DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gl and ZAP1

DIOPT Version :9

Sequence 1:	NP_001262708.1	Gene:	gl / 42210	FlyBaseID:	FBgn0004618	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_012479.1	Gene:	ZAP1 / 853390	SGDID:	S000003592	Length:	880	Species:	Saccharomyces cerevisiae

Alignment Length:	662	Identity:	152/662 - (22%)
Similarity:	231/662 - (34%)	Gaps:	171/662 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NTILDSLEDQEGGAMYISCDVSNGGPVEPETGYVPNNPLFGLALDSPQQECAASCVGCLSCQGST 76
            ||:.||..........|.||                     |..|:|             |..||
Yeast   268 NTVPDSFSQLMSHLSEIDCD---------------------LTCDTP-------------CTAST 298

  Fly    77 ALP-----ISSLTSSDFD------CGGCFDPTIGVGVGIGGGHIQISTTPP-----ASSGNGSSN 125
            :..     :....||:.|      |..|.:.|.....   ..|:.:.:.||     .||....:|
Yeast   299 SATSGHKFVQDHQSSNNDDVFHKYCKFCEESTDNQPC---SKHMHLESKPPQLPPKCSSLRKPTN 360

  Fly   126 NGAGGGSSGNHGYWSTDEMASTFPGLPPL-DIDPLPSLF--PF-------------SPCGASYNF 174
            ...|    .||.|  .:.:.:|...|..| |:..:.||:  ||             :.|..|...
Yeast   361 TLQG----TNHAY--HEHILNTDMDLKILEDLCNISSLYEVPFGKHINHHDHNNAGNGCDGSSTG 419

  Fly   175 AAGNPHQAASLSYT----VHPHQMLISPNSHNHGQMHSQHQQHQHQQSQVQ-ASHVGNSLLQSSG 234
            ...|.:|..:|..:    .:|...|...|::..|...:.||.|.|   ::| .||..|.
Yeast   420 NNENGNQTMNLLLSSINRCNPKNNLNGSNNNTAGATSTDHQHHHH---RIQFHSHKPNR------ 475

  Fly   235 GNNIGSNGSAGGVANAASC-------------YYETSAGTAAPPPPPAA---------------- 270
             |||.:|.........|..             .||.....:.||..|..
Yeast   476 -NNIVNNSGISAANTTADLTNNDLNDLISREYSYERFRNQSEPPSLPKVTHQNQKNRRSWPTKDL 539

  Fly   271 ----------AMYPSMSVNVSMNMTMHHGYGAGDAGGVPMQCSQMNWTPPSNSTSA--------A 317
                      ::..|:|..:....|::..:...:.....::|   .|.....|.|:        .
Yeast   540 ESTDFSSLEDSLPSSISPPIQTTSTINFNWCFKEEKNNDLKC---KWKECPESCSSLFDLQRHLL 601

  Fly   318 AAAAAVNVLYP--PLLS---------------PGHYPASATYSFTADFRAPAPTGLGALPPLTVG 365
            ....:.:..:|  ||..               ..|.......:|...|..|.    ..||.....
Yeast   602 KDHVSQDFKHPMEPLACNWEDCDFLGDDTCSIVNHINCQHGINFDIQFANPD----SFLPGSISK 662

  Fly   366 EK----ESPSPPANS-SLAGYYP--TGVGNQGYTPPHKSPTSYQAAALGLSLSAFEDEEDSNEDL 423
            ||    ..|:|..:. |.|...|  |...:....||.|.|........|.:.| |...::.|:.|
Yeast   663 EKHHLLHCPNPQTHEVSKADGAPDMTSANDVSNIPPIKQPEQVICQWDGCNKS-FSSAQELNDHL 726

  Fly   424 DGDEGSSGGEMKPNLCRLCGKTYARPSTLKTHLRTHSGERPYRCPDCNKSFSQAANLTAHVRTHT 488
            :....:.|......|...|.:|:.:...|..||:.||..:||:|..|.:.||....|..|.|||:
Yeast   727 EAVHLTRGKSEYQCLWHDCHRTFPQRQKLIRHLKVHSKYKPYKCKTCKRCFSSEETLVQHTRTHS 791

  Fly   489 GQKPFRCPICDRRFSQSSSVTTHMRTHSGERPYRCSSCKKSFSDSSTLTKHLRIHSGEKPYQCKL 553
            |:||::|.||:::|:.|||:..|:|||:||:|.:|..|.|.|::||.|:||::.|  :|.|:|..
Yeast   792 GEKPYKCHICNKKFAISSSLKIHIRTHTGEKPLQCKICGKRFNESSNLSKHIKTH--QKKYKCSD 854

  Fly   554 CLLRFSQSGNLN 565
            |...|...|.||
Yeast   855 CSKSFDDLGKLN 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gl	NP_001262708.1	C2H2 Zn finger	439..459	CDD:275368	5/19 (26%)
		zf-C2H2	439..459	CDD:278523	5/19 (26%)
		zf-H2C2_2	452..476	CDD:290200	10/23 (43%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		zf-H2C2_2	479..504	CDD:290200	12/24 (50%)
		zf-C2H2_8	492..570	CDD:292531	33/74 (45%)
		C2H2 Zn finger	495..515	CDD:275368	9/19 (47%)
		zf-H2C2_2	507..531	CDD:290200	11/23 (48%)
		C2H2 Zn finger	523..543	CDD:275368	9/19 (47%)
		zf-H2C2_2	536..560	CDD:290200	9/23 (39%)
		C2H2 Zn finger	551..571	CDD:275368	6/15 (40%)
ZAP1	NP_012479.1	COG5048	292..761	CDD:227381	95/508 (19%)
		C2H2 Zn finger	743..762	CDD:275368	5/18 (28%)
		SUF4-like	766..>814	CDD:411020	21/47 (45%)
		C2H2 Zn finger	770..795	CDD:411020	10/24 (42%)
		C2H2 Zn finger	770..790	CDD:275368	7/19 (37%)
		C2H2 Zn finger	798..818	CDD:275368	9/19 (47%)
		zf-H2C2_2	810..834	CDD:404364	11/23 (48%)
		C2H2 Zn finger	826..846	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2374
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030