DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-4 and ATP6V0A4

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_065683.2	Gene:	ATP6V0A4 / 50617	HGNCID:	866	Length:	840	Species:	Homo sapiens

Alignment Length:	856	Identity:	402/856 - (46%)
Similarity:	562/856 - (65%)	Gaps:	56/856 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |:||||.|.|.|::||.||||..:|.|||:|.|||:|||..:|:.||||:.|||||:.|||.:|:
Human     3 SVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERILRF 67

  Fly    80 VTAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQV 144
            :..|:..|  .|:.|::..|..|.|||:|.||..|||.|.|:.|...|...|:.|:|||:|:..:
Human    68 LEDEMQNE--IVVQLLEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTELKYL 130

  Fly   145 LERT-----------DQFFSDQESHNFDLNKMGTHRDPEKSNGHLGFVAGVISREREYAFERMLW 198
            |::|           |.||::..|...:|..:     |....|.|||:||||:|||..:|||:||
Human   131 LKKTQDFFETETNLADDFFTEDTSGLLELKAV-----PAYMTGKLGFIAGVINRERMASFERLLW 190

  Fly   199 RISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSSHSE 263
            ||.||||:::..::|..|.||.|...:.|::|::|:||:||:.:|:|:|.||.|.:||||....|
Human   191 RICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPAVE 255

  Fly   264 RQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLGSKC 328
            |:||:::|..|||||..:|.||..||..:||.|.....:|...|:|||.:||.||:.|:|:..:|
Human   256 RREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQQC 320

  Fly   329 LIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDAYGI 393
            :|.|.|.|..:...::.||..|....||::...:..:.:|..|||..||||||.||||::||||:
Human   321 VIAEIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGV 385

  Fly   394 AGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKR-LSKKRGGEIWNIFFAGRY 457
            ..|||:||..||.|||||||||||||.||||::.|..|||:::|:| ||:|...||||.||.|||
Human   386 GSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFHGRY 450

  Fly   458 IIMLMGLFAMYTGFHYNDIFSKSINVFGTRWV-------NVYNRTTVLTNPTLQLNPSVATRGV- 514
            :|:|||:|::|||..|||.||||:|:||:.|.       ..:|...:..:..|||:|::.  ||
Human   451 LILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLYLQLDPAIP--GVY 513

  Fly   515 ----YPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFVP 575
                ||.||||||..||||:.|||:||||:|:|.|::.|||||.:|:.|.::|::...|||||:|
Human   514 FGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIP 578

  Fly   576 QVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDVNMFP 640
            :::|:|.:|||:.||:.:||..:    ||.....  |||:||.||:|.||....:   .:..::.
Human   579 EMIFILCLFGYLVFMIIFKWCCF----DVHVSQH--APSILIHFINMFLFNYSDS---SNAPLYK 634

  Fly   641 IQKNLEMIFLVVALLCIPWILLGKPLYIKYQRRNRPAGPVEEVDEIVEKIE-------VTTGKEI 698
            .|:.::..|:|:||:.:||:||.||..::...|..........::..|.||       ..:|:.
Human   635 HQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQEDATENIEGDSSSPSSRSGQR- 698

  Fly   699 IITEVAEAHES-GGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVL 762
               ..|:.|.: ..|.||.:  ..::::|||||||||.|..||:|||||||||||||||||||||
Human   699 ---TSADTHGALDDHGEEFN--FGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVL 758

  Fly   763 WTMVLAMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNGY 827
            ||||:..|||..|:.|.:|:|.||||:...|:||:::|||||||||.||||||||.:|||||:||
Human   759 WTMVMNSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGDGY 823

  Fly   828 PFTPFSFKDIL 838
            .|:|||||.||
Human   824 KFSPFSFKHIL 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	398/850 (47%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	382/825 (46%)
ATP6V0A4	NP_065683.2	NtpI	28..831	CDD:224188	383/826 (46%)
		V_ATPase_I	28..830	CDD:279793	382/825 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..704		5/32 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.790