DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-4 and unc-32

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001023017.1	Gene:	unc-32 / 176257	WormBaseID:	WBGene00006768	Length:	905	Species:	Caenorhabditis elegans

Alignment Length:	899	Identity:	404/899 - (44%)
Similarity:	567/899 - (63%)	Gaps:	65/899 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKWWSCGSNQESNSIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIG 65
            |..:.:.|.......|:|||.|.|.|:|||.:|:|..:|.|||:|.|||||||..:::.|||::.
Worm     1 MGDYVTPGEEPPQPGIYRSEQMCLAQLYLQSDASYQCVAELGELGLVQFRDLNPDVSSFQRKYVN 65

  Fly    66 EVRRCDELERRIRYVTAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVN 130
            |||||||:||::||:..|:.|:...:||..:: |.||.|||:||||...||.|.|:.|:..|...
Worm    66 EVRRCDEMERKLRYLEREIKKDQIPMLDTGEN-PDAPLPREMIDLEATFEKLENELREVNKNEET 129

  Fly   131 LQTSYLELSEMIQVLERTDQFFSDQESHNFDLNKMGTHR-----------------DPEKSNG-- 176
            |:.::.||:|:..:|.:|..||.:.:...:.:.:.|:.|                 |.:..:.
Worm   130 LKKNFSELTELKHILRKTQTFFEEVDHDRWRILEGGSGRRGRSTEREETRPLIDIGDMDDDSAAR 194

  Fly   177 --------HLGFVAGVISREREYAFERMLWRISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVF 233
                    .||||||||.|||..||||:|||..|||||:|..::|..|.|..||:.::|.||::|
Worm   195 MSAQAAMLRLGFVAGVIQRERLPAFERLLWRACRGNVFLRTSEIDDVLNDTVTGDPVNKCVFIIF 259

  Fly   234 FQGDQLQARIRKVCTGFHAHMYPCPSSHSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALK 298
            ||||.|:.:::|:|.||.|.:||||.:..||:||...|.||:|||:.::.||.|||..||.||.|
Worm   260 FQGDHLKTKVKKICEGFRATLYPCPDTPQERREMSIGVMTRIEDLKTVLGQTQDHRHRVLVAASK 324

  Fly   299 QLPTWSAMVKKMKGIYHTLNLFNVDLGSKCLIGEGWVPKRELELVEVALAAGSASVGSTVPSFIN 363
            .:..|...|:|:|.|||||||||:|:..||||.|.|.|..||:.:::||..|:...||.|||.:|
Worm   325 NVRMWLTKVRKIKSIYHTLNLFNIDVTQKCLIAEVWCPIAELDRIKMALKRGTDESGSQVPSILN 389

  Fly   364 VLDTKKEPPTHFRTNKFTRGFQNLIDAYGIAGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFL 428
            .::|.:.|||:.:|||||:||||::||||||.|||:||..||.|:|||||||||||||||.|:.|
Worm   390 RMETNEAPPTYNKTNKFTKGFQNIVDAYGIATYREINPAPYTMISFPFLFAVMFGDMGHGAIMLL 454

  Fly   429 LGLWMVIDEKRLSKKR-GGEIWNIFFAGRYIIMLMGLFAMYTGFHYNDIFSKSINVFGTRWVNVY 492
            ..|:.::.||:|...| ..||:..||.|||:|.|||.|::||||.|||:||||||.||:.|.|..
Worm   455 AALFFILKEKQLEAARIKDEIFQTFFGGRYVIFLMGAFSIYTGFMYNDVFSKSINTFGSSWQNTI 519

  Fly   493 NRTTV--------LTNPTLQLNPSVATRG-VYPMGIDPIWQSA-SNKIIFLNTYKMKLSIIFGVL 547
            ..:.:        .:...|.|.|..|..| .||:|:||:|..| .||:.|||:.|||:|::||:.
Worm   520 PESVIDYYLDDEKRSESQLILPPETAFDGNPYPIGVDPVWNLAEGNKLSFLNSMKMKMSVLFGIA 584

  Fly   548 HMVFGVCMSVENFVFFKKYAYIILQFVPQVLFLLLMFGYMCFMMFYKWVKYSPT--TDVEADTPG 610
            .|.|||.:|.:||::||....|...|:||::||..:|.|:|..:..||:.:...  |.:....||
Worm   585 QMTFGVLLSYQNFIYFKSDLDIKYMFIPQMIFLSSIFIYLCIQILSKWLFFGAVGGTVLGYKYPG 649

  Fly   611 --CAPSVLIMFIDMVLFKTETA---------LPGCDVN-MFPIQKNLEMIFLVVALLCIPWILLG 663
              ||||:||..|:|.:.|:..|         .|.|.:: .:|.|..:|:|.:|:||:.:|.:|..
Worm   650 SNCAPSLLIGLINMFMMKSRNAGFVDDSGETYPQCYLSTWYPGQATIEIILVVLALVQVPIMLFA 714

  Fly   664 KP--LYIKYQRRNRPAGPVEEVDEIVEKIEVTTGKEIIITEVAEAHE-----SG-GHSEEDDE-P 719
            ||  ||.:.::::|.:....|.:: .:.:.....::  ..||..|.|     || ||...|.. .
Worm   715 KPYFLYRRDKQQSRYSTLTAESNQ-HQSVRADINQD--DAEVVHAPEQTPKPSGHGHGHGDGPLE 776

  Fly   720 MSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLWTMVLAMGLQMNGYVGAIGLFF 784
            |.::.::|||||||::|..:||||||||||||||||||||:||||||......::||.|||..:.
Worm   777 MGDVMVYQAIHTIEFVLGCVSHTASYLRLWALSLAHAQLSDVLWTMVFRNAFVLDGYTGAIATYI 841

  Fly   785 IFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNGYPFTPFSFKDIL 838
            :|.::...::.|:|:|||||||||.||||||||.||||.|.||.|.||||:.||
Worm   842 LFFIFGSLSVFILVLMEGLSAFLHALRLHWVEFQSKFYGGLGYEFAPFSFEKIL 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	399/879 (45%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	385/854 (45%)
unc-32	NP_001023017.1	NtpI	40..892	CDD:224188	386/855 (45%)
unc-32	NP_001023017.1	V_ATPase_I	40..891	CDD:279793	385/854 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160167
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860