DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-4 and atp6v0a4

DIOPT Version :9

Sequence 1:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001107162.1	Gene:	atp6v0a4 / 100135019	XenbaseID:	XB-GENE-493197	Length:	846	Species:	Xenopus tropicalis

Alignment Length:	871	Identity:	411/871 - (47%)
Similarity:	562/871 - (64%)	Gaps:	80/871 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79
            |:||||.|||.|:.||.||.|..||.|||:|.||||||||.:|:.||:|:.|||||:.:||.:|:
Frog     3 SLFRSEEMSLTQLILQVEAGYCCIAELGELGLVQFRDLNASVNSFQRRFVNEVRRCENMERILRF 67

  Fly    80 VTAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQV 144
            :.:|:..:..|: ...:..|..|.|||:||||..|||.|.|:.|:..|...|:.::|||:|:..:
Frog    68 LESEMVNDKIKI-RTPEKLPQTPLPREMIDLETVLEKLEGELQEVNRNQQALKQNFLELTELKHL 131

  Fly   145 LERT-----------DQFFSDQESHNFDLNKMGTHRDPEKSNGHLGFVAGVISREREYAFERMLW 198
            |::|           |.|||:..|...:|..:.:    ..:.|.|||.||||:|||...|||:||
Frog   132 LKKTQDFFEAEANLPDDFFSEDTSSLLELRTIPS----AAAAGKLGFTAGVINRERMATFERLLW 192

  Fly   199 RISRGNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSSHSE 263
            |:.|||::::..::|.||.||.|...:.|:||::|:|||||:.:|:|:|.||.|.:||||.|.:|
Frog   193 RVCRGNIYLKYTELDTALEDPVTKEEVKKNVFIIFYQGDQLKLKIKKICDGFKATVYPCPESATE 257

  Fly   264 RQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLGSKC 328
            |:|||.:|.||:|||..:|.||..||..||..|.:.|.:|...|||||.:||.|||.|:|:..:|
Frog   258 RKEMVADVNTRIEDLNTVITQTESHRQRVLLEAAQSLCSWGIKVKKMKAVYHVLNLCNIDVTQQC 322

  Fly   329 LIGEGWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDAYGI 393
            :|.|.|.|..:.|.::.||..|....|||:...:..:.:|.:|||..||||||.||||:::|||:
Frog   323 VIAEIWCPIADKEQIKQALHRGMERSGSTIAPILTNISSKLDPPTFNRTNKFTSGFQNIVNAYGV 387

  Fly   394 AGYREVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKR-LSKKRGGEIWNIFFAGRY 457
            ..|||:||..||.|||||||||||||.|||:::....||||::||: |:.|...||||.||.|||
Frog   388 GSYREMNPTPYTIITFPFLFAVMFGDCGHGSVMLGFALWMVLNEKQLLASKTDNEIWNTFFGGRY 452

  Fly   458 IIMLMGLFAMYTGFHYNDIFSKSINVFGTRW------VN-VYNRTTVLTNPTLQLNPSVATRGV- 514
            :|:||.:|::||||.|||.||||.::||:.|      :| .:|...|.....|||:|:|.  ||
Frog   453 LILLMSIFSIYTGFIYNDCFSKSFDIFGSSWRVRPMFINKTWNDNLVHQGLQLQLDPAVP--GVY 515

  Fly   515 ----YPMGIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFVP 575
                ||.||||||..|.||:.|||:||||:|::.|:..|||||.:.:.|.:.||:...|||||||
Frog   516 SGNPYPFGIDPIWNIAQNKLTFLNSYKMKMSVVMGITQMVFGVMLGLLNHINFKRPINIILQFVP 580

  Fly   576 QVLFLLLMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLF--KTETALPGCDVNM 638
            :::|::.:|||:.||:.:||.||    ||.:...  |||:||.||:|.||  ...|..|     :
Frog   581 EMIFIICLFGYLVFMIIFKWCKY----DVHSSQG--APSILIHFINMFLFNYSDPTNAP-----L 634

  Fly   639 FPIQKNLEMIFLVVALLCIPWILLGKPL-----YIKYQRR-NRPAGPVEEVDEIVEKIEVTTGKE 697
            :..||.::...::.||:.:||:||.||.     ::|.||. ...:||.:..:
Frog   635 YEHQKEVQTFLVIFALIAVPWMLLIKPFVLRANHLKAQRMLQSSSGPEDHAE------------- 686

  Fly   698 IIITEVAEAH--------------ESGGHSEEDDE-PMSEIWIHQAIHTIEYILSTISHTASYLR 747
              :|:|..||              ..|||.|..:| ...:|::|||||||||.|..||:||||||
Frog   687 --LTDVENAHANHKSKKEEHGGGDHGGGHGEHGEEFDFGDIFVHQAIHTIEYCLGCISNTASYLR 749

  Fly   748 LWALSLAHAQLSEVLWTMVLAMGLQMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRL 812
            |||||||||||||||||||:..||.:.||.|.||:|.|||.:...|:||:::|||||||||.|||
Frog   750 LWALSLAHAQLSEVLWTMVMHQGLSIGGYGGLIGVFIIFAAFAVLTVAILLVMEGLSAFLHALRL 814

  Fly   813 HWVEFMSKFYVGNGYPFTPFSFKDIL 838
            |||||.:|||.|.|:.|:||||:.||
Frog   815 HWVEFQNKFYAGTGHLFSPFSFQSIL 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	408/865 (47%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	391/840 (47%)
atp6v0a4	NP_001107162.1	NtpI	26..838	CDD:224188	395/844 (47%)
atp6v0a4	NP_001107162.1	V_ATPase_I	28..836	CDD:279793	391/840 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11629
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.110