Protein Alignment Vha100-4 and ATP6V0A4

DIOPT Version :10

• Sequence 1: NP_650720.1
• Gene: Vha100-4 / 42214
• FlyBaseID: FBgn0038613
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_065683.2
• Gene: ATP6V0A4 / 50617
• HGNCID: 866
• Length: 840
• Species: Homo sapiens
• Alignment Length: 856
• Identity: 402/856 - (46%)
• Similarity: 562/856 - (65%)
• Gaps: 56/856 - (6%)

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |:||||.|.|.|::||.||||..:|.|||:|.|||:|||..:|:.||||:.|||||:.|||.:|:
Human     3 SVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERILRF 67

  Fly    80 VTAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQV 144
            :..|:..|  .|:.|::..|..|.|||:|.||..|||.|.|:.|...|...|:.|:|||:|:..:
Human    68 LEDEMQNE--IVVQLLEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTELKYL 130

  Fly   145 LERT-----------DQFFSDQESHNFDLNKMGTHRDPEKSNGHLGFVAGVISREREYAFERMLW 198
            |::|           |.||::..|...:|..:     |....|.|||:||||:|||..:|||:||
Human   131 LKKTQDFFETETNLADDFFTEDTSGLLELKAV-----PAYMTGKLGFIAGVINRERMASFERLLW 190

  Fly   199 RISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSSHSE 263
            ||.||||:::..::|..|.||.|...:.|::|::|:||:||:.:|:|:|.||.|.:||||....|
Human   191 RICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPAVE 255

  Fly   264 RQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLGSKC 328
            |:||:::|..|||||..:|.||..||..:||.|.....:|...|:|||.:||.||:.|:|:..:|
Human   256 RREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQQC 320

  Fly   329 LIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDAYGI 393
            :|.|.|.|..:...::.||..|....||::...:..:.:|..|||..||||||.||||::||||:
Human   321 VIAEIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGV 385

  Fly   394 AGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKR-LSKKRGGEIWNIFFAGRY 457
            ..|||:||..||.|||||||||||||.||||::.|..|||:::|:| ||:|...||||.||.|||
Human   386 GSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFHGRY 450

  Fly   458 IIMLMGLFAMYTGFHYNDIFSKSINVFGTRWV-------NVYNRTTVLTNPTLQLNPSVATRGV- 514
            :|:|||:|::|||..|||.||||:|:||:.|.       ..:|...:..:..|||:|::.  ||
Human   451 LILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLYLQLDPAIP--GVY 513

  Fly   515 ----YPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFVP 575
                ||.||||||..||||:.|||:||||:|:|.|::.|||||.:|:.|.::|::...|||||:|
Human   514 FGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIP 578

  Fly   576 QVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDVNMFP 640
            :::|:|.:|||:.||:.:||..:    ||.....  |||:||.||:|.||....:   .:..::.
Human   579 EMIFILCLFGYLVFMIIFKWCCF----DVHVSQH--APSILIHFINMFLFNYSDS---SNAPLYK 634

  Fly   641 IQKNLEMIFLVVALLCIPWILLGKPLYIKYQRRNRPAGPVEEVDEIVEKIE-------VTTGKEI 698
            .|:.::..|:|:||:.:||:||.||..::...|..........::..|.||       ..:|:.
Human   635 HQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQEDATENIEGDSSSPSSRSGQR- 698

  Fly   699 IITEVAEAHES-GGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVL 762
               ..|:.|.: ..|.||.:  ..::::|||||||||.|..||:|||||||||||||||||||||
Human   699 ---TSADTHGALDDHGEEFN--FGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVL 758

  Fly   763 WTMVLAMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNGY 827
            ||||:..|||..|:.|.:|:|.||||:...|:||:::|||||||||.||||||||.:|||||:||
Human   759 WTMVMNSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGDGY 823

  Fly   828 PFTPFSFKDIL 838
            .|:|||||.||
Human   824 KFSPFSFKHIL 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	V_ATPase_I	39..834	CDD:460232	383/826 (46%)
ATP6V0A4	NP_065683.2	V_ATPase_I	27..830	CDD:460232	383/826 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..704		5/32 (16%)