Protein Alignment Vha100-4 and Tcirg1

DIOPT Version :10

• Sequence 1: NP_650720.1
• Gene: Vha100-4 / 42214
• FlyBaseID: FBgn0038613
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_954520.3
• Gene: Tcirg1 / 293650
• RGDID: 735136
• Length: 834
• Species: Rattus norvegicus
• Alignment Length: 857
• Identity: 337/857 - (39%)
• Similarity: 502/857 - (58%)
• Gaps: 67/857 - (7%)

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |:||||.::|||:.|...:||:.::.|||:|.|:|||||..::|.||:|:.|||||:|||:...:
  Rat     3 SMFRSEEVALVQLLLPTASAYNCVSQLGELGLVEFRDLNESVSAFQRRFVVEVRRCEELEKTFTF 67

  Fly    80 VTAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQV 144
            :..|:.:.| ..|...:...|||.||:::.::...::...|:.::..|...|:....:|.....|
  Rat    68 LREEVQRAG-LTLTPPEGTLPAPPPRDLLRIQEETDRLAQELRDVRGNQQALRAQLHQLQLHSAV 131

  Fly   145 L------------------ERTDQFFSDQESHNFDLNKMGTHRDPEKSNGHLGFVAGVISREREY 191
            |                  |||....:..          |.|.|.:     :.||||.:...:..
  Rat   132 LGQSHAPPMAAVHTEGPTTERTPLLSATP----------GPHADLK-----VNFVAGAVEPCKAA 181

  Fly   192 AFERMLWRISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYP 256
            |.||:|||..||.:.....:.:..|.||.||.......||:.:.|:|:..::||:...||.|::|
  Rat   182 ALERLLWRACRGFLIASFKETEGQLEDPVTGEPATWMTFVISYWGEQIGQKVRKITDCFHCHVFP 246

  Fly   257 CPSSHSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFN 321
            .......|...::.::.:.::||.::.:|....:.||....:.||.....::|||.:|.|||..:
  Rat   247 YLEQEEARLRTLQQLQQQSQELQEVLGETERFLSQVLGRVQQLLPPGQVQIRKMKAVYLTLNQCS 311

  Fly   322 VDLGSKCLIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQN 386
            |:...||||.|.|...|:|..|:.||.:||:..|  |.:..:.:..:..|||..|||:||..||.
  Rat   312 VNTTHKCLIAEVWCATRDLPTVQQALQSGSSEEG--VSAVAHRIPCQDMPPTLIRTNRFTSSFQG 374

  Fly   387 LIDAYGIAGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKRLS-KKRGGEIWN 450
            ::||||:..||||||..||.|||||||||||||:|||.::||..|.||:.|.:.: |....|||.
  Rat   375 IVDAYGVGRYREVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMVLTENQPAVKTTQNEIWQ 439

  Fly   451 IFFAGRYIIMLMGLFAMYTGFHYNDIFSKSINVFGTRW-------VNVYNRTTVLTNPTLQLNPS 508
            .||.|||:::|||||::||||.||:.||::..:|.:.|       .:.::...:..:|.|.|||:
  Rat   440 TFFGGRYLLLLMGLFSIYTGFIYNECFSRATTIFPSGWSVAAMANQSGWSDEYLSQHPMLTLNPN 504

  Fly   509 V--ATRGVYPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIIL 571
            :  ...|.||.||||||..|:|.:.|||::|||:|:|.||.||.|||.:|:.|.|.|.:...::|
  Rat   505 ITGVFLGPYPFGIDPIWSLATNHLSFLNSFKMKMSVILGVTHMAFGVFLSIFNHVHFGQAHRLLL 569

  Fly   572 QFVPQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDV 636
            :.||:::|||.:|||:.|::.|||:.      |.|.:...|||:||.||:|.||.....    :.
  Rat   570 ETVPELIFLLGLFGYLVFLIVYKWLY------VSAASASSAPSILIHFINMFLFSQNPT----NR 624

  Fly   637 NMFPIQKNLEMIFLVVALLCIPWILLGKPLYI--KYQRRNRPAGPV-----EEVDEIVEKIEVTT 694
            .:|..|..::...:|:||..:|.:|||.|||:  ::.|||....|.     |:.|:::...:.:|
  Rat   625 LLFHGQVVVQYALVVLALATVPILLLGTPLYLLRQHHRRNTQRRPTAGRQDEDSDKLLASPDAST 689

  Fly   695 GKEIIITEVAEAHESGGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLS 759
            .:.....:..:|..||  .||.:...|||::||||||||:.|..||:||||||||||||||||||
  Rat   690 LENSWSPDEEKAGSSG--DEEAEFVPSEIFMHQAIHTIEFCLGCISNTASYLRLWALSLAHAQLS 752

  Fly   760 EVLWTMVLAMGLQMNGYVG--AIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFY 822
            ||||.||:.:||.|...:|  ::.|..:||.:...|:||:::|||||||||.||||||||.:|||
  Rat   753 EVLWAMVMRIGLGMGREIGVASVVLVPVFAAFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFY 817

  Fly   823 VGNGYPFTPFSF 834
            .|.||..:||:|
  Rat   818 SGTGYKLSPFAF 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	V_ATPase_I	39..834	CDD:460232	325/831 (39%)
Tcirg1	NP_954520.3	V_ATPase_I	27..829	CDD:460232	325/831 (39%)