DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-4 and vha-5

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_501399.1	Gene:	vha-5 / 177626	WormBaseID:	WBGene00006914	Length:	873	Species:	Caenorhabditis elegans

Alignment Length:	872	Identity:	363/872 - (41%)
Similarity:	532/872 - (61%)	Gaps:	55/872 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |:.|||.|...|:.::.:||::.:|.:|:...|||:|||..:|:.||.|:.::||.||:||::|:
Worm     3 SLSRSEEMRFCQLIVEKDAAFNIVAEIGKQPYVQFKDLNPNVNSFQRTFVKDIRRYDEMERKLRF 67

  Fly    80 VTAELNKEGHKVLDLMD--DFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMI 142
            :.:::.|:...:...:|  |:...| ..|:..||..|.:.|.::..:..::..|:.::::|.|..
Worm    68 LESQIVKDEIVIPGRVDTGDYTILP-TSELNTLEGTLTELEKDVKSMNDSDSQLKANFMDLKEWD 131

  Fly   143 QVLERTDQFF----SDQESHNFD-LNKMGTHRDPEKSNGHLGFVAGVISREREYAFERMLWRISR 202
            .||::||:||    .||.....: |::.|.  .|....|.:.::.|:|.|||...|||:|||...
Worm   132 AVLDKTDEFFQGGVDDQAQEELENLDEEGA--VPRVEKGPVNYLVGIIRRERLNGFERVLWRACH 194

  Fly   203 GNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYP-CPSSHSERQE 266
            ...::|..|::..|.||.||..:|||||::|.:||::::.:.|||.||.|.::. ||.:..|||.
Worm   195 HTAYIRSSDIEEELEDPGTGEKVHKSVFIIFLKGDRMRSIVEKVCDGFKAKLFKNCPKTFKERQS 259

  Fly   267 MVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLGSKCLIG 331
            ...:||.|::|||.::.||.:||..|||||......|...|:.:|.::|.||||..|...:..:|
Worm   260 ARNDVRARIQDLQTVLGQTREHRFRVLQAAANNHHQWLKQVRMIKTVFHMLNLFTFDGIGRFFVG 324

  Fly   332 EGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDAYGIAGY 396
            |.|:|.:.:|.|..|:..|:...||:|...:|:|:|...|||:..|||||..||.::|:||||.|
Worm   325 ECWIPLKHVEDVRKAIEVGAERSGSSVKPVLNILETSVTPPTYNETNKFTAVFQGIVDSYGIATY 389

  Fly   397 REVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKRLSKKR-GGEIWNIFFAGRYIIM 460
            ||:||..||.|||||||:.||||:|||.|:.:.|||.|:.||.|..:. ..||:|:||.|||||:
Worm   390 RELNPAPYTIITFPFLFSCMFGDLGHGCIMLMAGLWFVLREKNLQARNIKDEIFNMFFGGRYIIL 454

  Fly   461 LMGLFAMYTGFHYNDIFSKSINVFGTRWVNVYNRTTV--LTNPT-------LQLNPSVA---TRG 513
            |||||:::.|..|||:|:||.|:||:.|.|.||.:.:  ..|.|       ::|.|..|   ..|
Worm   455 LMGLFSIHAGIIYNDMFAKSFNIFGSGWKNPYNASEIEGWINRTEHGKEMLVELAPEDAYDHAGG 519

  Fly   514 VYPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFVPQVL 578
            .|..|:||||..|.||:.|||:.|||||:|.|:..|.|||.:|..|..:.|....|...|:||:|
Worm   520 PYSFGVDPIWNIAENKLNFLNSMKMKLSVILGISQMTFGVILSFFNHTYNKSKIDIFTVFIPQML 584

  Fly   579 FLLLMFGYMCFMMFYKWVKY--SPTTDVEADTPG--CAPSVLIMFIDMVLFKTETA---LPGCDV 636
            |:..:|.|:|..:..||:.:  ...|......||  ||||:||..|:|.:.|...|   :.|..|
Worm   585 FMGCIFMYLCLQIILKWLFFWTKEATVFGQIYPGSHCAPSLLIGLINMFMMKDRNAGFVVDGGKV 649

  Fly   637 N-------------MFPIQKNLEMIFLVVALLCIPWILLGKPLYIKYQRRNRPAGPVEEV--DEI 686
            |             .:|.|..:|||.:|:|::|:|.:|.|||::...|::.:    .:|:  :..
Worm   650 NGEYREVETCYLSQWYPGQSVIEMILVVIAVICVPVMLFGKPIHHVMQQKKK----AKELHGNAT 710

  Fly   687 VEKIEVTTGKEIIIT----EVAEAHESGGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLR 747
            |....|:...||::.    :...|||..||...:||...:|.:|||||||||:|..:||||||||
Worm   711 VRANVVSDSSEIVLNGGSKKEGAAHEEHGHGGHEDESFGDIMVHQAIHTIEYVLGCVSHTASYLR 775

  Fly   748 LWALSLAHAQLSEVLWTMVLAM-GLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLR 811
            ||||||||||||||||.||... ||.::|..|.|.::.:|.::...||:|:|:||||||||||||
Worm   776 LWALSLAHAQLSEVLWHMVFVTGGLGISGTAGFIAVYVVFFIFFVLTISILVLMEGLSAFLHTLR 840

  Fly   812 LHWVEFMSKFYVGNGYPFTPFSFKDIL 838
            ||||||.||||:|.||||.|:|||..|
Worm   841 LHWVEFQSKFYLGLGYPFVPYSFKTAL 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	360/866 (42%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	350/841 (42%)
vha-5	NP_501399.1	V_ATPase_I	28..863	CDD:279793	350/841 (42%)
vha-5	NP_501399.1	NtpI	35..864	CDD:224188	350/835 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830