DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-4 and VHA-A2

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_179736.1	Gene:	VHA-A2 / 816680	AraportID:	AT2G21410	Length:	821	Species:	Arabidopsis thaliana

Alignment Length:	861	Identity:	336/861 - (39%)
Similarity:	504/861 - (58%)	Gaps:	88/861 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRYV 80
            :.|||.|.|||:.:..|:|:.|::.||::|.|||:|||::.:..||.:..:::||.|:.|:||:.
plant    17 LMRSEPMQLVQVIVPMESAHLTVSYLGDLGLVQFKDLNSEKSPFQRTYAAQIKRCGEMARKIRFF 81

  Fly    81 TAELNKEG---HKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMI 142
            ..:::|.|   .:.||..:|.       ::.|:|:.||:.|.|::|:.|||..||.||.||.|..
plant    82 KEQMSKAGVTPKETLDRENDI-------DLDDVEVKLEELEAELVEINANNDKLQRSYNELVEYK 139

  Fly   143 QVLERTDQFF-SDQESHNFDLNKMGTHR-----------------DPEKSNGHLGFVAGVISRER 189
            .|||:..:|| |...|.....:::.|.:                 ||.| ...|||:.|::.||:
plant   140 LVLEKAGEFFASAHRSATAQQSEIETEQVGEDLLEAPLLQEEKSVDPTK-QVKLGFLTGLVPREK 203

  Fly   190 EYAFERMLWRISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHM 254
            ...|||:|:|.:|||:|:|:..::.::.||.:|....|:|||||:.|::.:::|.|:|..|.|:.
plant   204 SMVFERILFRATRGNIFIRQSVIEESVVDPNSGEKAEKNVFVVFYSGERAKSKILKICEAFGANR 268

  Fly   255 YPCPSSHSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNL 319
            ||......::.:|:..|..||.:|:..|....|.|..:|:....:...|:..::|.|.||||||:
plant   269 YPFSEDLGKQAQMMTEVSGRLSELKTTIGAGLDQRNILLETIGDKFEQWNLKIRKEKAIYHTLNM 333

  Fly   320 FNVDLGSKCLIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGF 384
            .::|:..|||:||||.|......::.||...:....|.|.|...||.||:.|||.|||||||..|
plant   334 LSLDVTKKCLVGEGWSPVFAATEIQDALHRAAVDSNSQVGSIFQVLRTKEMPPTFFRTNKFTTAF 398

  Fly   385 QNLIDAYGIAGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKRLSKKRGGEIW 449
            |.::||||:|.|:|.||.::|.:||||||||||||.|||..|.|..:::::.||:||.::.|:|.
plant   399 QEIVDAYGVAKYQEANPSVFTIVTFPFLFAVMFGDWGHGICLLLATMYLILREKKLSSQKLGDIM 463

  Fly   450 NIFFAGRYIIMLMGLFAMYTGFHYNDIFSKSINVFGT-----RWVNVYNRTTVLTNPTLQLNPSV 509
            .:.|.|||:|.:|.||::|||..||:.||....:|.:     |.|:....||:         ..:
plant   464 EMAFGGRYVIFMMSLFSIYTGLIYNEFFSIPYPLFASSAYDCRDVSCSEATTI---------GLI 519

  Fly   510 ATRGVYPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFV 574
            .||..||.|:||:|....:::.|||:.|||:||:.||..|..|:.||..|..|||....|..|||
plant   520 KTRDTYPFGVDPVWHGTRSELPFLNSLKMKMSILIGVAQMNLGIIMSFFNAKFFKSAVNIWFQFV 584

  Fly   575 PQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDV--- 636
            ||::||..:|||:..::..||     .|..:||   ....::.||:.          |..|:
plant   585 PQMIFLNCLFGYLSVLIIIKW-----CTGSQAD---LYHVMIYMFLS----------PMDDLGEN 631

  Fly   637 NMFPIQKNLEMIFLVVALLCIPWILLGKPLYIKYQRRNRPAG-PVEEVDEIVEKIEVTTGKEIII 700
            .:||.||.:::.||.:||:.:||:||.||..:|.|...|..| ...::||..|.::|.|
plant   632 QLFPNQKIVQLTFLFLALVSVPWMLLPKPFILKKQHEARHQGLSYAQLDETDESLQVET------ 690

  Fly   701 TEVAEAHESGGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLWTM 765
                   ..|||..|:.| .|||::||.|||||::|..:|:||||||||||||||::||.|.:..
plant   691 -------NGGGHGHEEFE-FSEIFVHQLIHTIEFVLGAVSNTASYLRLWALSLAHSELSSVFYEK 747

  Fly   766 VLAMGLQMNG-YVGAIG-LFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNGYP 828
            ||.|....|. ::..:| |.||||     |:.::::||.||||||.|||||||:.:|||.|:||.
plant   748 VLLMAWGFNNVFIWIVGILVFIFA-----TVGVLLVMETLSAFLHALRLHWVEYQNKFYEGDGYK 807

  Fly   829 FTPFSFKDILIVVEDD 844
            |.||:|  .|:..||:
plant   808 FAPFTF--TLVGNEDE 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	333/850 (39%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	322/825 (39%)
VHA-A2	NP_179736.1	V_ATPase_I	40..813	CDD:396194	322/826 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	601	1.000	Domainoid score	I37
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	618	1.000	Inparanoid score	I211
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D181796at2759
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		mtm1001
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840