DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7675 and Wwox

DIOPT Version :9

Sequence 1:	NP_001287390.1	Gene:	CG7675 / 42211	FlyBaseID:	FBgn0038610	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	XP_006255728.1	Gene:	Wwox / 292041	RGDID:	1309927	Length:	414	Species:	Rattus norvegicus

Alignment Length:	301	Identity:	112/301 - (37%)
Similarity:	163/301 - (54%)	Gaps:	17/301 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LRITAGRCFTETKMEGKTVIITGANSGIGKETAKDLAGRGARIIMACRNLETANAVKDEIVKETK 101
            :.|..||.||     ||.|::||||||||.||||..|..||.:|:||||:..|:.....|::|..
  Rat   114 MEILQGRDFT-----GKVVLVTGANSGIGFETAKSFALHGAHVILACRNMSRASEAVSRILEEWH 173

  Fly   102 NNKILVKKLDLGSQKSVREFAADIVKTEPKIDVLIHNAGMALAFRGQTSEDGVELTMATNHYGPF 166
            ..|:....|||...:||:.||.........:.:|:.||| ..|.....::||:|.|...||.|.|
  Rat   174 KAKVEAMTLDLAVLRSVQHFAEAFKAKNVPLHILVCNAG-TFALPWSLTKDGLETTFQVNHLGHF 237

  Fly   167 LLTHLLIDVLKKSAPARIVIVASELYRLSSVN-------LAKLN-PIGTFPAAYLYYVSKFANIY 223
            .|..||.|||.:|||||:::|:||.:|.:.:|       |::|: ....:.|...|..||..||.
  Rat   238 YLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSSGKLDLSRLSLSSSDYWAMLAYNRSKLCNIL 302

  Fly   224 FARELAKRLEGTKVTVNFLHPG-MIDSGIWRNVPFPLNLPMMAITKGFFKTTKAGAQTTIYLATS 287
            |:.||.:.|....||.|.|||| |:.|.|.|| .:...| :..:.:.|.|:.:.||.||:|.|.:
  Rat   303 FSNELHRLLSPRGVTSNALHPGNMMFSAIHRN-SWVYKL-LFTLARPFTKSMQQGAATTVYCAVA 365

  Fly   288 NEVANVSGKYFMDCKEATLNAAALDEEKGLKIWEESVKIVK 328
            .|:..:.|.||.:|.....:..|.:||....:||.|.::::
  Rat   366 PELEGLGGMYFNNCCRCLPSEEAQNEETARALWELSERLIQ 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7675	NP_001287390.1	PRK06196	52..327	CDD:235736	107/283 (38%)
CG7675	NP_001287390.1	retinol-DH_like_SDR_c_like	52..320	CDD:212492	104/276 (38%)
Wwox	XP_006255728.1	WW	18..47	CDD:395320
		WW	60..90	CDD:238122
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	107/286 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810