DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-4 and atp6v0a2a

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	XP_009303407.1	Gene:	atp6v0a2a / 561469	ZFINID:	ZDB-GENE-091113-4	Length:	848	Species:	Danio rerio

Alignment Length:	857	Identity:	375/857 - (43%)
Similarity:	538/857 - (62%)	Gaps:	45/857 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRYVT 81
            ||||.|.|.|::||..:||..|:.|||:|.|:|||||..:::.||:|:.|::||:|:||.:.|:.
Zfish     5 FRSEEMCLAQLFLQSGSAYACISELGEMGLVEFRDLNPSVSSFQRRFVSEIKRCEEMERILGYLL 69

  Fly    82 AELNKEGHKVLDLMDDFPP-APQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQVL 145
            .|:.|....|.:.  :.|| ||.|:.::::...|::.|.|:.|:|.|...||.:.|||.|...:|
Zfish    70 REIRKANIAVPEA--EVPPVAPAPKNVLEIMEQLQRLEVELSEVAKNKEKLQRNLLELMEYTHML 132

  Fly   146 ERTDQFFSDQESH-----------NFDLNKMGTHRDPEKSNGHLGFVAGVISREREYAFERMLWR 199
            ..|..|...:..|           :.:...:......::....||||:|:|.|.:..||||||||
Zfish   133 RITRSFVHSRSRHEALGPQYEEFPSLETESVTGCTSMQRLGAKLGFVSGLIQRVKVEAFERMLWR 197

  Fly   200 ISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSSHSER 264
            :.:|...:...:||.:|.|..||.:....||::.|.|||:..:::|:|..:|.|:||.|.:..||
Zfish   198 VCKGYTILSYAEVDESLADLDTGEIRKNVVFLISFWGDQIGQKVQKICDCYHCHIYPHPETDEER 262

  Fly   265 QEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLGSKCL 329
            .:::.::|||::||..::::|.|:...||..|.:...:|...|||||.|||.|||.:.|:.:|||
Zfish   263 ADVMDSLRTRIQDLHNVLHRTEDYLKQVLHKASESAQSWVLQVKKMKAIYHILNLCSFDVTNKCL 327

  Fly   330 IGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDAYGIA 394
            |.|.|.|..:|..:..||..||....:|||||:|.:.:...|||..|:||||.|||::::|||:.
Zfish   328 IAEVWCPVSDLANLRRALEEGSRKGDATVPSFVNRIPSSDTPPTLLRSNKFTSGFQSIVEAYGVG 392

  Fly   395 GYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKRLSKKR-GGEIWNIFFAGRYI 458
            .||||:|..:|.|||||||||||||:|||::|.|..||||:.||..:::| |.||....|.||||
Zfish   393 DYREVSPAPFTIITFPFLFAVMFGDLGHGSVLTLFALWMVLTEKDHTRRRPGNEIRMTLFDGRYI 457

  Fly   459 IMLMGLFAMYTGFHYNDIFSKSINVFGTRW-------VNVYNRTTVLTNPTLQLNPSVA--TRGV 514
            |::||||::|||..|||.||||:|:||:.|       ...:...|:.:|..|.|||:|:  ..|.
Zfish   458 ILMMGLFSIYTGLIYNDCFSKSLNIFGSAWSVKAMFTEQEWTNETLRSNMLLTLNPNVSGVFSGP 522

  Fly   515 YPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFVPQVLF 579
            ||:||||||..|.|::.|||:||||:|:|.||:||.|||.:||.|.:.|::...|.|.|:|::||
Zfish   523 YPLGIDPIWNMAVNRLTFLNSYKMKMSVIIGVVHMSFGVVLSVFNHLHFRQKYKIYLLFLPELLF 587

  Fly   580 LLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDVNMFPIQKN 644
            ||.:|||:.||:||||:.|:      |.....|||:||.||:|.|.:.....|     ::|.|..
Zfish   588 LLCLFGYLAFMIFYKWLAYT------ARDSQLAPSILIHFINMFLMQANATSP-----LYPGQMG 641

  Fly   645 LEMIFLVVALLCIPWILLGKPLYIKYQRRNRPAGPVEEV------DEIVEKI-EVTTGKEIIITE 702
            |::..:|||||.:|.:|||||||:.:......:..:..|      .|.|.:: |......::..|
Zfish   642 LQVFLVVVALLSVPVLLLGKPLYLYWLHHGGKSLGIHRVCLCSCGYERVRRVSEEDLSPSVVHDE 706

  Fly   703 VAEAHESGGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLWTMVL 767
            .....||||..|.|   ..::::|||||||||.|..||:||||||||||||||||||||||.||:
Zfish   707 EEGLSESGGPQEFD---FGDVFLHQAIHTIEYSLGCISNTASYLRLWALSLAHAQLSEVLWAMVM 768

  Fly   768 AMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNGYPFTPF 832
            .:||:::..:|.|.|..:|:|:...||:|:::|||||||||.||||||||.:|||.|.|..|.||
Zfish   769 RLGLRISSRLGVIFLVPVFSVFAVLTISILLVMEGLSAFLHALRLHWVEFQNKFYSGAGVKFAPF 833

  Fly   833 SFKDILIVVEDD 844
            .|..:..|.|.|
Zfish   834 DFSLLPSVFEQD 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	372/847 (44%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	359/822 (44%)
atp6v0a2a	XP_009303407.1	NtpI	26..833	CDD:224188	358/822 (44%)
atp6v0a2a	XP_009303407.1	V_ATPase_I	28..835	CDD:279793	359/822 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.830