DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-4 and atp6v0a2

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001016223.1	Gene:	atp6v0a2 / 548977	XenbaseID:	XB-GENE-960957	Length:	845	Species:	Xenopus tropicalis

Alignment Length:	856	Identity:	375/856 - (43%)
Similarity:	532/856 - (62%)	Gaps:	50/856 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |.||||.|.|.|::||..:|||.::.|||:|..:|||||.:::|.||||:|||::|:|:||.:.|
Frog     3 SFFRSEAMCLAQLFLQSGSAYDCVSELGEMGLAEFRDLNPQVSAFQRKFVGEVKKCEEMERILGY 67

  Fly    80 VTAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQV 144
            :..|:.|....|.: ....|.||.|:.::|::..|:|.|.|:.|:..|...||.:.||:.|...:
Frog    68 LMQEIQKANIPVPE-ESLTPEAPLPKHVLDIQEQLQKLEVELREVNKNKEKLQKNLLEMIEYTYM 131

  Fly   145 LERTDQFFSDQESHNFDLNKMGTHRD--------------PEKSNGHLGFVAGVISREREYAFER 195
            |..|:........|  :.:...|:.:              .::....||||:|::.|.:..:||:
Frog   132 LRVTNYLVHRSNEH--ETSAHSTYEEFPALEKESLIDYTCMQRLGAKLGFVSGLVHRAKLESFEK 194

  Fly   196 MLWRISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSS 260
            ||||:.:|...:...::|..|..|.|.......||||.:.|||:..:::|:|..:..|:||..:|
Frog   195 MLWRVCKGYTVLTYQELDEYLLHPDTEEPTRWFVFVVSYWGDQIGQKVKKICECYDCHLYPYTNS 259

  Fly   261 HSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLG 325
            ..||:.::..:.||::||..:|:||.|:...||..|.:.:..|...:||||.|||.||....|:.
Frog   260 AEERRNLLSELNTRIQDLHKVISQTDDYLKQVLFKASESVYKWVIQIKKMKAIYHVLNFCRFDVT 324

  Fly   326 SKCLIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDA 390
            :||||.|.|.|..:|..|..||..||...|.:||||||.:.:...|||..||||||.||||::||
Frog   325 NKCLIAEVWCPVADLPNVRRALEEGSRKSGVSVPSFINRIPSNDTPPTLIRTNKFTSGFQNIVDA 389

  Fly   391 YGIAGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEK--RLSKKRGGEIWNIFF 453
            ||:..|||:||..||.|||||||||||||.|||.::.|..|.||:.||  :|::.: .||...||
Frog   390 YGVGNYREMNPAPYTIITFPFLFAVMFGDFGHGILMSLFALCMVVFEKSPKLARSQ-DEIMKTFF 453

  Fly   454 AGRYIIMLMGLFAMYTGFHYNDIFSKSINVFGTRW-------VNVYNRTTVLTNPTLQLNPSV-- 509
            .|||||:|||||::|||..|||.||||:|:||:.|       .||: ||..|:|..|.|||:|
Frog   454 EGRYIILLMGLFSIYTGLIYNDCFSKSMNIFGSSWNVSAMFSSNVW-RTQDLSNKFLTLNPNVTG 517

  Fly   510 ATRGVYPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFV 574
            ...||||:||||||..::|::.|||::|||:|:|.||:||.|||.:|..|::.|||...|.|.|:
Frog   518 VLTGVYPVGIDPIWSLSTNRLSFLNSFKMKMSVILGVIHMTFGVVLSAFNYMHFKKRFCIFLVFI 582

  Fly   575 PQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDVNMF 639
            |::||::.:|||:.||:.|||:.||     .||:.. |||:|:.||:|.:|.....:|.    :|
Frog   583 PELLFMICIFGYLVFMILYKWLAYS-----AADSRN-APSILLHFINMFMFSKNDQIPA----LF 637

  Fly   640 PIQKNLEMIFLVVALLCIPWILLGKPLYIKYQR------RNRPAG--PVEEVDEIVEKIEVTTGK 696
            ..|..:::..:|:..||:|.:|.|||||:.:|.      ||...|  .|....|  |:|.:....
Frog   638 TGQVGIQIFLIVLVTLCVPVLLFGKPLYLYWQHHGGQTLRNYRKGYTLVRRGSE--EEISLVRSH 700

  Fly   697 EIIITEVAEAHESGGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEV 761
            ::...|:..:||.....:::....:::::.||||||||.|..||:||.|||||||||||||||||
Frog   701 DLEEGEINSSHEVQRDRDKEKFDFADVFMSQAIHTIEYCLGCISNTALYLRLWALSLAHAQLSEV 765

  Fly   762 LWTMVLAMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNG 826
            ||.|::..||.:...||...|..:|||:.|.||||:::|||||||||.||||||||.:|||.|.|
Frog   766 LWGMIMRKGLNVEPSVGVFVLIPLFAVFAFLTIAILLVMEGLSAFLHALRLHWVEFQNKFYTGAG 830

  Fly   827 YPFTPFSFKDI 837
            |.|.|||||.|
Frog   831 YKFNPFSFKHI 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	372/851 (44%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	358/826 (43%)
atp6v0a2	NP_001016223.1	NtpI	27..839	CDD:224188	359/828 (43%)
atp6v0a2	NP_001016223.1	V_ATPase_I	28..838	CDD:279793	358/826 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11629
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110