DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vha100-4 and Atp6v0a1

DIOPT Version :9

Sequence 1:NP_650720.1 Gene:Vha100-4 / 42214 FlyBaseID:FBgn0038613 Length:844 Species:Drosophila melanogaster
Sequence 2:XP_017452683.1 Gene:Atp6v0a1 / 29757 RGDID:68405 Length:870 Species:Rattus norvegicus


Alignment Length:888 Identity:421/888 - (47%)
Similarity:582/888 - (65%) Gaps:94/888 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 IFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRYV 80
            :||||.|:|.|::||.||||..::.|||:|.|||||||..:|..||||:.|||||:|::|::|:|
  Rat     4 LFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFV 68

  Fly    81 TAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQVL 145
            ..|:.|....::|..:: |..|.||::||||.:.||.|.|:.|:..|...|:.::|||:|:..:|
  Rat    69 EKEIRKANIPIMDTGEN-PEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFIL 132

  Fly   146 ERTDQFFSDQESHNFD------LNKMGTHRDP-EKSNG---HLGFVAGVISREREYAFERMLWRI 200
            .:|.|||.:.|.|:..      |.:..:..:| |...|   .||||||||:|||...|||||||:
  Rat   133 RKTQQFFDEAELHHQQMADPDLLEESSSLLEPNEMGRGAPLRLGFVAGVINRERIPTFERMLWRV 197

  Fly   201 SRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSSHSERQ 265
            .|||||:|:.:::..|.||.||:.:|||||::|||||||:.|::|:|.||.|.:||||.:..||:
  Rat   198 CRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERK 262

  Fly   266 EMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLGSKCLI 330
            ||...|.||::|||:::|||.|||..|||||.|.:..|...|:|||.|||||||.|:|:..||||
  Rat   263 EMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLI 327

  Fly   331 GEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDAYGIAG 395
            .|.|.|..:|:.::.||..|:...||||||.:|.:.|.:.|||:.:|||||.||||::|||||..
  Rat   328 AEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTHGFQNIVDAYGIGT 392

  Fly   396 YREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKR-LSKKRGGEIWNIFFAGRYII 459
            |||:||..||.|||||||||||||.|||.::.|..:|||:.|.| ||:|...|::::.|:|||||
  Rat   393 YREINPAPYTVITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSMVFSGRYII 457

  Fly   460 MLMGLFAMYTGFHYNDIFSKSINVFGTRW-------VNVYNRTTVLTNPTLQLNPSV--ATRGVY 515
            :|||||::|||..|||.||||:|:||:.|       :..:...|:|.:..|||||::  ...|.|
  Rat   458 LLMGLFSIYTGLIYNDCFSKSLNIFGSSWSVRPMFTIGNWTEETLLGSSVLQLNPAIPGVFGGPY 522

  Fly   516 PMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFVPQVLFL 580
            |.||||||..|:||:.|||::|||:|:|.|::||:|||.:|:.|.::|||...|...|:|:::|:
  Rat   523 PFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFM 587

  Fly   581 LLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFK-TETALPGCDVNMFPIQKN 644
            ..:|||:..::||||..|      :|.:...|||:||.||:|.||. .|:.    :..::..||.
  Rat   588 SSLFGYLVILIFYKWTAY------DAHSSRNAPSLLIHFINMFLFSYPESG----NAMLYSGQKG 642

  Fly   645 LEMIFLVVALLCIPWILLGKPLYIKYQRRNR------------------------PA-------- 677
            ::...:|||:||:||:||.|||.:::|...:                        ||        
  Rat   643 IQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLEGQPVEAPVTPAPSQQGLEAAPAATGTLNFG 707

  Fly   678 ------GPVEEVDEIVEKIEVTTGKEIIITEVAEAHESGGHSEEDDEP-------MSEIWIHQAI 729
                  ||.||..||::..:::|                 |||:.:||       ..:..:||||
  Rat   708 GIRVGNGPTEEDAEIIQHDQLST-----------------HSEDAEEPTEDEVFDFGDTMVHQAI 755

  Fly   730 HTIEYILSTISHTASYLRLWALSLAHAQLSEVLWTMVLAMGLQMNGYVGAIGLFFIFAVWEFFTI 794
            |||||.|..||:|||||||||||||||||||||||||:.:||.:....|.:|||||||.:...|:
  Rat   756 HTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLHVRSLAGGLGLFFIFAAFATLTV 820

  Fly   795 AIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNGYPFTPFSFKDI 837
            ||:::|||||||||.||||||||.:|||.|.|:.|.||||:.|
  Rat   821 AILLIMEGLSAFLHALRLHWVEFQNKFYTGTGFKFLPFSFEHI 863

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Vha100-4NP_650720.1 NtpI 17..836 CDD:224188 420/884 (48%)
V_ATPase_I 40..834 CDD:279793 405/859 (47%)
Atp6v0a1XP_017452683.1 V_ATPase_I 27..860 CDD:396194 405/860 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342349
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1269
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53812
OrthoDB 1 1.010 - - D164762at33208
OrthoFinder 1 1.000 - - FOG0000328
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100301
Panther 1 1.100 - - O PTHR11629
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X226
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.760

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