DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-4 and atp6v0a1b

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	XP_009295518.1	Gene:	atp6v0a1b / 553691	ZFINID:	ZDB-GENE-050522-215	Length:	868	Species:	Danio rerio

Alignment Length:	882	Identity:	418/882 - (47%)
Similarity:	572/882 - (64%)	Gaps:	82/882 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRYV 80
            :||||.|:|.|::||.||||..::.|||:|.|||||||..:|..||||:.|||||:|::|::|:|
Zfish     4 LFRSEEMTLAQLFLQSEAAYCCVSELGELGMVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFV 68

  Fly    81 TAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQVL 145
            ..|:.|.....:|..:: |..|.||::||||...||.|.|:.|:..|...|:.::|||:|:..:|
Zfish    69 EKEIKKANIPTMDTGEN-PEVPFPRDMIDLEATFEKLENELKEINTNQEALKKNFLELTELKHIL 132

  Fly   146 ERTDQFFSDQESHNFDLNKMGTHRDP-EKSNG---HLGFVAGVISREREYAFERMLWRISRGNVF 206
            .||.|||.:.|..|. |.:..:..|| |...|   .||||||||:|||...|||||||:.|||||
Zfish   133 RRTQQFFDEMEDPNL-LEESSSLLDPSEAGRGAPLRLGFVAGVINRERIPTFERMLWRVCRGNVF 196

  Fly   207 VRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSSHSERQEMVKNV 271
            :|:.:::..|.||.||:.:|||||::|||||||:.|::|:|.||.|.:||||.:..||:||...|
Zfish   197 LRQTEIEDPLEDPTTGDQVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGV 261

  Fly   272 RTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLGSKCLIGEGWVP 336
            .||::|||:::|||.|||..|||||.|.:..|...|:|||.|||||||.|:|:..||||.|.|.|
Zfish   262 NTRIDDLQMVLNQTEDHRQRVLQAAAKTMRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCP 326

  Fly   337 KRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDAYGIAGYREVNP 401
            ..:|:.::.||..|:...||||||.:|.:.||:.|||:.:|||||.||||::|||||..|||:||
Zfish   327 VSDLDSIQFALRRGTERSGSTVPSILNRMQTKQTPPTYNKTNKFTSGFQNIVDAYGIGTYREINP 391

  Fly   402 GLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKR-LSKKRGGEIWNIFFAGRYIIMLMGLF 465
            ..||.|||||||||||||||||.::....|::|:.|.| |::|...|::|:.|||||||:|||:|
Zfish   392 APYTIITFPFLFAVMFGDMGHGVLMTSAALYLVLRETRLLAQKSDNEMFNMIFAGRYIILLMGMF 456

  Fly   466 AMYTGFHYNDIFSKSINVFGTRWV--------NVYNRTTVLTNPTLQLNPSVA--TRGVYPMGID 520
            ::|||..|||.||||:|:|.:.|.        ..:...|:.:|..|||||||:  ..|.||:|||
Zfish   457 SVYTGLIYNDCFSKSLNMFSSGWSVRPMFAPNGNWTDQTLESNSVLQLNPSVSGVFGGPYPLGID 521

  Fly   521 PIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFVPQVLFLLLMFG 585
            |||..|:||:.|||::|||:|:|.||:||:|||.:|:.|.::|||...|.|.|:|:::|:..:||
Zfish   522 PIWNIAANKLTFLNSFKMKMSVILGVIHMLFGVTLSLFNHLYFKKPLNIFLNFIPEIVFMSSLFG 586

  Fly   586 YMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLF--KTETALPGCDVNMFPIQKNLEMI 648
            |:..::||||:.|...|..:      |||:||.||:|.||  ...|..|     ::..|..::.:
Zfish   587 YLILLIFYKWIAYDAVTSKD------APSLLIAFINMCLFNYNDPTNKP-----LYRGQAGIQSL 640

  Fly   649 FLVVALLCIPWILLGKPLYIKYQ----------RRNRPA-------------------------- 677
            .:|:||.|:|.:|:.|.:.::.|          |..|||
Zfish   641 LVVIALACVPVMLVVKTMILRRQHLWKKHLSQMRDARPAENLETLEQTGTSSPPGLTQQGTQKFG 705

  Fly   678 ------GPVEEVDEIVEKIEVTTGKEIIITEVAEAHESGGHSEEDDEPMSEIWIHQAIHTIEYIL 736
                  ||.|:..||::..:::...|          |...||||:.....::.:|||||||||.|
Zfish   706 GVRVGNGPTEDEAEIIDHDQLSQHSE----------EGDEHSEEEPFNFGDMAVHQAIHTIEYCL 760

  Fly   737 STISHTASYLRLWALSLAHAQLSEVLWTMVLAMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMME 801
            ..||:||||||||||||||||||||||.||:.:||......|..||..||:.:...|:.|:::||
Zfish   761 GCISNTASYLRLWALSLAHAQLSEVLWGMVMRLGLSSRSGGGFFGLSIIFSAFATLTVCILLIME 825

  Fly   802 GLSAFLHTLRLHWVEFMSKFYVGNGYPFTPFSFKDIL 838
            |||||||.||||||||.:|||.|.|:.|.||||:.||
Zfish   826 GLSAFLHALRLHWVEFQNKFYTGQGFKFVPFSFESIL 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	416/877 (47%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	401/852 (47%)
atp6v0a1b	XP_009295518.1	NtpI	27..860	CDD:224188	403/855 (47%)
atp6v0a1b	XP_009295518.1	V_ATPase_I	28..858	CDD:279793	401/852 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582319
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.720