DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-4 and TCIRG1

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	XP_024304088.1	Gene:	TCIRG1 / 10312	HGNCID:	11647	Length:	861	Species:	Homo sapiens

Alignment Length:	959	Identity:	290/959 - (30%)
Similarity:	423/959 - (44%)	Gaps:	244/959 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |:||||.::|||::|...|||..::.|||:|.|:||||||.::|.||:|:.:||||:|||:...:
Human     3 SMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEELEKTFTF 67

  Fly    80 VTAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQV 144
            :..|:.:.| .||.......|||.||:::.::...|:...|:.::..|...|:....:|.....|
Human    68 LQEEVRRAG-LVLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRAQLHQLQLHAAV 131

  Fly   145 LERTDQ-----FFSDQESHNFDLNKM--GTHRDPEKSNGHLGFVAGVISREREYAFERMLWRISR 202
            |.:..:     ..:|..|....|.:.  |.|:|.     .:.||||.:...:..|.||:|||..|
Human   132 LRQGHEPQLAAAHTDGASERTPLLQAPGGPHQDL-----RVNFVAGAVEPHKAPALERLLWRACR 191

  Fly   203 GNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSSHSERQEM 267
            |.:.....:::..|..|.||.......|::.:.|:|:..:|||:.        .|.||
Human   192 GFLIASFRELEQPLEHPVTGEPATWMTFLISYWGEQIGQKIRKIT--------DCASS------- 241

  Fly   268 VKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLG------- 325
                                     ||..|.:||..:|.....:|............|
Human   242 -------------------------LQLPLPRLPVSAAGGGPPRGPAAAATAEPGAAGGPRGDRA 281

  Fly   326 --------------SKCLIG---EGWVP-----KRELE--------LVEVALAA----------- 349
                          ::...|   ||.||     :||..        ||..|..|
Human   282 VPEPGARPGAAAAAARAGAGPQDEGRVPGPEPVQREHHAQVPHCRGLVLCARPARPAGGPAGQLD 346

  Fly   350 --GSASVGSTVPSFINVLDTKKEPPTH---------FRTNKFTRGFQNLI-----------DAYG 392
              ||...||..|...:...|....|.|         .|......|....:           |..|
Human   347 GGGSECRGSPHPLPGHAPHTHPHQPLHGQLPGHRGCLRRGPLPGGQPRSLHHHHLPLPVCCDVRG 411

  Fly   393 I---AGYREVNPGLYTC-----------------ITFPFLFAVMFGDMGHGTILFLLGLWMVIDE 437
            .   |.:..|.||...|                 :..| |.|..:|.:.|   |..|.|..|:..
Human   412 CGPRAAHVPVRPGHGPCGEPTGCEGRAERDLADFLQGP-LPAPAYGPVLH---LHRLHLQRVLQS 472

  Fly   438 KRLSKKRGGEIWNIFFAGRYIIMLMGLFAMYTGFHYNDIFSKSINVFGTRWVNVY--------NR 494
            :......|.|                     .|.|...:           |:.|.        .|
Human   473 RHQHLPLGLE---------------------CGRHGQPV-----------WLEVRPGPQPGWGPR 505

  Fly   495 TT---------------VLTNPTLQLNPSV--ATRGVYPMGIDPIWQSASNKIIFLNTYKMKLSI 542
            :|               :..:..|.|:|:|  ...|.||.||||||..|:|.:.|||::|||:|:
Human   506 STRSPDRPPLRCRSDAFLAQHTMLTLDPNVTGVFLGPYPFGIDPIWSLAANHLSFLNSFKMKMSV 570

  Fly   543 IFGVLHMVFGVCMSVENFVFFKKYAYIILQFVPQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEAD 607
            |.||:||.|||.:.|.|.|.|.:...::|:.:|::.|||.:|||:.|::.|||:      .|.|.
Human   571 ILGVVHMAFGVVLGVFNHVHFGQRHRLLLETLPELTFLLGLFGYLVFLVIYKWL------CVWAA 629

  Fly   608 TPGCAPSVLIMFIDMVLFKTETALPGCDVNMFPIQKNLEMIFLVVALLCIPWILLGKPLYIKYQR 672
            ....|||:||.||:|.||....:    :..::|.|:.::...:|:||..:|.:|||.||::.::.
Human   630 RAASAPSILIHFINMFLFSHSPS----NRLLYPRQEVVQATLVVLALAMVPILLLGTPLHLLHRH 690

  Fly   673 ----RNRPAGPVEEVDEIVEKIEVTTGKEIIITEVAEAHESGGHSEE------DDEP-----MSE 722
                |.|||...||             .:..:.::.:|..:|..|:|      |||.     .||
Human   691 RRRLRRRPADRQEE-------------NKAGLLDLPDASVNGWSSDEEKAGGLDDEEEAELVPSE 742

  Fly   723 IWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLWTMVLAMGLQMNGYVG--AIGLFFI 785
            :.:||||||||:.|..:|:||||||||||||||||||||||.||:.:||.:...||  |:.|..|
Human   743 VLMHQAIHTIEFCLGCVSNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGLGREVGVAAVVLVPI 807

  Fly   786 FAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNGYPFTPFSF 834
            ||.:...|:||:::|||||||||.||||||||.:|||.|.||..:||:|
Human   808 FAAFAVMTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLSPFTF 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	289/957 (30%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	277/932 (30%)
TCIRG1	XP_024304088.1	V_ATPase_I	27..>238	CDD:332370	66/224 (29%)
		SelP_N	<357..400	CDD:309645	6/42 (14%)
		V_ATPase_I	<541..856	CDD:332370	151/337 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1255
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.780