DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7675 and RDH13

DIOPT Version :9

Sequence 1:	NP_001287390.1	Gene:	CG7675 / 42211	FlyBaseID:	FBgn0038610	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001139443.1	Gene:	RDH13 / 112724	HGNCID:	19978	Length:	331	Species:	Homo sapiens

Alignment Length:	329	Identity:	125/329 - (37%)
Similarity:	190/329 - (57%)	Gaps:	26/329 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RDIFLMTSVAAIVATLMSIRFYLRITAGRCFTETKMEGKTVIITGANSGIGKETAKDLAGRGARI 79
            |.:..::::..:....:.::.|  :|.|.|.::..:.|||||:||||:||||:||.:||.||..|
Human     3 RYLLPLSALGTVAGAAVLLKDY--VTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNI 65

  Fly    80 IMACRNLETANAVKDEIVKETKNNKILVKKLDLGSQKSVREFAADIVKTEPKIDVLIHNAGMALA 144
            |:|||::|...|...:|..||.|:.:..:.|||.|.||:|||||.|::.|.::|:||:|||: :.
Human    66 ILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGV-MR 129

  Fly   145 FRGQTSEDGVELTMATNHYGPFLLTHLLIDVLKKSAPARIVIVASELYRLSSVNLAKLN-PIGTF 208
            ....|:|||.|:....||.|.||||:||:|.||.|||:||:.::|..:....::...|| ....:
Human   130 CPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKY 194

  Fly   209 PAAYLYYVSKFANIYFARELAKRLEGTKVTVNFLHPGMIDSGIWRNVPFPLNLPMMAITKGFFKT 273
            .....|..||.|.:.|.:||::||:|:.||||.||||:..:.:.|:.         .|....|.:
Human   195 NTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHT---------GIHGSTFSS 250

  Fly   274 TKAG-------------AQTTIYLATSNEVANVSGKYFMDCKEATLNAAALDEEKGLKIWEESVK 325
            |..|             ||.:.|||.:.|:|:||||||...|:......|.|||...::|.||.:
Human   251 TTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESAR 315

  Fly   326 IVKL 329
            :|.|
Human   316 LVGL 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7675	NP_001287390.1	PRK06196	52..327	CDD:235736	118/288 (41%)
CG7675	NP_001287390.1	retinol-DH_like_SDR_c_like	52..320	CDD:212492	115/281 (41%)
RDH13	NP_001139443.1	retinol-DH_like_SDR_c	38..313	CDD:212495	116/284 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53570
OrthoDB	1	1.010	-	-		D414554at33208
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730