DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7675 and wwox

DIOPT Version :9

Sequence 1:	NP_001287390.1	Gene:	CG7675 / 42211	FlyBaseID:	FBgn0038610	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_957207.1	Gene:	wwox / 393887	ZFINID:	ZDB-GENE-040426-858	Length:	412	Species:	Danio rerio

Alignment Length:	296	Identity:	104/296 - (35%)
Similarity:	163/296 - (55%)	Gaps:	12/296 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MEGKTVIITGANSGIGKETAKDLAGRGARIIMACRNLETANAVKDEIVKETKNNKILVKKLDLGS 114
            :..|.:|:||||||||.|||:..|..||.:|:||||...|:.....|:.|....::.|..|||.|
Zfish   119 LSDKVIIVTGANSGIGFETARSFALHGAHVILACRNQSRASKAASLIMGEWSKARVEVLPLDLAS 183

  Fly   115 QKSVREFAADIVKTEPKIDVLIHNAGMALAFRGQTSEDGVELTMATNHYGPFLLTHLLIDVLKKS 179
            .:|||:||.....|:..:.||:.||.:. :...:.:|||.|.|....|.|.|||..||.|||:.|
Zfish   184 LRSVRQFAELFKATKLPLHVLVCNAAVC-SQPWRLTEDGFESTFQICHLGHFLLVQLLQDVLRLS 247

  Fly   180 APARIVIVASELYRLS-------SVNLAKLN-PIGTFPAAYLYYVSKFANIYFARELAKRLEGTK 236
            ||||:|:|:||.:|.:       :::|..|: |...:.:...|..:|..|:.|:.||.:|:....
Zfish   248 APARVVVVSSESHRFTDLLDSCGNLDLDLLSPPQKNYWSLLAYNRAKLCNLLFSSELHRRMSPHG 312

  Fly   237 VTVNFLHPG-MIDSGIWRNVPFPLNLPMMAITKGFFKTTKAGAQTTIYLATSNEVANVSGKYFMD 300
            :..|.|||| |:.:.|.|:  :.|...:.::.:.|.|:.:.||.||:|.|.:.|:..:.|.||.:
Zfish   313 ICCNALHPGSMMFTSIHRS--WWLLTLLFSLARPFTKSMQQGAATTVYCAVAPELEGIGGMYFNN 375

  Fly   301 CKEATLNAAALDEEKGLKIWEESVKIVKLTPQDPKI 336
            |.....:..|.|....|.:||.|.::|:.....|::
Zfish   376 CFRCLPSPQAQDPAAALSLWELSERLVQERSTPPQV 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7675	NP_001287390.1	PRK06196	52..327	CDD:235736	102/283 (36%)
CG7675	NP_001287390.1	retinol-DH_like_SDR_c_like	52..320	CDD:212492	99/276 (36%)
wwox	NP_957207.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		WW	18..47	CDD:278809
		Nuclear localization signal. /evidence=ECO:0000250	50..55
		WW	59..88	CDD:278809
		PRK06196	108..402	CDD:235736	102/285 (36%)
		human_WWOX_like_SDR_c-like	121..404	CDD:187669	103/285 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810