DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gl and VEZF1

DIOPT Version :9

Sequence 1:	NP_001262708.1	Gene:	gl / 42210	FlyBaseID:	FBgn0004618	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_005257700.1	Gene:	VEZF1 / 7716	HGNCID:	12949	Length:	527	Species:	Homo sapiens

Alignment Length:	352	Identity:	81/352 - (23%)
Similarity:	132/352 - (37%)	Gaps:	93/352 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 QMNWTP---PSNSTSAAAAAAAVNVLYPPLLSPGHYPASATYSFTADFRAPAPTGLGALPPLTVG 365
            :.|||.   .::..|.....||.|.|.|.|.|                 |..|.....|.|:.:.
Human     2 EANWTAFLFQAHEASHHQQQAAQNSLLPLLSS-----------------AVEPPDQKPLLPIPIT 49

  Fly   366 EKESPSP-------------PANSSLAGYYP----------------TGVGNQGYTPPHKSPT-- 399
            :|...:|             |..|.:..|..                ||:  :..:.|.|:||
Human    50 QKPQGAPETLKDAIGIKKEKPKTSFVCTYCSKAFRDSYHLRRHESCHTGI--KLVSRPKKTPTTV 112

  Fly   400 ----------SYQAAALGLSLSAFEDEEDSNEDLDGDEGSSGGEM--------------KPNLCR 440
                      |.:.:.:............|:...:....:|...|              |.:.|.
Human   113 VPLISTIAGDSSRTSLVSTIAGILSTVTTSSSGTNPSSSASTTAMPVTQSVKKPSKPVKKNHACE 177

  Fly   441 LCGKTYARPSTLKTHLRTHSGERPYRCPDCNKSFSQAANLTAHVRTHTG--QKPFRCPICDRRFS 503
            :|||.:.....|..|..:||.|:|:.||.||:.|.:...:|.|||:|.|  .||:.|.:|.:.||
Human   178 MCGKAFRDVYHLNRHKLSHSDEKPFECPICNQRFKRKDRMTYHVRSHEGGITKPYTCSVCGKGFS 242

  Fly   504 QSSSVTTHMR-THSGERPYRC------SSCKKSFSDSSTLTKHLRIHSGEKPYQCKLC--LLRFS 559
            :...::.|:: .||.|||::|      .:|..:|:....|..|:..|.|:  ..|.:|  ||
Human   243 RPDHLSCHVKHVHSTERPFKCQFSSLMQTCTAAFATKDRLRTHMVRHEGK--VSCNICGKLL--- 302

  Fly   560 QSGNLNRHMRVHGNNNSSNGSNGATGV 586
            .:..:..|::.||.:.|.|.:....|:
Human   303 SAAYITSHLKTHGQSQSINCNTCKQGI 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gl	NP_001262708.1	C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		zf-C2H2	439..459	CDD:278523	6/19 (32%)
		zf-H2C2_2	452..476	CDD:290200	11/23 (48%)
		C2H2 Zn finger	467..487	CDD:275368	9/19 (47%)
		zf-H2C2_2	479..504	CDD:290200	11/26 (42%)
		zf-C2H2_8	492..570	CDD:292531	23/86 (27%)
		C2H2 Zn finger	495..515	CDD:275368	5/20 (25%)
		zf-H2C2_2	507..531	CDD:290200	8/30 (27%)
		C2H2 Zn finger	523..543	CDD:275368	5/25 (20%)
		zf-H2C2_2	536..560	CDD:290200	8/25 (32%)
		C2H2 Zn finger	551..571	CDD:275368	5/21 (24%)
VEZF1	XP_005257700.1	C2H2 Zn finger	76..96	CDD:275368	1/19 (5%)
		C2H2 Zn finger	176..196	CDD:275368	6/19 (32%)
		zf-H2C2_2	188..213	CDD:290200	11/24 (46%)
		C2H2 Zn finger	204..224	CDD:275368	9/19 (47%)
		C2H2 Zn finger	234..252	CDD:275368	5/17 (29%)
		C2H2 Zn finger	263..289	CDD:275368	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3992
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860