Protein Alignment Vha100-2 and tcirg1a

DIOPT Version :10

• Sequence 1: NP_650722.1
• Gene: Vha100-2 / 42216
• FlyBaseID: FBgn0028670
• Length: 834
• Species: Drosophila melanogaster
• Sequence 2: XP_005160329.1
• Gene: tcirg1a / 100003139
• ZFINID: ZDB-GENE-090311-31
• Length: 823
• Species: Danio rerio
• Alignment Length: 852
• Identity: 382/852 - (44%)
• Similarity: 535/852 - (62%)
• Gaps: 58/852 - (6%)

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||.:||||||.|.|:|:|..:||..||||||.|.|:|||||.||||||:|||:|||||:|||:..
Zfish     1 MGCLFRSEEMCLVQIFLQAGSAYNCVSELGELGLVEFRDLNPNVNAFQKKFVSEVRRCEELEKTF 65

  Fly    66 RYIETEIKKDGIVLPDIQ------DDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYL 124
            :|:|.||.:.  :.|.::      ..||.||.|||::.:|...|:...|:.|:::|..::::...
Zfish    66 KYLEQEISRS--LYPPLKGALPTASPIPSAPQPRELLCIEEESERLARELREVSRNRDSLRNQLT 128

  Fly   125 ELTELRKVLENTQGFFSDQ-EVLNLDSSNRAGGDNDAAAQHRGRLGFVAGVINRERVFAFERMLW 188
            :|::.|.||:.:....:.| ..|.|::|.......|.      ||.|||||::..:|.||||:||
Zfish   129 QLSQYRGVLKQSILLPTSQVPPLTLETSALLDSRQDM------RLSFVAGVVHPWKVPAFERLLW 187

  Fly   189 RISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSHNE 253
            |..||.:.:...:::|.|.:|.||..|..||||..|.|||:..::||:|..|....:..|....|
Zfish   188 RACRGYIIVDFWEMEERLEEPDTGETIQWTVFVISFWGEQIGQKVKKICDCFRTHTFVYPEGLEE 252

  Fly   254 REEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTKKC 318
            ||.:::.:.:|:.|::.||||||.:..::|:.....:|.|.|.|:|.||:...|||.:..||.||
Zfish   253 REGILQGLESRIVDIRTVLSQTEQYMQQLLSRCVCQMPQWKIRVQKCKAVQMVLNLCSPSVTDKC 317

  Fly   319 LIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAYGV 383
            ||.|.|.|...|.::|.||.:|:...||::.||.|.:.....|||...||.||..|||::|||||
Zfish   318 LIAEAWCPVAKLLLLQSALMEGTRKSGSSVDSFYNRLPAPTSPPTLFETNAFTSSFQNIVDAYGV 382

  Fly   384 ASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGGRY 448
            |||||.|||:||.|||||||||||||:||||::.|...||:|.||......:..|||.:.|||||
Zfish   383 ASYREVNPAVYTIITFPFLFAVMFGDVGHGLLMTLAALWMILEERDPKMRTSTNEIWRMLFGGRY 447

  Fly   449 IILLMGLFAMYTGLVYNDVFSKSMNLFGSRW-------FNNYNTTTVLTNPNLQLPPNSSAV--G 504
            :||:||||::|||.:||:.|||.::...|.|       ..|::..|:.:|..|.|.||.:.|  |
Zfish   448 LILMMGLFSIYTGAIYNECFSKGLSPVSSGWHLKPMIQHYNWSDETLRSNQYLTLDPNITGVFQG 512

  Fly   505 VYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQIL 569
            .||||:||:|.||:|.:.||||:|||:|:|.||:||.||||:|..|:.:|...:|:||..:|:::
Zfish   513 PYPFGIDPIWSLANNHLTFLNSYKMKMSVIIGVIHMTFGVCLSFFNYMYFGNVSSVFLVLIPELV 577

  Fly   570 FLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKN--TEPPKGCNEFMFES 632
            |:|.||||:|||:.|||.      :|.|:....|||:||.||:|.||..  :.||      ::..
Zfish   578 FMLCLFGYLVFMVVFKWI------AFGPQDSDRAPSILIHFIDMFLFSENPSNPP------LYPR 630

  Fly   633 QPQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAHANHNGQ---LTG----NIELAEGETPLPT 690
            |..:|:..|.:||..:|.:||||||.:.|..:|.....|..|   :|.    |.:|.:.|
Zfish   631 QMTVQRILVCLALLAVPVLLLGKPLQLYFQHRNSRRTLHEEQRSLVTDTSSINAQLVDLE----- 690

  Fly   691 GFSGNEENAGGAHGHDDEPMSEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQM 755
                    .||.....:...:|:::.||||||||.|..||:|||||||||||||||||:||||.|
Zfish   691 --------GGGGIDEQEFEWTEVFMQQAIHTIEYCLGCISNTASYLRLWALSLAHAQLAEVLWVM 747

  Fly   756 VLSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQ 820
            |:.:.|...|..|::.|.::|..:...|::||::|||||||||.||||||||.:|||.|.||.|.
Zfish   748 VMRISLSWQGYVGSVVLSVVFSLFATLTVSILLVMEGLSAFLHALRLHWVEFQNKFYRGSGYKFN 812

  Fly   821 PFSFKAI 827
            ||||::|
Zfish   813 PFSFESI 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	27..824	CDD:460232	364/821 (44%)
tcirg1a	XP_005160329.1	V_ATPase_I	27..816	CDD:460232	364/821 (44%)