DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14309 and Hpse

DIOPT Version :9

Sequence 1:	NP_650718.2	Gene:	CG14309 / 42212	FlyBaseID:	FBgn0038611	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_072127.1	Gene:	Hpse / 64537	RGDID:	61969	Length:	536	Species:	Rattus norvegicus

Alignment Length:	367	Identity:	80/367 - (21%)
Similarity:	143/367 - (38%)	Gaps:	77/367 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 PD-DWDSMHTLKILNTSYMVGITDCIWQLGTD------------FGTSRAKDYVQELRTLKLMTD 167
            || .|:|.:...:||.....|. :..|:||.:            .|....:|:|:..:.|:
  Rat   188 PDLRWNSSNAQLLLNYCSSKGY-NISWELGNEPNSFWKKAQISIDGLQLGEDFVELHKLLQ---- 247

  Fly   168 TFKPYVDDWRLMGADIS--AGSSADETKRYVDMSKDLNTAFGW---------TQPANMLPKSSLG 221
              |....:.:|.|.||.  .|.:....:.::....::..:..|         ....:.|....|.
  Rat   248 --KSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRVATKEDFLSSDVLD 310

  Fly   222 SYLYDSDPALRTLQQQRVP---LWLTLPEERSS-----QRLVGDETTDALRWAQTMGDAAASGFD 278
            :::......|: :.::..|   :||   .|.||     ..|:.:.......|...:|.:|..|.:
  Rat   311 TFILSVQKILK-VTKEMTPGKKVWL---GETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQLGIE 371

  Fly   279 VIFKRM-------NLVD--FERPNFSLYVTALFKKVMGSRVFPARPLNAFAPSNKLYTHCANAV- 333
            |:.:::       :|||  || |....:::.||||::|.:|..:|.........::|.||.|..
  Rat   372 VVMRQVFFGAGNYHLVDENFE-PLPDYWLSLLFKKLVGPKVLMSRVKGPDRSKLRVYLHCTNVYH 435

  Fly   334 ----SGGLAFMVVNTEEQPTTITVKSTSSLSSSEIWQYVLT--GHD----QRVQLNNVRLHL--N 386
                .|.|...|:|...  .|..:|....:.|..:.:|:|.  |.|    :.||||...|.:  .
  Rat   436 PRYREGDLTLYVLNLHN--VTKHLKLPPPMFSRPVDKYLLKPFGSDGLLSKSVQLNGQTLKMVDE 498

  Fly   387 TTLRPLIKPIDPTKPL----QLITPSMAVSFWVLPDVNLEHC 424
            .||..|.:     |||    .|..|:.:..|:|:.:..:..|
  Rat   499 QTLPALTE-----KPLPAGSSLSVPAFSYGFFVIRNAKIAAC 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14309	NP_650718.2	None
Hpse	NP_072127.1	Heparan sulfate-binding. /evidence=ECO:0000250\|UniProtKB:Q9Y251	55..57
		Heparan sulfate-binding. /evidence=ECO:0000250\|UniProtKB:Q9Y251	151..155
		Glyco_hydro_79n	<177..363	CDD:281637	32/185 (17%)
		Heparan sulfate-binding. /evidence=ECO:0000250\|UniProtKB:Q9Y251	263..273		1/9 (11%)
		Required for heterodimerization with the heparanase 8 kDa subunit. /evidence=ECO:0000250\|UniProtKB:Q9Y251	281..410		27/133 (20%)
		Heparan sulfate-binding. /evidence=ECO:0000250\|UniProtKB:Q9Y251	341..343		0/1 (0%)
		Heparan sulfate-binding. /evidence=ECO:0000250\|UniProtKB:Q9Y251	382..384		0/1 (0%)
		Required for transferring proheparanase to the Golgi apparatus, secretion and subsequent enzyme activity and for enhancement of PKB/AKT1 phosphorylation. /evidence=ECO:0000250\|UniProtKB:Q9Y251	520..536		3/16 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346548
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46145
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940