQLAD-NKIIFLNSFKMKLSIIFGVL 538
            ..:.:        .:...|.|||.::..| .||.|:||||.||: ||:.||||.|||:|::||:.
Worm   520 PESVIDYYLDDEKRSESQLILPPETAFDGNPYPIGVDPVWNLAEGNKLSFLNSMKMKMSVLFGIA 584

  Fly   539 HMVFGVCMSVVNFTHFKRYASIFLEFVPQILFLLLLFGYMVFMMFFKWFSYNA--RTSFQPETPG 601
            .|.|||.:|..||.:||....|...|:||::||..:|.|:...:..||..:.|  .|....:.||
Worm   585 QMTFGVLLSYQNFIYFKSDLDIKYMFIPQMIFLSSIFIYLCIQILSKWLFFGAVGGTVLGYKYPG 649

  Fly   602 --CAPSVLIMFINMMLFKNTEP----------PKGCNEFMFESQPQLQKAFVLIALCCIPWMLLG 654
              ||||:||..|||.:.|:...          |:......:..|..::...|::||..:|.||..
Worm   650 SNCAPSLLIGLINMFMMKSRNAGFVDDSGETYPQCYLSTWYPGQATIEIILVVLALVQVPIMLFA 714

  Fly   655 KPLYIKFTRKNK---------AHANHNGQLTGNIELAEGE-------TPLPTGFSGNEENAGGAH 703
            ||.::  .|::|         |.:|.:..:..:|...:.|       ||.|:|.         .|
Worm   715 KPYFL--YRRDKQQSRYSTLTAESNQHQSVRADINQDDAEVVHAPEQTPKPSGH---------GH 768

  Fly   704 GHDDEP--MSEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQMVLSLGLKMSGV 766
            ||.|.|  |.::.::|||||||:||..:||||||||||||||||||||:|||.||......:.|.
Worm   769 GHGDGPLEMGDVMVYQAIHTIEFVLGCVSHTASYLRLWALSLAHAQLSDVLWTMVFRNAFVLDGY 833

  Fly   767 GGAIG---LFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQPFSFKAIL 828
            .|||.   ||.|||:..:|   |||||||||||||.||||||||.||||.|:||.|.||||:.||
Worm   834 TGAIATYILFFIFGSLSVF---ILVLMEGLSAFLHALRLHWVEFQSKFYGGLGYEFAPFSFEKIL 895

  Fly   829 DGEEE 833
            ..|.|
Worm   896 AEERE 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	425/865 (49%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	421/859 (49%)
unc-32	NP_001023017.1	NtpI	40..892	CDD:224188	426/866 (49%)
unc-32	NP_001023017.1	V_ATPase_I	40..891	CDD:279793	425/865 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160170
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.810