DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-4 and ATP6V0A2

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_036595.2	Gene:	ATP6V0A2 / 23545	HGNCID:	18481	Length:	856	Species:	Homo sapiens

Alignment Length:	871	Identity:	369/871 - (42%)
Similarity:	544/871 - (62%)	Gaps:	82/871 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |:||||.|.|.|::||...||:.::||||.|.|||||||..:::.||||:|||:||:||||.:.|
Human     3 SLFRSETMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERILVY 67

  Fly    80 VTAELNK------EGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLEL 138
            :..|:|:      ||       :..||||..:::::::..|:|.|.|:.|:..|...|:.:.|||
Human    68 LVQEINRADIPLPEG-------EASPPAPPLKQVLEMQEQLQKLEVELREVTKNKEKLRKNLLEL 125

  Fly   139 SEMIQVLERTDQFF--------SDQESHNFDLNKMGTHRDPEKSNGHLGFVAGVISREREYAFER 195
            .|...:|..|..|.        :.:|..:.:.:.:..:...::....||||:|:|::.:..|||:
Human   126 IEYTHMLRVTKTFVKRNVEFEPTYEEFPSLESDSLLDYSCMQRLGAKLGFVSGLINQGKVEAFEK 190

  Fly   196 MLWRISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSS 260
            ||||:.:|...|...::|.:|.||:||.|:...||::.|.|:|:..:::|:|..:|.|:||.|::
Human   191 MLWRVCKGYTIVSYAELDESLEDPETGEVIKWYVFLISFWGEQIGHKVKKICDCYHCHVYPYPNT 255

  Fly   261 HSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLG 325
            ..||:|:.:.:.||::||..::::|.|:...||..|.:.:.:....|||||.|||.||:.:.|:.
Human   256 AEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVYSRVIQVKKMKAIYHMLNMCSFDVT 320

  Fly   326 SKCLIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDA 390
            :||||.|.|.|:.:|:.:..||..||...|:|:|||:|::.||:.|||..||||||.||||::||
Human   321 NKCLIAEVWCPEADLQDLRRALEEGSRESGATIPSFMNIIPTKETPPTRIRTNKFTEGFQNIVDA 385

  Fly   391 YGIAGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKRLSKKRGGEIWNIFFAG 455
            ||:..||||||.|:|.|||||||||||||.|||.::||..|.:|::|......:..||..:||.|
Human   386 YGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENHPRLNQSQEIMRMFFNG 450

  Fly   456 RYIIMLMGLFAMYTGFHYNDIFSKSINVFGTRWVNV------------------YNRTTVLTNPT 502
            |||::|||||::|||..|||.||||:|:||:.| ||                  :|.:.|..|..
Human   451 RYILLLMGLFSVYTGLIYNDCFSKSVNLFGSGW-NVSAMYSSSHPPAEHKKMVLWNDSVVRHNSI 514

  Fly   503 LQLNPSV--ATRGVYPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKK 565
            |||:||:  ..||.||:||||||..|:|::.|||::|||:|:|.|::||.|||.:.:.|.:.|:|
Human   515 LQLDPSIPGVFRGPYPLGIDPIWNLATNRLTFLNSFKMKMSVILGIIHMTFGVILGIFNHLHFRK 579

  Fly   566 YAYIILQFVPQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLF---KT 627
            ...|.|..:|::||:|.:|||:.||:||||:.:|      |:|...|||:||.||:|.||   ||
Human   580 KFNIYLVSIPELLFMLCIFGYLIFMIFYKWLVFS------AETSRVAPSILIEFINMFLFPASKT 638

  Fly   628 ETALPGCDVNMFPIQKNLEMIFLVVALLCIPWILLGKPLYIKYQRRNRPAGPVEEV------DEI 686
            .....|        |:.::.:.|||..|.:|.:.|||||::.:....|....|...      .:.
Human   639 SGLYTG--------QEYVQRVLLVVTALSVPVLFLGKPLFLLWLHNGRSCFGVNRSGYTLIRKDS 695

  Fly   687 VEKIEVTTGKEIIITEVAEAHESGGHSEED--------DEPMSEIWIHQAIHTIEYILSTISHTA 743
            .|::.:...::|         |.|.|..||        :....||.:.|.||:|||.|..||:||
Human   696 EEEVSLLGSQDI---------EEGNHQVEDGCREMACEEFNFGEILMTQVIHSIEYCLGCISNTA 751

  Fly   744 SYLRLWALSLAHAQLSEVLWTMVLAMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLH 808
            ||||||||||||||||:|||.|::.:||:::...|.:.|..:.|::...||.|:::|||||||||
Human   752 SYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLH 816

  Fly   809 TLRLHWVEFMSKFYVGNGYPFTPFSF 834
            .:|||||||.:|||||.|..|.||||
Human   817 AIRLHWVEFQNKFYVGAGTKFVPFSF 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	368/869 (42%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	355/844 (42%)
ATP6V0A2	NP_036595.2	V_ATPase_I	27..842	CDD:307581	355/845 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830