DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7675 and WWOX

DIOPT Version :9

Sequence 1:	NP_001287390.1	Gene:	CG7675 / 42211	FlyBaseID:	FBgn0038610	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_057457.1	Gene:	WWOX / 51741	HGNCID:	12799	Length:	414	Species:	Homo sapiens

Alignment Length:	301	Identity:	109/301 - (36%)
Similarity:	160/301 - (53%)	Gaps:	17/301 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LRITAGRCFTETKMEGKTVIITGANSGIGKETAKDLAGRGARIIMACRNLETANAVKDEIVKETK 101
            :.|..||.||     ||.|::||||||||.||||..|..||.:|:||||:..|:.....|::|..
Human   114 MEILQGRDFT-----GKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWH 173

  Fly   102 NNKILVKKLDLGSQKSVREFAADIVKTEPKIDVLIHNAGMALAFRGQTSEDGVELTMATNHYGPF 166
            ..|:....|||...:||:.||.........:.||:.||. ..|.....::||:|.|...||.|.|
Human   174 KAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAA-TFALPWSLTKDGLETTFQVNHLGHF 237

  Fly   167 LLTHLLIDVLKKSAPARIVIVASELYRLSSVN-------LAKLNPI-GTFPAAYLYYVSKFANIY 223
            .|..||.|||.:|||||:::|:||.:|.:.:|       .::|:|. ..:.|...|..||..||.
Human   238 YLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNIL 302

  Fly   224 FARELAKRLEGTKVTVNFLHPG-MIDSGIWRNVPFPLNLPMMAITKGFFKTTKAGAQTTIYLATS 287
            |:.||.:||....||.|.:||| |:.|.|.|:  :.:...:..:.:.|.|:.:.||.||:|.|..
Human   303 FSNELHRRLSPRGVTSNAVHPGNMMYSNIHRS--WWVYTLLFTLARPFTKSMQQGAATTVYCAAV 365

  Fly   288 NEVANVSGKYFMDCKEATLNAAALDEEKGLKIWEESVKIVK 328
            .|:..:.|.||.:|.....:..|..||....:|..|.::::
Human   366 PELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQ 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7675	NP_001287390.1	PRK06196	52..327	CDD:235736	104/283 (37%)
CG7675	NP_001287390.1	retinol-DH_like_SDR_c_like	52..320	CDD:212492	102/276 (37%)
WWOX	NP_057457.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		WW	19..47	CDD:238122
		Nuclear localization signal. /evidence=ECO:0000250	50..55
		WW	60..90	CDD:238122
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	104/286 (36%)
		Interaction with MAPT. /evidence=ECO:0000250	125..414		103/285 (36%)
		Mediates targeting to the mitochondria. /evidence=ECO:0000250	209..273		27/64 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.710