Protein Alignment CG14309 and Hpse

DIOPT Version :10

• Sequence 1: NP_650718.2
• Gene: CG14309 / 42212
• FlyBaseID: FBgn0038611
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_690016.1
• Gene: Hpse / 15442
• MGIID: 1343124
• Length: 535
• Species: Mus musculus
• Alignment Length: 403
• Identity: 90/403 - (22%)
• Similarity: 149/403 - (36%)
• Gaps: 96/403 - (23%)

  Fly    75 DFYFASNAPTRLRNPTKIIW--------------KGFNRWSRAVNWTMIIPVPYAPDD-WDSMHT 124
            |..|..||  .||.| .:.|              ||:|     ::|.:    ...|:. |...|.
Mouse   175 DLIFGLNA--LLRTP-DLRWNSSNAQLLLDYCSSKGYN-----ISWEL----GNEPNSFWKKAHI 227

  Fly   125 LKILNTSYMVGITDCIWQLGTDFGTSRAKDYVQELRTLKLMTDTFKPYVDDWRLMGADIS--AGS 187
            |       :.|:     |||.||         .||..| |....|:    :.:|.|.||.  .|.
Mouse   228 L-------IDGL-----QLGEDF---------VELHKL-LQRSAFQ----NAKLYGPDIGQPRGK 266

  Fly   188 SADETKRYVDMSKDLNTAFGW---------TQPANMLPKSSLGSYLYDSDPALRTLQQ----QRV 239
            :....:.::....::..:..|         ....:.|....|.:::......|:..::    ::|
Mouse   267 TVKLLRSFLKAGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKV 331

  Fly   240 PLWLTLPEERSSQRLVGDETTDALRWAQTMGDAAASGFDVIFKRM-------NLVD--FERPNFS 295
            .|..|.........|:.:.......|...:|.:|..|.:|:.:::       :|||  || |...
Mouse   332 WLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFE-PLPD 395

  Fly   296 LYVTALFKKVMGSRVFPARPLNAFAPSNKLYTHCANAV-----SGGLAFMVVNTEEQPTTITVKS 355
            .:::.||||::|.||..:|.........::|.||.|..     .|.|...|:|...  .|..:|.
Mouse   396 YWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLHN--VTKHLKV 458

  Fly   356 TSSLSSSEIWQYVL--TGHD----QRVQLNNVRLHL--NTTLRPLI-KPIDPTKPLQLITPSMAV 411
            ...|....:..|:|  :|.|    :.||||...|.:  ..||..|. ||:.....|.|  |:.:.
Mouse   459 PPPLFRKPVDTYLLKPSGPDGLLSKSVQLNGQILKMVDEQTLPALTEKPLPAGSALSL--PAFSY 521

  Fly   412 SFWVLPDVNLEHC 424
            .|:|:.:..:..|
Mouse   522 GFFVIRNAKIAAC 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14309	NP_650718.2	None
Hpse	NP_690016.1	Glyco_hydro_79n	<163..362	CDD:461010	41/224 (18%)
		Required for heterodimerization with the heparanase 8 kDa subunit. /evidence=ECO:0000250|UniProtKB:Q9Y251	280..409		24/129 (19%)
		Required for transferring proheparanase to the Golgi apparatus, secretion and subsequent enzyme activity and for enhancement of PKB/AKT1 phosphorylation. /evidence=ECO:0000250|UniProtKB:Q9Y251	519..535		3/16 (19%)