DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-2 and tcirg1a

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_005160329.1	Gene:	tcirg1a / 100003139	ZFINID:	ZDB-GENE-090311-31	Length:	823	Species:	Danio rerio

Alignment Length:	852	Identity:	382/852 - (44%)
Similarity:	535/852 - (62%)	Gaps:	58/852 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||.:||||||.|.|:|:|..:||..||||||.|.|:|||||.||||||:|||:|||||:|||:..
Zfish     1 MGCLFRSEEMCLVQIFLQAGSAYNCVSELGELGLVEFRDLNPNVNAFQKKFVSEVRRCEELEKTF 65

  Fly    66 RYIETEIKKDGIVLPDIQ------DDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYL 124
            :|:|.||.:.  :.|.::      ..||.||.|||::.:|...|:...|:.|:::|..::::...
Zfish    66 KYLEQEISRS--LYPPLKGALPTASPIPSAPQPRELLCIEEESERLARELREVSRNRDSLRNQLT 128

  Fly   125 ELTELRKVLENTQGFFSDQ-EVLNLDSSNRAGGDNDAAAQHRGRLGFVAGVINRERVFAFERMLW 188
            :|::.|.||:.:....:.| ..|.|::|.......|.      ||.|||||::..:|.||||:||
Zfish   129 QLSQYRGVLKQSILLPTSQVPPLTLETSALLDSRQDM------RLSFVAGVVHPWKVPAFERLLW 187

  Fly   189 RISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSHNE 253
            |..||.:.:...:::|.|.:|.||..|..||||..|.|||:..::||:|..|....:..|....|
Zfish   188 RACRGYIIVDFWEMEERLEEPDTGETIQWTVFVISFWGEQIGQKVKKICDCFRTHTFVYPEGLEE 252

  Fly   254 REEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTKKC 318
            ||.:::.:.:|:.|::.||||||.:..::|:.....:|.|.|.|:|.||:...|||.:..||.||
Zfish   253 REGILQGLESRIVDIRTVLSQTEQYMQQLLSRCVCQMPQWKIRVQKCKAVQMVLNLCSPSVTDKC 317

  Fly   319 LIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAYGV 383
            ||.|.|.|...|.::|.||.:|:...||::.||.|.:.....|||...||.||..|||::|||||
Zfish   318 LIAEAWCPVAKLLLLQSALMEGTRKSGSSVDSFYNRLPAPTSPPTLFETNAFTSSFQNIVDAYGV 382

  Fly   384 ASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGGRY 448
            |||||.|||:||.|||||||||||||:||||::.|...||:|.||......:..|||.:.|||||
Zfish   383 ASYREVNPAVYTIITFPFLFAVMFGDVGHGLLMTLAALWMILEERDPKMRTSTNEIWRMLFGGRY 447

  Fly   449 IILLMGLFAMYTGLVYNDVFSKSMNLFGSRW-------FNNYNTTTVLTNPNLQLPPNSSAV--G 504
            :||:||||::|||.:||:.|||.::...|.|       ..|::..|:.:|..|.|.||.:.|  |
Zfish   448 LILMMGLFSIYTGAIYNECFSKGLSPVSSGWHLKPMIQHYNWSDETLRSNQYLTLDPNITGVFQG 512

  Fly   505 VYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQIL 569
            .||||:||:|.||:|.:.||||:|||:|:|.||:||.||||:|..|:.:|...:|:||..:|:::
Zfish   513 PYPFGIDPIWSLANNHLTFLNSYKMKMSVIIGVIHMTFGVCLSFFNYMYFGNVSSVFLVLIPELV 577

  Fly   570 FLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKN--TEPPKGCNEFMFES 632
            |:|.||||:|||:.|||.      :|.|:....|||:||.||:|.||..  :.||      ::..
Zfish   578 FMLCLFGYLVFMVVFKWI------AFGPQDSDRAPSILIHFIDMFLFSENPSNPP------LYPR 630

  Fly   633 QPQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAHANHNGQ---LTG----NIELAEGETPLPT 690
            |..:|:..|.:||..:|.:||||||.:.|..:|.....|..|   :|.    |.:|.:.|
Zfish   631 QMTVQRILVCLALLAVPVLLLGKPLQLYFQHRNSRRTLHEEQRSLVTDTSSINAQLVDLE----- 690

  Fly   691 GFSGNEENAGGAHGHDDEPMSEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQM 755
                    .||.....:...:|:::.||||||||.|..||:|||||||||||||||||:||||.|
Zfish   691 --------GGGGIDEQEFEWTEVFMQQAIHTIEYCLGCISNTASYLRLWALSLAHAQLAEVLWVM 747

  Fly   756 VLSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQ 820
            |:.:.|...|..|::.|.::|..:...|::||::|||||||||.||||||||.:|||.|.||.|.
Zfish   748 VMRISLSWQGYVGSVVLSVVFSLFATLTVSILLVMEGLSAFLHALRLHWVEFQNKFYRGSGYKFN 812

  Fly   821 PFSFKAI 827
            ||||::|
Zfish   813 PFSFESI 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	363/820 (44%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	359/814 (44%)
tcirg1a	XP_005160329.1	NtpI	5..818	CDD:224188	379/845 (45%)
tcirg1a	XP_005160329.1	V_ATPase_I	28..816	CDD:279793	363/820 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.830