DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gl and Aef1

DIOPT Version :9

Sequence 1:	NP_001262708.1	Gene:	gl / 42210	FlyBaseID:	FBgn0004618	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001262157.1	Gene:	Aef1 / 40370	FlyBaseID:	FBgn0005694	Length:	454	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	113/460 - (24%)
Similarity:	171/460 - (37%)	Gaps:	170/460 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 QMLISPNSHNHGQMHSQH-------QQHQHQQSQVQASHVGNSLLQSSGGNNIGSNGSAGGVANA 250
            |..|:.|::|.....:.|       ||.|.||.|.|..|......||||..::
  Fly    31 QTTIANNNNNETVTQATHPAHMAAVQQQQQQQQQQQQQHHQQQQQQSSGPPSV------------ 83

  Fly   251 ASCYYETSAGTAAPPPPPAAAMYPSMSVNVSMNMTMHHGYGAGDAGGVPMQCSQMNWTPPSNSTS 315
                          ||||.....|         ..||       ..|:..:         ::|.:
  Fly    84 --------------PPPPTELPLP---------FQMH-------LSGISAE---------AHSAA 109

  Fly   316 AAAAAAAVNVLYPPLLSPGHYPASATYSFTADFRAPAPTGLGALPPLTVGEKESPSPPAN--SSL 378
            .|||.||..             |:|..:..|                   |::.|.||.:  :.|
  Fly   110 QAAAMAAAQ-------------AAAAQAAAA-------------------EQQQPPPPTSHLTHL 142

  Fly   379 AGYYPTGVGNQGY-TPPHKSPTSYQAAALGLSLSAFEDEEDSNEDLDGDEGSSGGEMKPNLCRLC 442
            ..:.||.:.::.| ...|........||:|:                      ||.::
  Fly   143 TTHSPTTIHSEHYLANGHSEHPGEGNAAVGV----------------------GGAVR------- 178

  Fly   443 GKTYARPSTLKTHLRTHSGERPYRCPDCNKSFSQAANLTAHVRTHTGQKPFRCPICDRRFSQSSS 507
                             ..|:|:.|..|::.|.|.:.||.||:.|||:||::|.:||:.|.|||:
  Fly   179 -----------------EPEKPFHCTVCDRRFRQLSTLTNHVKIHTGEKPYKCNVCDKTFRQSST 226

  Fly   508 VTTHMRTHSGERPYRCSSCKKSFSDSSTLTKHLRIHSGEKPYQCKLCLLRFSQSGNLNRHMRVHG 572
            :|.|::.|:||:||.|:.|.|.|...|||..|::||:||||::|.:|..:|.||..||.|:::|.
  Fly   227 LTNHLKIHTGEKPYNCNFCPKHFRQLSTLANHVKIHTGEKPFECVICKKQFRQSSTLNNHIKIHV 291

  Fly   573 NNN-------SSNGSNGATGVGGESSTGSGVGGGNSLLTXQKPRSAGGFQHYHPPHTHHMHHQHH 630
            .:.       .:....| .|                    :.|.:|    |:|....|..|||..
  Fly   292 MDKVYVPVKIKTEEDEGXLG--------------------RMPLAA----HHHQQQQHQHHHQQQ 332

  Fly   631 AHHHH 635
            .|.||
  Fly   333 QHQHH 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gl	NP_001262708.1	C2H2 Zn finger	439..459	CDD:275368	0/19 (0%)
		zf-C2H2	439..459	CDD:278523	0/19 (0%)
		zf-H2C2_2	452..476	CDD:290200	5/23 (22%)
		C2H2 Zn finger	467..487	CDD:275368	8/19 (42%)
		zf-H2C2_2	479..504	CDD:290200	13/24 (54%)
		zf-C2H2_8	492..570	CDD:292531	37/77 (48%)
		C2H2 Zn finger	495..515	CDD:275368	9/19 (47%)
		zf-H2C2_2	507..531	CDD:290200	10/23 (43%)
		C2H2 Zn finger	523..543	CDD:275368	8/19 (42%)
		zf-H2C2_2	536..560	CDD:290200	11/23 (48%)
		C2H2 Zn finger	551..571	CDD:275368	8/19 (42%)
Aef1	NP_001262157.1	C2H2 Zn finger	186..206	CDD:275368	8/19 (42%)
		zf-H2C2_2	199..223	CDD:290200	13/23 (57%)
		C2H2 Zn finger	214..234	CDD:275368	9/19 (47%)
		zf-H2C2_2	227..251	CDD:290200	11/23 (48%)
		C2H2 Zn finger	242..262	CDD:275368	8/19 (42%)
		zf-H2C2_2	255..279	CDD:290200	11/23 (48%)
		C2H2 Zn finger	270..290	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BIHU
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810