Protein Alignment Vha100-2 and Atp6v0a4

DIOPT Version :9

• Sequence 1: NP_650722.1
• Gene: Vha100-2 / 42216
• FlyBaseID: FBgn0028670
• Length: 834
• Species: Drosophila melanogaster
• Sequence 2: NP_536715.3
• Gene: Atp6v0a4 / 140494
• MGIID: 2153480
• Length: 833
• Species: Mus musculus
• Alignment Length: 857
• Identity: 441/857 - (51%)
• Similarity: 581/857 - (67%)
• Gaps: 47/857 - (5%)

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            |..:||||||.|.|:|:|.||||..|:||||.|.|||:|||.|||:||||||.|||||:.|||.:
Mouse     1 MASVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLERIL 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            |::|.|::.:  :|..:.:.....|.|||:|.||..|||.|.|:.|..|:...:|.::||||||:
Mouse    66 RFLEDEMQNE--ILIQVPEKDAETPLPREMITLETTLEKLEGELQEANQSHQALKKSFLELTELK 128

  Fly   131 KVLENTQGFFSDQEVLNLDSSNRAGGDNDAAAQHR-------GRLGFVAGVINRERVFAFERMLW 188
            .:|:.||.||..:..|..|....   |.....:.|       |:|||.||||||||:.:|||:||
Mouse   129 YLLKKTQDFFETETNLGEDFFVE---DTSGLLELRTIPAFMTGKLGFTAGVINRERMASFERLLW 190

  Fly   189 RISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSHNE 253
            |:.||||:||.|::|..|.||.|...|.|.:|:.|:|||||:.:|||:|.||.|::||||....|
Mouse   191 RVCRGNVYLKFSEMDTLLEDPVTKEEIKKNIFIIFYQGEQLRLKIKKICDGFRATIYPCPEHAAE 255

  Fly   254 REEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTKKC 318
            |.||:.:|..|||||..|::|||.||.|:|...:.|..||.|.|:||||:||.||:.|:|||::|
Mouse   256 RREMLTSVNVRLEDLITVITQTESHRQRLLQEAAANWHSWVIKVQKMKAVYHVLNMCNIDVTQQC 320

  Fly   319 LIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAYGV 383
            :|.|.|.|..|...::|||..|....||::...:..::|...|||||||||||.||||::|||||
Mouse   321 IIAEIWFPVADTRHIKKALEQGMELSGSSMIPIMTEVETKTDPPTFNRTNKFTAGFQNIVDAYGV 385

  Fly   384 ASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGGRY 448
            .||||.|||.||.|||||||||||||.|||:::::...||||.||.|...::..|:|||||.|||
Mouse   386 GSYREINPAPYTIITFPFLFAVMFGDCGHGMVMLMAALWMVLNERHLLAQKSTNEMWNIFFNGRY 450

  Fly   449 IILLMGLFAMYTGLVYNDVFSKSMNLFGSRW-----FNN--YNTTTVLTNPNLQLPPNSSAV--- 503
            :|||||:|::||||:|||.||||.|:|||.|     |.|  :||..|..:|.|||.|....|
Mouse   451 LILLMGIFSIYTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWNTHIVENSPYLQLDPAIPGVYSG 515

  Fly   504 GVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQI 568
            ..||||:||:|.||.||:.||||:|||:|:|.|:.||:|||.:|:.|..:|:|..:|.|:|:|::
Mouse   516 NPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIAHMIFGVILSLFNHIYFRRTLNIILQFIPEM 580

  Fly   569 LFLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFESQ 633
            :|:|.||||:|||:.|||..|:|.||.:      |||:||.||.|.||...:   ..|..::..|
Mouse   581 IFMLSLFGYLVFMIIFKWCRYDAHTSRK------APSILIHFIGMFLFDYDD---SSNAPLYGHQ 636

  Fly   634 PQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAHANHNGQLTGNIELAEGETPLPTGFSG-NEE 697
            .::|..||:|||..:|||||.||    |..:.|...:.....|.:.:..||:      .|| :.:
Mouse   637 QEVQTFFVIIALVSVPWMLLIKP----FVLRAKHQKSQLQSFTIHEDAVEGD------HSGHSSK 691

  Fly   698 NAGGAH----GHDDE-PMSEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQMVL 757
            ...|||    ||::| ...:|::|||||||||.|..||:|||||||||||||||:||||||.||:
Mouse   692 KTAGAHGMKDGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAELSEVLWTMVM 756

  Fly   758 SLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQPF 822
            |:||::.|..|.:|:||||..:.:.|:|||::|||||||||.||||||||.:|||||.|..|.||
Mouse   757 SIGLRLQGWAGLVGVFIIFAVFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYEGAGSKFSPF 821

  Fly   823 SFKAILDGEEEE 834
            |||.:|:|..||
Mouse   822 SFKHVLEGTAEE 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	418/818 (51%)
		NtpI	35..825	CDD:224188	414/812 (51%)
Atp6v0a4	NP_536715.3	NtpI	28..824	CDD:224188	419/819 (51%)
		V_ATPase_I	28..823	CDD:279793	418/818 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	681..700		7/24 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H39904
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.790