DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-2 and atp6v0a4

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001107162.1	Gene:	atp6v0a4 / 100135019	XenbaseID:	XB-GENE-493197	Length:	846	Species:	Xenopus tropicalis

Alignment Length:	876	Identity:	439/876 - (50%)
Similarity:	582/876 - (66%)	Gaps:	72/876 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            |..:||||||:|.|:.:|.||.|..::||||.|.|||||||.:||:|||:||.|||||:.:||.:
Frog     1 MASLFRSEEMSLTQLILQVEAGYCCIAELGELGLVQFRDLNASVNSFQRRFVNEVRRCENMERIL 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            |::|:|:..|.|.: ...:.:|:.|.|||:||||..|||.|.|:.|:.:|:..:|.|:||||||:
Frog    66 RFLESEMVNDKIKI-RTPEKLPQTPLPREMIDLETVLEKLEGELQEVNRNQQALKQNFLELTELK 129

  Fly   131 KVLENTQGFFSDQ-----EVLNLDSSNRAGGDNDAAAQHRGRLGFVAGVINRERVFAFERMLWRI 190
            .:|:.||.||..:     :..:.|:|:........:|...|:|||.||||||||:..|||:|||:
Frog   130 HLLKKTQDFFEAEANLPDDFFSEDTSSLLELRTIPSAAAAGKLGFTAGVINRERMATFERLLWRV 194

  Fly   191 SRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSHNERE 255
            .|||::||.::||..|.||.|...:.|.||:.|:||:|||.:|||:|.||.|::||||.|..||:
Frog   195 CRGNIYLKYTELDTALEDPVTKEEVKKNVFIIFYQGDQLKLKIKKICDGFKATVYPCPESATERK 259

  Fly   256 EMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTKKCLI 320
            |||.:|.||:|||..|::|||.||.|||...:::|.||.|.||||||:||.|||.|:|||::|:|
Frog   260 EMVADVNTRIEDLNTVITQTESHRQRVLLEAAQSLCSWGIKVKKMKAVYHVLNLCNIDVTQQCVI 324

  Fly   321 GECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAYGVAS 385
            .|.|.|..|...:::||..|....||||...|..|.:...|||||||||||.||||:::||||.|
Frog   325 AEIWCPIADKEQIKQALHRGMERSGSTIAPILTNISSKLDPPTFNRTNKFTSGFQNIVNAYGVGS 389

  Fly   386 YRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGGRYII 450
            |||.||..||.|||||||||||||.|||.:::.|..||||.|::|...:...||||.||||||:|
Frog   390 YREMNPTPYTIITFPFLFAVMFGDCGHGSVMLGFALWMVLNEKQLLASKTDNEIWNTFFGGRYLI 454

  Fly   451 LLMGLFAMYTGLVYNDVFSKSMNLFGSRW-----FNNYNTTTVLTNPNLQLPPNSSAVGV----- 505
            |||.:|::|||.:|||.||||.::|||.|     |.|......|.:..|||..:.:..||
Frog   455 LLMSIFSIYTGFIYNDCFSKSFDIFGSSWRVRPMFINKTWNDNLVHQGLQLQLDPAVPGVYSGNP 519

  Fly   506 YPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQILF 570
            ||||:||:|.:|.||:.||||:|||:|::.|:..|||||.:.::|..:|||..:|.|:|||:::|
Frog   520 YPFGIDPIWNIAQNKLTFLNSYKMKMSVVMGITQMVFGVMLGLLNHINFKRPINIILQFVPEMIF 584

  Fly   571 LLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFESQPQ 635
            ::.||||:|||:.|||..|:..:|     .| |||:||.||||.||..::|   .|..::|.|.:
Frog   585 IICLFGYLVFMIIFKWCKYDVHSS-----QG-APSILIHFINMFLFNYSDP---TNAPLYEHQKE 640

  Fly   636 LQKAFVLIALCCIPWMLLGKPLYIK---------------------FTRKNKAHANHNGQLTGNI 679
            :|...|:.||..:|||||.||..::                     .|....|||||.
Frog   641 VQTFLVIFALIAVPWMLLIKPFVLRANHLKAQRMLQSSSGPEDHAELTDVENAHANHK------- 698

  Fly   680 ELAEGETPLPTGFSGNEENAGGAHG-----HDDE-PMSEIYIHQAIHTIEYVLSTISHTASYLRL 738
                         |..||:.||.||     |.:| ...:|::|||||||||.|..||:|||||||
Frog   699 -------------SKKEEHGGGDHGGGHGEHGEEFDFGDIFVHQAIHTIEYCLGCISNTASYLRL 750

  Fly   739 WALSLAHAQLSEVLWQMVLSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLRLH 803
            |||||||||||||||.||:..||.:.|.||.||:||||.|:.:.|:|||::|||||||||.||||
Frog   751 WALSLAHAQLSEVLWTMVMHQGLSIGGYGGLIGVFIIFAAFAVLTVAILLVMEGLSAFLHALRLH 815

  Fly   804 WVEFMSKFYEGMGYAFQPFSFKAILDGEEEE 834
            ||||.:|||.|.|:.|.||||::||:|.:.|
Frog   816 WVEFQNKFYAGTGHLFSPFSFQSILEGTDNE 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	420/837 (50%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	416/831 (50%)
atp6v0a4	NP_001107162.1	NtpI	26..838	CDD:224188	422/841 (50%)
atp6v0a4	NP_001107162.1	V_ATPase_I	28..836	CDD:279793	420/837 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H39904
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11629
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.110