DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gl and MYNN

DIOPT Version :9

Sequence 1:	NP_001262708.1	Gene:	gl / 42210	FlyBaseID:	FBgn0004618	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001172047.1	Gene:	MYNN / 55892	HGNCID:	14955	Length:	610	Species:	Homo sapiens

Alignment Length:	414	Identity:	117/414 - (28%)
Similarity:	172/414 - (41%)	Gaps:	137/414 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 QASHVGNSLLQSSGGNNIGSNGSAGGVANAASCYYETSAGTAAPPPPPA----AAMYPS-MSVNV 280
            :.|.|...|:|        :|...|.:|..:|   :|.....|...|..    ...||| :..|.
Human   154 EKSEVSTDLIQ--------ANPKQGALAKKSS---QTKKKKKAFNSPKTGQNKTVQYPSDILENA 207

  Fly   281 SMNMTMHHGYGAGDAGGVPM----QCSQMNWTPPSNSTSAAAAAAAVNVLYPPLLSPGHYPASAT 341
            |:.:.:       ||..:|.    |.:|:|.......||..               ...:||.
Human   208 SVELFL-------DANKLPTPVVEQVAQINDNSELELTSVV---------------ENTFPAQ-- 248

  Fly   342 YSFTADFRAPAPTGLGALPPLTVGEKESPSPPANSSLAGYYPTGVGNQGYTPPHKSPTSYQAAAL 406
                           ..:..:||..|...|.| |.:|..:..:.:.:.      |||  |:|
Human   249 ---------------DIVHTVTVKRKRGKSQP-NCALKEHSMSNIASV------KSP--YEA--- 286

  Fly   407 GLSLSAFEDEEDSNEDLDG----------------DEGSS---------GGEMKPNLCRLCGKTY 446
                      |:|.|:||.                .|.||         |  :||.:|.||||.:
Human   287 ----------ENSGEELDQRYSKAKPMCNTCGKVFSEASSLRRHMRIHKG--VKPYVCHLCGKAF 339

  Fly   447 ARPSTLKTHLRTHSGERPYRCPDCNKSFSQ-----------------------------AANLTA 482
            .:.:.||||:|||:||:||:|..|:|.|:|                             ::||..
Human   340 TQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKI 404

  Fly   483 HVRTHTGQKPFRCPICDRRFSQSSSVTTHMRTHSGERPYRCSSCKKSFSDSSTLTKHLRIHSGEK 547
            |.|.|:|:||:.|..|.:||:|:|::|.|:|.|:||:||.|.:|.|:|:.||:|..|.|.|:|||
Human   405 HARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEK 469

  Fly   548 PYQCKLCLLRFSQSGNLNRHMRVH 571
            ||.|.:|...|..||.||:|.|.|
Human   470 PYICGICGKSFISSGELNKHFRSH 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gl	NP_001262708.1	C2H2 Zn finger	439..459	CDD:275368	10/19 (53%)
		zf-C2H2	439..459	CDD:278523	10/19 (53%)
		zf-H2C2_2	452..476	CDD:290200	15/23 (65%)
		C2H2 Zn finger	467..487	CDD:275368	9/48 (19%)
		zf-H2C2_2	479..504	CDD:290200	12/24 (50%)
		zf-C2H2_8	492..570	CDD:292531	38/77 (49%)
		C2H2 Zn finger	495..515	CDD:275368	9/19 (47%)
		zf-H2C2_2	507..531	CDD:290200	11/23 (48%)
		C2H2 Zn finger	523..543	CDD:275368	9/19 (47%)
		zf-H2C2_2	536..560	CDD:290200	12/23 (52%)
		C2H2 Zn finger	551..571	CDD:275368	9/19 (47%)
MYNN	NP_001172047.1	BTB	14..115	CDD:306997
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..197		6/30 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	174..190		3/18 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	257..262		1/4 (25%)
		C2H2 Zn finger	304..324	CDD:275368	3/19 (16%)
		zf-C2H2	304..324	CDD:306579	3/19 (16%)
		zf-H2C2_2	316..341	CDD:316026	9/26 (35%)
		C2H2 Zn finger	332..352	CDD:275368	10/19 (53%)
		zf-H2C2_2	345..369	CDD:316026	15/23 (65%)
		SFP1	<354..438	CDD:227516	26/83 (31%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		C2H2 Zn finger	389..409	CDD:275368	4/19 (21%)
		C2H2 Zn finger	417..437	CDD:275368	9/19 (47%)
		zf-H2C2_2	430..453	CDD:316026	11/22 (50%)
		SFP1	<439..522	CDD:227516	29/55 (53%)
		C2H2 Zn finger	445..465	CDD:275368	9/19 (47%)
		C2H2 Zn finger	473..493	CDD:275368	9/19 (47%)
		C2H2 Zn finger	501..522	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..556
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910