Protein Alignment Vha100-4 and atp6v0a2b

DIOPT Version :10

• Sequence 1: NP_650720.1
• Gene: Vha100-4 / 42214
• FlyBaseID: FBgn0038613
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001116219.1
• Gene: atp6v0a2b / 561117
• ZFINID: ZDB-GENE-060526-4
• Length: 849
• Species: Danio rerio
• Alignment Length: 857
• Identity: 370/857 - (43%)
• Similarity: 544/857 - (63%)
• Gaps: 60/857 - (7%)

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |:||||.|.|.|::||..:|||.|:.|||:|.|:|||||..:|:.||||:.|::||:|:||.:.|
Zfish     3 SLFRSEEMCLAQLFLQSGSAYDCISELGELGLVEFRDLNPSVNSFQRKFVNEIKRCEEMERILGY 67

  Fly    80 VTAELNKEGHKVLDLM----DDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSE 140
            :..|:.||     |:.    :..|.||.|:.::.:...|::.|.|:.|:..|...||.:.|||:|
Zfish    68 LLREIKKE-----DIPLPEGEVNPAAPLPKHVMVIMEQLQRLELELGEVTRNKEKLQKNLLELTE 127

  Fly   141 MIQVLERTDQFF---SDQESHN--------FDLNKMGTHRDPEKSNGHLGFVAGVISREREYAFE 194
            ...:|..|..|.   :::||..        .:...|..:...::....|||::|:|...:..|||
Zfish   128 YTHMLRITRNFVHRGTERESTQGQYEEFPFLEKEPMMDYTSMQRLGAKLGFISGLIQSVKIEAFE 192

  Fly   195 RMLWRISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPS 259
            |||||:.:|...:...:||..|.||.:|......||::.:.|:|:..:::|:|..:|.|:||.|:
Zfish   193 RMLWRVCKGYTILSYSEVDELLDDPDSGEPTRSVVFLISYWGEQIGQKVKKICDCYHCHLYPYPN 257

  Fly   260 SHSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDL 324
            |:.||.::|:.:|||::||..::::|.|:...||..|.:.:..|...|||||.|||.|||.:.|:
Zfish   258 SNEERTDVVEGLRTRIQDLHTVLHRTEDYLRQVLIKASESVYIWVIQVKKMKAIYHILNLCSFDV 322

  Fly   325 GSKCLIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLID 389
            .:||||.|.|.|..:|..:..||..||...|:|||||:|.:.:...|||..||||||.||||::|
Zfish   323 TNKCLIAEVWCPVNDLPALRRALEDGSRKSGATVPSFVNRIPSSDTPPTLIRTNKFTSGFQNIVD 387

  Fly   390 AYGIAGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEK-RLSKKRGGEIWNIFF 453
            |||::.||||||..||.|||||||||||||:|||.|:.|..||||:.|. |..||...|||||||
Zfish   388 AYGVSSYREVNPAPYTIITFPFLFAVMFGDLGHGIIMALFALWMVLYENDRKLKKTRNEIWNIFF 452

  Fly   454 AGRYIIMLMGLFAMYTGFHYNDIFSKSINVFGTRWVNV--------YNRTTVLTNPTLQLNPSV- 509
            .|||||:|||:|::|||..|||.||||:|:||:.| ||        :..:||.:|..|.|:|::
Zfish   453 EGRYIILLMGVFSVYTGLIYNDCFSKSLNIFGSGW-NVSAMFENGDWTLSTVNSNKLLALDPNIT 516

  Fly   510 -ATRGVYPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQF 573
             ..:|.||:||||||..|||::.|||:||||:|:|.|::||.|||.:.:.|.:.|::...:.|.|
Zfish   517 GVFKGPYPLGIDPIWNLASNRLTFLNSYKMKMSVIVGIIHMTFGVVLGIFNHLHFRRTINVYLIF 581

  Fly   574 VPQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDVNM 638
            :|::||||.:|||:.||:.|||:.:   |..::.|   |||:||.||:|.|...::..|     :
Zfish   582 LPELLFLLCLFGYLVFMIIYKWLFF---TVRDSQT---APSILIHFINMFLMMGDSGRP-----L 635

  Fly   639 FPIQKNLEMIFLVVALLCIPWILLGKPLYIKYQRRNRPAGPV-----------EEVDEIVEKIEV 692
            :|.|...::..::||:..:|.:|.||||||.:|.:.|....:           ||...::...::
Zfish   636 YPGQAGFQVFLVIVAVFSVPVLLFGKPLYIYWQHKGRDRLSMYRGYQRVRRSSEEELSLLHTHDL 700

  Fly   693 TTGKEIIITEVAEAHESGGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQ 757
            ..|..:      ::|.|...|:.::....:::::|:||||||.|..||:||||||||||||||||
Zfish   701 EEGSSL------DSHSSSSDSQSEEPDFPDLFLNQSIHTIEYCLGCISNTASYLRLWALSLAHAQ 759

  Fly   758 LSEVLWTMVLAMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFY 822
            ||||||.||:.:.|.::..||.:.|..:|.::...|::|:::|||||||||.||||||||.:|||
Zfish   760 LSEVLWEMVMRVALHVDTSVGIVLLVPVFGLFAVLTVSILLVMEGLSAFLHALRLHWVEFQNKFY 824

  Fly   823 VGNGYPFTPFSF 834
            .|.|..|.||:|
Zfish   825 SGVGVKFIPFAF 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	V_ATPase_I	39..834	CDD:460232	355/831 (43%)
atp6v0a2b	NP_001116219.1	V_ATPase_I	27..836	CDD:460232	355/831 (43%)