DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-4 and VHA-A3

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_568051.1	Gene:	VHA-A3 / 830063	AraportID:	AT4G39080	Length:	821	Species:	Arabidopsis thaliana

Alignment Length:	875	Identity:	325/875 - (37%)
Similarity:	491/875 - (56%)	Gaps:	115/875 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRYV 80
            :.|||.|.|||:.:..|:|:.|::.||::|.|||:|||::.:..||.:..:::||.|:.|:||:.
plant    16 LMRSETMQLVQLIVPMESAHLTVSYLGDLGLVQFKDLNSEKSPFQRTYAAQIKRCGEMARKIRFF 80

  Fly    81 TAELNKEGHKVLDLMDDFPPAPQPR------EIIDLELHLEKTETEILELAANNVNLQTSYLELS 139
            ..:::|.|          .||.:.:      ::.|:|:.|.:.|.|::|:.|||..||.||.||.
plant    81 RDQMSKAG----------VPAKEMQGKENDIDLDDVEVKLGELEAELVEINANNDKLQRSYNELM 135

  Fly   140 EMIQVLERTDQFFSD---------------------------QESHNFDLNKMGTHRDPEKSNGH 177
            |...||::..:|||.                           ||..:.|..|          ...
plant   136 EYKLVLQKAGEFFSSAHRSAADQQRETESQQAGEDLLESPLLQEEKSIDSTK----------QVK 190

  Fly   178 LGFVAGVISREREYAFERMLWRISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQAR 242
            |||:.|::.||:...|||:|:|.:|||:|:|:..::..:.||.:|....|:|||||:.|::.:::
plant   191 LGFLTGLVPREKSMVFERILFRATRGNIFIRQTVIEEPVIDPNSGEKAEKNVFVVFYSGERAKSK 255

  Fly   243 IRKVCTGFHAHMYPCPSSHSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMV 307
            |.|:|..|.|:.||.......:.:|:..|..||.:|:..|:.....|..:||....:...|:..|
plant   256 ILKICEAFGANRYPFSEDLGRQAQMITEVSGRLSELKTTIDAGLGQRNILLQTIGDKFELWNLKV 320

  Fly   308 KKMKGIYHTLNLFNVDLGSKCLIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPP 372
            :|.|.||||||:.::|:..|||:.|||.|......::.||...:....|.|.|...||.||:.||
plant   321 RKEKAIYHTLNMLSLDVTKKCLVAEGWSPVFASREIQDALQRAAVDSNSQVGSIFQVLRTKESPP 385

  Fly   373 THFRTNKFTRGFQNLIDAYGIAGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDE 437
            |:|||||||...|.::||||:|.|:|.|||::|.:||||||||||||.|||..:.|..:::::.|
plant   386 TYFRTNKFTSAIQEIVDAYGVAKYQEANPGVFTIVTFPFLFAVMFGDWGHGICILLATMYLILKE 450

  Fly   438 KRLSKKRGGEIWNIFFAGRYIIMLMGLFAMYTGFHYNDIFSKSINVFG-----TRWVNVYNRTTV 497
            |:|:.::.|:|..:.|.|||:|::|.||::|||..||:.||....:|.     .|.|:....||:
plant   451 KKLASQKLGDIMEMAFGGRYVILMMSLFSIYTGLIYNEFFSIPFPLFAPSAYDCRDVSCSEATTI 515

  Fly   498 LTNPTLQLNPSVATRGVYPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVF 562
                     ..:..|..||.|:||:|..:.:::.|||:.|||:||:.||..|..|:.||..|..|
plant   516 ---------GLIKVRDTYPFGLDPVWHGSRSELPFLNSLKMKMSILLGVSQMNLGIIMSYFNARF 571

  Fly   563 FKKYAYIILQFVPQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKT 627
            ||....|..||:||::||..:|||:..::..||     .|..:||         :..:.:.:|.:
plant   572 FKSSVNIWFQFIPQMIFLNSLFGYLSVLIIIKW-----CTGSQAD---------LYHVMIYMFLS 622

  Fly   628 ETALPGCDVNMFPIQKNLEMIFLVVALLCIPWILLGKPLYIKYQRRNRPAG----PVEEVDEIVE 688
            .....| :..:||.||.|:::.|.:||:.:|.:||.||..:|.|...|..|    |::|.||.:.
plant   623 PMDELG-ENQLFPHQKTLQLVLLFLALVSVPCMLLPKPFILKKQHEARHQGQAYAPLDETDESLH 686

  Fly   689 KIEVTTGKEIIITEVAEAHESGGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSL 753
                           .|.:..|.|..|:.| .|||::||.|||||::|..:|:||||||||||||
plant   687 ---------------VETNGGGSHGHEEFE-FSEIFVHQLIHTIEFVLGAVSNTASYLRLWALSL 735

  Fly   754 AHAQLSEVLWTMVLAMGLQMNG----YVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHW 814
            ||::||.|.:..||.:....|.    .||.  |.||||     |:.::::||.||||||.|||||
plant   736 AHSELSSVFYEKVLLLAWGYNNPLILIVGV--LVFIFA-----TVGVLLVMETLSAFLHALRLHW 793

  Fly   815 VEFMSKFYVGNGYPFTPFSFKDILIVVEDD 844
            |||.:|||.|:||.|.||:|  |....||:
plant   794 VEFQNKFYEGDGYKFAPFTF--IFTANEDE 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	322/864 (37%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	311/839 (37%)
VHA-A3	NP_568051.1	NtpI	17..814	CDD:224188	322/865 (37%)
VHA-A3	NP_568051.1	V_ATPase_I	40..813	CDD:279793	311/839 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	601	1.000	Domainoid score	I37
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	618	1.000	Inparanoid score	I211
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D181796at2759
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		mtm1001
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840