DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-4 and si:ch73-173p19.2

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	XP_021326052.1	Gene:	si:ch73-173p19.2 / 100332691	ZFINID:	ZDB-GENE-141212-282	Length:	831	Species:	Danio rerio

Alignment Length:	853	Identity:	360/853 - (42%)
Similarity:	534/853 - (62%)	Gaps:	60/853 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRYV 80
            :||||.|.|||::||.|:|::.|..||.:|.|||:|||....|.||:|:.||::|:::||.:||:
Zfish     5 LFRSEEMCLVQLFLQTESAHNCINELGHLGLVQFKDLNPCATAFQRRFVKEVKKCEQMERILRYL 69

  Fly    81 TAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQVL 145
            ..|:.| .:.|:....:....|..|::::||...||.|.|:.|:..|:..|:.:.:||.::..:|
Zfish    70 EKEMVK-SNIVITATKEKEMVPCARDVLELESTFEKLEQELREINHNHDTLRQNLIELMDIDSLL 133

  Fly   146 ERTDQFFSDQES-------HNFDLNKM------GTHRDPEKSNG---HLGFVAGVISREREYAFE 194
            ..|:.||.:.||       .::|...|      .:.|:...|..   ||||:||||.:||..|||
Zfish   134 RMTEDFFEEAESLLTFSEASSYDSVSMTISSFITSRRNSSSSTSGPLHLGFIAGVIKQERFPAFE 198

  Fly   195 RMLWRISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPS 259
            ::|||:..||..:|..::............:.|..|::|.|||.::.:|||||.||.|.:|.||.
Zfish   199 KVLWRLFHGNFVLRHAEIQTTEELEAVRGAVKKDAFIIFVQGDHVREKIRKVCEGFRASLYSCPK 263

  Fly   260 SHSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDL 324
            :..||:||..::.||:|||::::.:|.::|..||..|.:.:..|.:.|||||.||:||||.|:|:
Zfish   264 TLYERKEMSNSIMTRMEDLRLVLRRTEEYRAGVLSRAAEHVQEWGSKVKKMKAIYYTLNLCNIDI 328

  Fly   325 GSKCLIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLID 389
            ..|.::.|.|.|..:|.:|:.||..||...||:|...:|.:.||:.|||..|||.||.|||.:||
Zfish   329 TQKLIVAEIWCPVSDLTVVQNALIKGSEQSGSSVTPVLNRIQTKQTPPTFNRTNSFTEGFQAIID 393

  Fly   390 AYGIAGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKRLSKKRGGEIWNIFFA 454
            |||:..|:|:||..||.|||||||||||||.|||.::.|..:|::.....:.|.: .|:.::...
Zfish   394 AYGVGTYQEINPAPYTIITFPFLFAVMFGDCGHGLLMALFSVWLITQADYIRKWK-NELTDVLVG 457

  Fly   455 GRYIIMLMGLFAMYTGFHYNDIFSKSINVFGTRWV--------NVYNRTTVLTNPTLQLNPSVAT 511
            ||:||:|||||::|||..|||.||||.|:||:.|.        ..:...|:..:..|||||.|.
Zfish   458 GRFIILLMGLFSIYTGLIYNDCFSKSFNIFGSSWCVRPMFHPHGSWQNETLHDHHHLQLNPFVP- 521

  Fly   512 RGV-----YPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIIL 571
             ||     |..||||||..||||:.|||::|||:|:|.||.||:|||.:|:.||:.|:|:..|:|
Zfish   522 -GVFSGHPYVFGIDPIWNIASNKLSFLNSFKMKMSVILGVAHMLFGVTLSLVNFLHFRKFQDILL 585

  Fly   572 QFVPQVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDV 636
            |||||::|:|.:|||:.|::.||| ..|.::::       |||:|::||.|:||..:   |...:
Zfish   586 QFVPQLVFMLCLFGYLIFLILYKW-SVSLSSEM-------APSILLLFISMMLFDYQ---PDHKL 639

  Fly   637 NMFPIQKNLEMIFLVVALLCIPWILLGKPLYIKYQRRNRPAGPVEEVDEIVEKIEVTTGKEIIIT 701
             ::..||.:::..:|.|:|.:|.:||.||..| |:.|.:....|             .|..:...
Zfish   640 -LYGGQKAVQICLVVTAVLMVPVLLLVKPFLI-YRSRMKTRHQV-------------FGNSLDDQ 689

  Fly   702 EVAEAHES-GGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLWTM 765
            :..:...| ..|.:::...|.:::::||||||||.|..||:|||||||||||||||:||||||.|
Zfish   690 QCTDKRSSFARHQKDETVSMGDVFVYQAIHTIEYCLGCISNTASYLRLWALSLAHAELSEVLWRM 754

  Fly   766 VLAMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNGYPFT 830
            ||..||:::..:|::.|..:||.:...|:.::::|||||||||.||||||||.:|||.|:||.||
Zfish   755 VLQAGLKLSFGLGSLMLALLFAAFAVLTVTVLLVMEGLSAFLHALRLHWVEFQNKFYEGSGYKFT 819

  Fly   831 PFSFKDIL 838
            |.||..:|
Zfish   820 PLSFDSLL 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	359/848 (42%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	344/823 (42%)
si:ch73-173p19.2	XP_021326052.1	V_ATPase_I	28..823	CDD:307581	344/824 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930