DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-4 and VHA-A1

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_850122.1	Gene:	VHA-A1 / 817400	AraportID:	AT2G28520	Length:	817	Species:	Arabidopsis thaliana

Alignment Length:	855	Identity:	317/855 - (37%)
Similarity:	490/855 - (57%)	Gaps:	89/855 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRYV 80
            :.|||.|:|||:.:..|:|:.:|..|||:|.:|||||||..:..||.|..:|:||.|:.|::|:.
plant    13 LMRSEKMTLVQLIIPVESAHRSITYLGELGLLQFRDLNADKSPFQRTFANQVKRCGEMSRKLRFF 77

  Fly    81 TAELNKEGHKV---LDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMI 142
            ..:::|.|.:.   |::..|.       .:.|||..|...|.|:||:.:|:..|:.:|.||.|..
plant    78 KDQIDKAGLRCSPRLEIEPDI-------ALGDLERQLADHEHEVLEMNSNSEKLRQTYNELLEFK 135

  Fly   143 QVLERTDQFFSDQESH--------------NFDLNKMGTHRDPEKSNGH-----LGFVAGVISRE 188
            .|||:...|.....:|              |....:..:..:.|.:.||     |.|::|:|:::
plant   136 IVLEKASGFLVSSNTHAIGEEIELHESTYSNNGFIETASLLEQEMNPGHSNQSGLRFISGIINKD 200

  Fly   189 REYAFERMLWRISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAH 253
            :...|||||:|.:|||:...:...|..:.||.|..::.|.||||||.|:|.:.:|.|:|..|.|:
plant   201 KLLKFERMLFRATRGNMLFNQTTSDEEIMDPSTSEMVEKVVFVVFFSGEQARTKILKICEAFGAN 265

  Fly   254 MYPCPSSHSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLN 318
            .||.|...::::::.:.|.:||.||:..::..:.||...|.:....|..|...|::.|.:|.|||
plant   266 CYPVPEDTTKQRQLTREVLSRLSDLEATLDAGTRHRNNALNSVGYSLTNWITTVRREKAVYDTLN 330

  Fly   319 LFNVDLGSKCLIGEGWVP---KREL-ELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNK 379
            :.|.|:..|||:||||.|   |.:: |:::.|....|:.||    ...:|:...:.|||:|||||
plant   331 MLNFDVTKKCLVGEGWCPTFAKTQIHEVLQRATFDSSSQVG----VIFHVMQAVESPPTYFRTNK 391

  Fly   380 FTRGFQNLIDAYGIAGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKRLSKKR 444
            .|..||.:|||||:|.|:|.||.:|:.:|:||||||||||.|||..|.|..|:::..|::||.::
plant   392 LTNAFQEIIDAYGVARYQEANPAVYSVVTYPFLFAVMFGDWGHGLCLLLGALYLLARERKLSTQK 456

  Fly   445 GGEIWNIFFAGRYIIMLMGLFAMYTGFHYNDIFSKSINVFGTRWVNVYN-RTTVLTNP-TLQLNP 507
            .|....:.|.|||:|:||.||::|.|..||:.||...::||.   :.|. |.|..::. |:.|
plant   457 LGSFMEMLFGGRYVILLMALFSIYCGLIYNEFFSVPFHIFGG---SAYKCRDTTCSDAYTVGL-- 516

  Fly   508 SVATRGVYPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQ 572
             :..|..||.|:||.|:.:..::.:||:.|||:||:.|:..|..|:.:|..|..||.....|..|
plant   517 -IKYRDPYPFGVDPSWRGSRTELPYLNSLKMKMSILLGIAQMNLGLILSFFNARFFGSSLDIRYQ 580

  Fly   573 FVPQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDVN 637
            |:||::||..:|||:..::..||     .|..:||         :..:.:.:|.:.|...| :..
plant   581 FIPQMIFLNSLFGYLSLLIIIKW-----CTGSQAD---------LYHVMIYMFLSPTEELG-ENE 630

  Fly   638 MFPIQKNLEMIFLVVALLCIPWILLGKPLYI------KYQRRNRPAGPVEEVDEIVEKIEVTTGK 696
            :|..|:.|:::.|::|.:.:||:|..||..:      ::|.|........|||..||
plant   631 LFWGQRPLQIVLLLLAFIAVPWMLFPKPFALRKIHMERFQGRTYGVLVSSEVDLDVE-------- 687

  Fly   697 EIIITEVAEAHESGGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEV 761
                   .::...|||.||:.. .|||::||.||:||::|.::|:||||||||||||||::||.|
plant   688 -------PDSARGGGHHEEEFN-FSEIFVHQLIHSIEFVLGSVSNTASYLRLWALSLAHSELSTV 744

  Fly   762 LW--TMVLAMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVG 824
            .:  .::||.|.: |..:..||:    ||:.|.|..|::|||.||||||.|||||||||.||:.|
plant   745 FYEKVLLLAWGYE-NILIRLIGV----AVFAFATAFILLMMETLSAFLHALRLHWVEFMGKFFNG 804

  Fly   825 NGYPFTPFSF 834
            :||.|.||||
plant   805 DGYKFKPFSF 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	317/854 (37%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	305/829 (37%)
VHA-A1	NP_850122.1	NtpI	14..814	CDD:224188	315/852 (37%)
VHA-A1	NP_850122.1	V_ATPase_I	37..814	CDD:279793	305/829 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	601	1.000	Domainoid score	I37
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	618	1.000	Inparanoid score	I211
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D181796at2759
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		mtm1001
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840