DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-4 and Tcirg1

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_954520.2	Gene:	Tcirg1 / 293650	RGDID:	735136	Length:	834	Species:	Rattus norvegicus

Alignment Length:	857	Identity:	336/857 - (39%)
Similarity:	501/857 - (58%)	Gaps:	67/857 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |:||||.::|||:.|...:||:.::.|||:|.|:|||||..::|.||:|:.|||||:|||:...:
  Rat     3 SMFRSEEVALVQLLLPTASAYNCVSQLGELGLVEFRDLNESVSAFQRRFVVEVRRCEELEKTFTF 67

  Fly    80 VTAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQV 144
            :..|:.:.| ..|...:...|||.||:::.::...::...|:.::..|...|:....:|.....|
  Rat    68 LREEVQRAG-LTLTPPEGTLPAPPPRDLLRIQEETDRLAQELRDVRGNQQALRAQLHQLQLHSAV 131

  Fly   145 L------------------ERTDQFFSDQESHNFDLNKMGTHRDPEKSNGHLGFVAGVISREREY 191
            |                  |||....:..          |.|.|.:     :.||||.:...:..
  Rat   132 LGQSHAPPMAAVHTEGPTTERTPLLSATP----------GPHADLK-----VNFVAGAVEPCKAA 181

  Fly   192 AFERMLWRISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYP 256
            |.||:|||..||.:.....:.:..|.||.||.......||:.:.|:|:..::||:...||.|::|
  Rat   182 ALERLLWRACRGFLIASFKETEGQLEDPVTGEPATWMTFVISYWGEQIGQKVRKITDCFHCHVFP 246

  Fly   257 CPSSHSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFN 321
            .......|...::.::.:.::||.::.:|....:.||....:.||.....::|||.::.|||..:
  Rat   247 YLEQEEARLRTLQQLQQQSQELQEVLGETERFLSQVLGRVQQLLPPGQVQIRKMKAVHLTLNQCS 311

  Fly   322 VDLGSKCLIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQN 386
            |:...||||.|.|...|:|..|:.||.:||:..|  |.:..:.:..:..|||..|||:||..||.
  Rat   312 VNTTHKCLIAEVWCATRDLPTVQQALQSGSSEEG--VSAVAHRIPCQDMPPTLIRTNRFTSSFQG 374

  Fly   387 LIDAYGIAGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKRLS-KKRGGEIWN 450
            ::||||:..||||||..||.|||||||||||||:|||.::||..|.||:.|.:.: |....|||.
  Rat   375 IVDAYGVGRYREVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMVLTENQPAVKTTQNEIWQ 439

  Fly   451 IFFAGRYIIMLMGLFAMYTGFHYNDIFSKSINVFGTRW-------VNVYNRTTVLTNPTLQLNPS 508
            .||.|||:.:|||||::||||.||:.||::..:|.:.|       .:.::...:..:|.|.|||:
  Rat   440 TFFGGRYLPLLMGLFSIYTGFIYNECFSRATTIFPSGWSVAAMANQSGWSDEYLSQHPMLTLNPN 504

  Fly   509 V--ATRGVYPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIIL 571
            :  ...|.||.||||||..|:|.:.|||::|||:|:|.||.||.|||.:|:.|.|.|.:...::|
  Rat   505 ITGVFLGPYPFGIDPIWSLATNHLSFLNSFKMKMSVILGVTHMAFGVFLSIFNHVHFGQAHRLLL 569

  Fly   572 QFVPQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDV 636
            :.||:::|||.:|||:.|::.|||:.      |.|.:...|||:||.||:|.||.....    :.
  Rat   570 ETVPELIFLLGLFGYLVFLIVYKWLY------VSAASASSAPSILIHFINMFLFSQNPT----NR 624

  Fly   637 NMFPIQKNLEMIFLVVALLCIPWILLGKPLYI--KYQRRNRPAGPV-----EEVDEIVEKIEVTT 694
            .:|..|..::...:|:||..:|.:|||.|||:  ::.|||....|.     |:.|:::...:.:|
  Rat   625 LLFHGQVVVQYALVVLALATVPILLLGTPLYLLRQHHRRNTQRRPTAGRQDEDSDKLLASPDAST 689

  Fly   695 GKEIIITEVAEAHESGGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLS 759
            .:.....:..:|..||  .||.:...|||::||||||||:.|..||:||||||||||||||||||
  Rat   690 LENSWSPDEEKAGSSG--DEEAEFVPSEIFMHQAIHTIEFCLGCISNTASYLRLWALSLAHAQLS 752

  Fly   760 EVLWTMVLAMGLQMNGYVG--AIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFY 822
            ||||.||:.:||.|...:|  ::.|..:||.:...|:||:::|||||||||.||||||||.:|||
  Rat   753 EVLWAMVMRIGLGMGREIGVASVVLVPVFAAFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFY 817

  Fly   823 VGNGYPFTPFSF 834
            .|.||..:||:|
  Rat   818 SGTGYKLSPFAF 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	335/855 (39%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	324/830 (39%)
Tcirg1	NP_954520.2	NtpI	27..829	CDD:224188	324/831 (39%)
Tcirg1	NP_954520.2	V_ATPase_I	28..829	CDD:279793	324/830 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830