DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-4 and Atp6v0a2

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_035726.2	Gene:	Atp6v0a2 / 21871	MGIID:	104855	Length:	856	Species:	Mus musculus

Alignment Length:	864	Identity:	367/864 - (42%)
Similarity:	539/864 - (62%)	Gaps:	68/864 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |:||||.|.|.|::||...||:.::||||.|.|||||||..:::.||||:|||:||:||||.:.|
Mouse     3 SLFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERILVY 67

  Fly    80 VTAELNK------EGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLEL 138
            :..|:.:      ||       :..||||..:.:::::..|:|.|.|:.|:..|...|:.:.|||
Mouse    68 LVQEITRADIPLPEG-------EASPPAPPLKHVLEMQEQLQKLEVELREVTKNKEKLRKNLLEL 125

  Fly   139 SEMIQVLERTDQFF--------SDQESHNFDLNKMGTHRDPEKSNGHLGFVAGVISREREYAFER 195
            .|...:|..|..|.        :.:|....:.:.:..:...::....||||:|:|.:.|..||||
Mouse   126 VEYTHMLRVTKTFLKRNVEFEPTYEEFPALENDSLLDYSCMQRLGAKLGFVSGLIQQGRVEAFER 190

  Fly   196 MLWRISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSS 260
            ||||..:|...|...::|..|.||:||.|:...||::.|.|:|:..:::|:|..:|.|:||.|::
Mouse   191 MLWRACKGYTIVTYAELDECLEDPETGEVIKWYVFLISFWGEQIGHKVKKICDCYHCHIYPYPNT 255

  Fly   261 HSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLG 325
            ..||:|:.:.:.||::||..::::|.|:...||..|.:.:.:....|:|||.|||.||:.:.|:.
Mouse   256 AEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVCSRVVQVRKMKAIYHMLNMCSFDVT 320

  Fly   326 SKCLIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDA 390
            :||||.|.|.|:.:|..:..||..||...|:|:|||:|.:.||:.|||..||||||.||||::||
Mouse   321 NKCLIAEVWCPEVDLPGLRRALEEGSRESGATIPSFMNTIPTKETPPTLIRTNKFTEGFQNIVDA 385

  Fly   391 YGIAGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEK--RLSKKRGGEIWNIFF 453
            ||:..||||||.|:|.|||||||||||||.|||.::||..|.:|::|.  |||:.:  ||..:||
Mouse   386 YGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENHPRLSQSQ--EILRMFF 448

  Fly   454 AGRYIIMLMGLFAMYTGFHYNDIFSKSINVFGTRWVNV------------------YNRTTVLTN 500
            .||||::|||||::|||..|||.||||:|:||:.| ||                  :|.:|:..:
Mouse   449 DGRYILLLMGLFSVYTGLIYNDCFSKSVNLFGSGW-NVSAMYSSSHSPEEQRKMVLWNDSTIRHS 512

  Fly   501 PTLQLNPSV--ATRGVYPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFF 563
            .||||:|::  ..||.||.||||||..|:|::.|||::|||:|:|.|:.||.|||.:.:.|.:.|
Mouse   513 RTLQLDPNIPGVFRGPYPFGIDPIWNLATNRLTFLNSFKMKMSVILGIFHMTFGVVLGIFNHLHF 577

  Fly   564 KKYAYIILQFVPQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTE 628
            :|...:.|..||::||:|.:|||:.||:.|||:.||..|..|      |||:||.||:|.||.|.
Mouse   578 RKKFNVYLVSVPEILFMLCIFGYLIFMIIYKWLAYSAETSRE------APSILIEFINMFLFPTS 636

  Fly   629 TALPGCDVNMFPIQKNLEMIFLVVALLCIPWILLGKPLYIKYQRRNRPA-GPVEEVDEIVEKIEV 692
            ..     ..::|.|.:::.:.:.:.:|.:|.:.|||||::.:....|.. |.......:|.|
Mouse   637 KT-----HGLYPGQAHVQRVLVALTVLAVPVLFLGKPLFLLWLHNGRNCFGMSRSGYTLVRK--- 693

  Fly   693 TTGKEIIITEVAEAHESGGHSEE-------DDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWA 750
            .:.:|:.:....:..|.....||       ::....||.:.||||:|||.|..||:|||||||||
Mouse   694 DSEEEVSLLGNQDIEEGNSRMEEGCREVTCEEFNFGEILMTQAIHSIEYCLGCISNTASYLRLWA 758

  Fly   751 LSLAHAQLSEVLWTMVLAMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWV 815
            |||||||||:|||.|::.:||:::...|.:.|..:.|.:...||.|:::|||||||||.:|||||
Mouse   759 LSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVMAFFAVLTIFILLVMEGLSAFLHAIRLHWV 823

  Fly   816 EFMSKFYVGNGYPFTPFSF 834
            ||.:|||||.|..|.||||
Mouse   824 EFQNKFYVGAGTKFVPFSF 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	366/862 (42%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	353/837 (42%)
Atp6v0a2	NP_035726.2	NtpI	5..839	CDD:224188	362/857 (42%)
Atp6v0a2	NP_035726.2	V_ATPase_I	28..839	CDD:279793	351/834 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820