Protein Alignment CG14309 and HPSE2

DIOPT Version :10

• Sequence 1: NP_650718.2
• Gene: CG14309 / 42212
• FlyBaseID: FBgn0038611
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_068600.4
• Gene: HPSE2 / 60495
• HGNCID: 18374
• Length: 592
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 119/566 - (21%)
• Similarity: 190/566 - (33%)
• Gaps: 191/566 - (33%)

  Fly    19 TLVQLHVN--RPYNDVNEKFVSFAVRPEDLYDA-LDGKNRKAVTNLANLLGDAHIKFVG---DFY 77
            ||:.|.|:  .|...|||.|:|..:.|..::|. ||..:.|.:..||..|..|.::|.|   ||.
Human    59 TLILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRTDFL 123

  Fly    78 FASNAPTRLRNPTK--------------------------------------------------- 91
            ...|    ||||.|
Human   124 QFQN----LRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREKAAQM 184

  Fly    92 ---IIWKGF-NRWSRAVNWTMIIPVPY--------------------APDDWDSMHTLKILNTS- 131
               ::.:.| |.:|..:.....:...|                    ..:.|:|...|.:|..|
Human   185 HLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSA 249

  Fly   132 ---YMVGITDCIWQLGTD------------FGTSRAKDYVQELRTLKLMTDTFKPYVDDWRLMGA 181
               |.:.     |:||.:            .|:...|||:|    ||.:....:.| ....|.|.
Human   250 SKKYNIS-----WELGNEPNNYRTMHGRAVNGSQLGKDYIQ----LKSLLQPIRIY-SRASLYGP 304

  Fly   182 DIS----------------AGSSADET---KRYVDMSKDLNTAFGWTQPANMLPKSSLGSYLYDS 227
            :|.                |||:.|..   ..|:|         |.........|:.|...|.|.
Human   305 NIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYID---------GRVVKVMDFLKTRLLDTLSDQ 360

  Fly   228 DPALRTLQQQRVP---LWL--TLPEERSSQRLVGDETTDALRWAQTMGDAAASGFDVIFKRM--- 284
            ...::.:.....|   :||  .:.........:.|.......|..|:|..|..|.||:.:..
Human   361 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFD 425

  Fly   285 ----NLVDFERPNFS----LYVTALFKKVMGSRVFPA---------RPLNAFAPSNKLYTHCA-- 330
                :|||   .||:    .:::.|:|:::|.:|...         ||........::|.||.
Human   426 HGYNHLVD---QNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNH 487

  Fly   331 ---NAVSGGLAFMVVNTEEQPTTITVKSTSSLSSSEIWQYVLTGHDQR------VQLNNVRLHL- 385
               |.|.|.:...::|.......|  |...:|....:.||:|..:.|.      ||||...|.:
Human   488 HNHNYVRGSITLFIINLHRSRKKI--KLAGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMV 550

  Fly   386 -NTTLRPLIKPIDPTKPLQ----LITPSMAVSFWVLPDVNLEHCQF 426
             :.|| |.:||    :||:    |:.|.:.:.|:|:.:||...|::
Human   551 DDGTL-PELKP----RPLRAGRTLVIPPVTMGFYVVKNVNALACRY 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14309	NP_650718.2	None
HPSE2	NP_068600.4	Glyco_hydro_79n	<208..408	CDD:461010	38/218 (17%)