DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-4 and Tcirg1

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001129563.1	Gene:	Tcirg1 / 27060	MGIID:	1350931	Length:	834	Species:	Mus musculus

Alignment Length:	854	Identity:	344/854 - (40%)
Similarity:	506/854 - (59%)	Gaps:	61/854 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |:||||.::|||:.|...:||:.::.|||:|.|:|||||..::|.||:|:.:||||:|||:...:
Mouse     3 SMFRSEEVALVQLLLPTGSAYNCVSQLGELGLVEFRDLNESVSAFQRRFVVDVRRCEELEKTFTF 67

  Fly    80 VTAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQV 144
            :..|:.:.| ..|...:...|||.||:::.::...::...|:.::..|...|:....:|.....|
Mouse    68 LREEVQRAG-LTLAPPEGTLPAPPPRDLLRIQEETDRLAQELRDVRGNQQALRAQLHQLRLHSAV 131

  Fly   145 L----------ERTDQFFSDQESHNFDLNKMGTHRDPEKSNGHLGFVAGVISREREYAFERMLWR 199
            |          :.|:..||  |:........|.|.|.:     :.||||.:...:..|.||:|||
Mouse   132 LGQSHSPPVAADHTEGPFS--ETTPLLPGTRGPHSDLK-----VNFVAGAVEPYKAAALERLLWR 189

  Fly   200 ISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSSHSER 264
            ..||.:.....:.:..|.||.||.......||:.:.|:|:..:|||:...||.|::|.......|
Mouse   190 ACRGFLIASFRETEGQLEDPVTGEPATWMTFVISYWGEQIGQKIRKITDCFHCHVFPYLEQEEAR 254

  Fly   265 QEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLGSKCL 329
            ...::.::.:.::||.::.:|....:.||....:.||.|...:.|||.:|.|||..:|:...|||
Mouse   255 FRTLQQLQQQSQELQEVLGETDRFLSQVLGRVQQLLPPWQVQIHKMKAVYLTLNQCSVNTTHKCL 319

  Fly   330 IGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDAYGIA 394
            |.|.|...|:|..|:.||.:||:..|  |.:..:.:..:..|||..|||:||..||.::||||:.
Mouse   320 IAEVWCAARDLPTVQQALQSGSSEEG--VSAVAHRIPCQDMPPTLIRTNRFTSSFQGIVDAYGVG 382

  Fly   395 GYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKRLSKKRG-GEIWNIFFAGRYI 458
            .||||||..||.|||||||||||||:|||.::||..|.||:.|.|.:.|.. .|||..||.|||:
Mouse   383 RYREVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMVLTENRPAVKAAQNEIWQTFFGGRYL 447

  Fly   459 IMLMGLFAMYTGFHYNDIFSKSINVFGTRWVNVYNRTTVLTNPT------------LQLNPSV-- 509
            ::|||||::||||.||:.||::..:|.:.|     ....:.|.:            |.|||::
Mouse   448 LLLMGLFSVYTGFIYNECFSRATTIFPSGW-----SVAAMANQSGWSDEYLSQHSMLTLNPNITG 507

  Fly   510 ATRGVYPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFV 574
            ...|.||.||||||..|:|.:.|||::|||:|:|.||.||.|||.:|:.|.|.|.:...::|:.:
Mouse   508 VFLGPYPFGIDPIWSLATNHLSFLNSFKMKMSVILGVTHMAFGVFLSIFNHVHFGQAHRLLLETL 572

  Fly   575 PQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDVNMF 639
            |:::|||.:|||:.|::.||||      :|.|.:...|||:||.||:|.||.....    :..:|
Mouse   573 PELIFLLGLFGYLVFLIVYKWV------NVSAASASSAPSILIHFINMFLFSQNPT----NHLLF 627

  Fly   640 PIQKNLEMIFLVVALLCIPWILLGKPLYIKYQ---RRN---RPAGPV-EEVDEIVEKIEVTTGKE 697
            ..|:.::.:.:|:||..:|.:|||.|||:..|   |||   ||||.. |:.|:::...:.:|.:.
Mouse   628 HGQEVVQYVLVVLALATVPILLLGTPLYLLRQHRHRRNTQRRPAGQQDEDTDKLLASPDASTLEN 692

  Fly   698 IIITEVAEAHESGGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVL 762
            ....:..:|...|  .||.:...|||::||||||||:.|..||:|||||||||||||||||||||
Mouse   693 SWSPDEEKAGSPG--DEETEFVPSEIFMHQAIHTIEFCLGCISNTASYLRLWALSLAHAQLSEVL 755

  Fly   763 WTMVLAMGLQMNGYVG--AIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGN 825
            |.||:.:||.|...:|  |:.|..:||.:...|:||:::|||||||||.||||||||.:|||.|.
Mouse   756 WAMVMRIGLGMGREIGVAAVVLVPVFAAFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGT 820

  Fly   826 GYPFTPFSF 834
            ||..:||:|
Mouse   821 GYKLSPFTF 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	343/852 (40%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	332/827 (40%)
Tcirg1	NP_001129563.1	NtpI	27..829	CDD:224188	332/828 (40%)
Tcirg1	NP_001129563.1	V_ATPase_I	28..829	CDD:279793	332/827 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1255
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.780