DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-2 and Atp6v0a1

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_006532112.1	Gene:	Atp6v0a1 / 11975	MGIID:	103286	Length:	870	Species:	Mus musculus

Alignment Length:	893	Identity:	458/893 - (51%)
Similarity:	607/893 - (67%)	Gaps:	82/893 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||::||||||.|.|:|:|.||||..||||||.|.|||||||.:||.||||||.|||||:|::||:
Mouse     1 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKL 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            |::|.||:|..|.:.|..:: |..|.||::|||||:.||.|:|:.|:..|:..:|.|:||||||:
Mouse    66 RFVEKEIRKANIPIMDTGEN-PEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELK 129

  Fly   131 KVLENTQGFFSDQEVLN--------LDSSNRAGGDNDAAAQHRGRLGFVAGVINRERVFAFERML 187
            .:|..||.||.:.|:.:        |:.|:.....|:.......|||||||||||||:..|||||
Mouse   130 FILRKTQQFFDEAELHHQQMADPDLLEESSSLLEPNEMGRGAPLRLGFVAGVINRERIPTFERML 194

  Fly   188 WRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSHN 252
            ||:.||||||::::::.||.||.||..::|:||:.||||:|||||:||:|.||.|||||||.:..
Mouse   195 WRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQ 259

  Fly   253 EREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTKK 317
            ||:||...|.||::||::||:||||||.|||...:||:..|.|.|:|||||||||||.|:|||:|
Mouse   260 ERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQK 324

  Fly   318 CLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAYG 382
            |||.|.|.|..||..:|.||..|:...|||:||.||.:.||:.|||:|:|||||.||||::||||
Mouse   325 CLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTHGFQNIVDAYG 389

  Fly   383 VASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGGR 447
            :.:|||.|||.||.|||||||||||||.|||:::.||..||||.|.::...::..|::::.|.||
Mouse   390 IGTYREINPAPYTVITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKHENEMFSMVFSGR 454

  Fly   448 YIILLMGLFAMYTGLVYNDVFSKSMNLFGSRWF-------NNYNTTTVLTNPNLQLPPNSSAV-- 503
            |||||||||::||||:|||.||||:|:|||.|.       .|:...|:|.:..|||.|....|
Mouse   455 YIILLMGLFSIYTGLIYNDCFSKSLNIFGSSWSVRPMFTQGNWTEETLLGSSVLQLNPAIPGVFG 519

  Fly   504 GVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQI 568
            |.||||:||:|.:|.||:.||||||||:|:|.|::||:|||.:|:.|..:||:..:|:..|:|:|
Mouse   520 GPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEI 584

  Fly   569 LFLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFESQ 633
            :|:..||||:|.::|:||.:|:|.:|..      |||:||.||||.||..   |:..|..::..|
Mouse   585 IFMSSLFGYLVILIFYKWTAYDAHSSRN------APSLLIHFINMFLFSY---PESGNAMLYSGQ 640

  Fly   634 PQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAHANHNGQLTGNIELAEGE------TPLP--- 689
            ..:|...:::|:.|:|||||.|||.::.....|.|             .||:      ||.|
Mouse   641 KGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKH-------------LEGQPVEAPVTPTPSQQ 692

  Fly   690 --------TG---FSG-------NEENAG-------GAHGHD-DEPM-SEIY------IHQAIHT 721
                    ||   |.|       .||:|.       ..|..| :||. .|::      :||||||
Mouse   693 GLEAAPAATGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDAEEPTEDEVFDFGDTMVHQAIHT 757

  Fly   722 IEYVLSTISHTASYLRLWALSLAHAQLSEVLWQMVLSLGLKMSGVGGAIGLFIIFGAWCLFTLAI 786
            |||.|..||:||||||||||||||||||||||.||:.:||.:..:.|.:|||.||.|:...|:||
Mouse   758 IEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLHVRSLAGGLGLFFIFAAFATLTVAI 822

  Fly   787 LVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQPFSFKAILDGEEEE 834
            |::|||||||||.||||||||.:|||.|.|:.|.||||:.|.:|:.:|
Mouse   823 LLIMEGLSAFLHALRLHWVEFQNKFYTGTGFKFLPFSFEHIREGKFDE 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	435/854 (51%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	431/848 (51%)
Atp6v0a1	XP_006532112.1	V_ATPase_I	27..860	CDD:366676	436/855 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838555
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.670