DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14309 and Hpse

DIOPT Version :9

Sequence 1:	NP_650718.2	Gene:	CG14309 / 42212	FlyBaseID:	FBgn0038611	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_690016.1	Gene:	Hpse / 15442	MGIID:	1343124	Length:	535	Species:	Mus musculus

Alignment Length:	403	Identity:	90/403 - (22%)
Similarity:	149/403 - (36%)	Gaps:	96/403 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 DFYFASNAPTRLRNPTKIIW--------------KGFNRWSRAVNWTMIIPVPYAPDD-WDSMHT 124
            |..|..||  .||.| .:.|              ||:|     ::|.:    ...|:. |...|.
Mouse   175 DLIFGLNA--LLRTP-DLRWNSSNAQLLLDYCSSKGYN-----ISWEL----GNEPNSFWKKAHI 227

  Fly   125 LKILNTSYMVGITDCIWQLGTDFGTSRAKDYVQELRTLKLMTDTFKPYVDDWRLMGADIS--AGS 187
            |       :.|:     |||.||         .||..| |....|:    :.:|.|.||.  .|.
Mouse   228 L-------IDGL-----QLGEDF---------VELHKL-LQRSAFQ----NAKLYGPDIGQPRGK 266

  Fly   188 SADETKRYVDMSKDLNTAFGW---------TQPANMLPKSSLGSYLYDSDPALRTLQQ----QRV 239
            :....:.::....::..:..|         ....:.|....|.:::......|:..::    ::|
Mouse   267 TVKLLRSFLKAGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKV 331

  Fly   240 PLWLTLPEERSSQRLVGDETTDALRWAQTMGDAAASGFDVIFKRM-------NLVD--FERPNFS 295
            .|..|.........|:.:.......|...:|.:|..|.:|:.:::       :|||  || |...
Mouse   332 WLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFE-PLPD 395

  Fly   296 LYVTALFKKVMGSRVFPARPLNAFAPSNKLYTHCANAV-----SGGLAFMVVNTEEQPTTITVKS 355
            .:::.||||::|.||..:|.........::|.||.|..     .|.|...|:|...  .|..:|.
Mouse   396 YWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLHN--VTKHLKV 458

  Fly   356 TSSLSSSEIWQYVL--TGHD----QRVQLNNVRLHL--NTTLRPLI-KPIDPTKPLQLITPSMAV 411
            ...|....:..|:|  :|.|    :.||||...|.:  ..||..|. ||:.....|.|  |:.:.
Mouse   459 PPPLFRKPVDTYLLKPSGPDGLLSKSVQLNGQILKMVDEQTLPALTEKPLPAGSALSL--PAFSY 521

  Fly   412 SFWVLPDVNLEHC 424
            .|:|:.:..:..|
Mouse   522 GFFVIRNAKIAAC 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14309	NP_650718.2	None
Hpse	NP_690016.1	Heparan sulfate-binding. /evidence=ECO:0000250\|UniProtKB:Q9Y251	54..56
		Heparan sulfate-binding. /evidence=ECO:0000250\|UniProtKB:Q9Y251	150..154
		Glyco_hydro_79n	<163..362	CDD:281637	41/224 (18%)
		Heparan sulfate-binding. /evidence=ECO:0000250\|UniProtKB:Q9Y251	262..272		1/9 (11%)
		Required for heterodimerization with the heparanase 8 kDa subunit. /evidence=ECO:0000250\|UniProtKB:Q9Y251	280..409		24/129 (19%)
		Heparan sulfate-binding. /evidence=ECO:0000250\|UniProtKB:Q9Y251	340..342		0/1 (0%)
		Heparan sulfate-binding. /evidence=ECO:0000250\|UniProtKB:Q9Y251	381..383		0/1 (0%)
		Required for transferring proheparanase to the Golgi apparatus, secretion and subsequent enzyme activity and for enhancement of PKB/AKT1 phosphorylation. /evidence=ECO:0000250\|UniProtKB:Q9Y251	519..535		3/16 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843044
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46145
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940