DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gl and ZNF829

DIOPT Version :9

Sequence 1:	NP_001262708.1	Gene:	gl / 42210	FlyBaseID:	FBgn0004618	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001165450.1	Gene:	ZNF829 / 374899	HGNCID:	34032	Length:	513	Species:	Homo sapiens

Alignment Length:	177	Identity:	69/177 - (38%)
Similarity:	100/177 - (56%)	Gaps:	8/177 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 HKSPTSYQAAALGLSLSAFEDEEDSNEDLDGDEGSSGGEMKPNLCRLCGKTYARPSTLKTHLRTH 459
            |.....|:....|.:.....:..|......|:        ||..|::|||.:.:.|.|..|||.|
Human   315 HTGEKPYECKECGKAFKYCSNLNDHQRIHTGE--------KPYECKVCGKAFTKSSQLFLHLRIH 371

  Fly   460 SGERPYRCPDCNKSFSQAANLTAHVRTHTGQKPFRCPICDRRFSQSSSVTTHMRTHSGERPYRCS 524
            :||:||.|.:|.|:|:|.:.|..|.|.|||:||:.|..|.:.|:.:|::|.|.|.|:||:.|.|.
Human   372 TGEKPYECKECGKAFTQHSRLIQHQRMHTGEKPYECKQCGKAFNSASTLTNHHRIHAGEKLYECE 436

  Fly   525 SCKKSFSDSSTLTKHLRIHSGEKPYQCKLCLLRFSQSGNLNRHMRVH 571
            .|:|:|..||.|.:|.|||:.||||:|..|...|::..||.||.|:|
Human   437 ECRKAFIQSSELIQHQRIHTDEKPYECNECGKAFNKGSNLTRHQRIH 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gl	NP_001262708.1	C2H2 Zn finger	439..459	CDD:275368	9/19 (47%)
		zf-C2H2	439..459	CDD:278523	9/19 (47%)
		zf-H2C2_2	452..476	CDD:290200	13/23 (57%)
		C2H2 Zn finger	467..487	CDD:275368	8/19 (42%)
		zf-H2C2_2	479..504	CDD:290200	11/24 (46%)
		zf-C2H2_8	492..570	CDD:292531	34/77 (44%)
		C2H2 Zn finger	495..515	CDD:275368	7/19 (37%)
		zf-H2C2_2	507..531	CDD:290200	10/23 (43%)
		C2H2 Zn finger	523..543	CDD:275368	9/19 (47%)
		zf-H2C2_2	536..560	CDD:290200	12/23 (52%)
		C2H2 Zn finger	551..571	CDD:275368	8/19 (42%)
ZNF829	NP_001165450.1	KRAB	116..176	CDD:214630
		KRAB	116..155	CDD:279668
		COG5048	<149..425	CDD:227381	40/117 (34%)
		zf-C2H2	238..259	CDD:278523
		C2H2 Zn finger	239..259	CDD:275368
		C2H2 Zn finger	271..287	CDD:275368
		zf-H2C2_2	282..304	CDD:290200
		C2H2 Zn finger	295..315	CDD:275368	69/177 (39%)
		zf-H2C2_2	307..332	CDD:290200	3/16 (19%)
		C2H2 Zn finger	323..343	CDD:275368	2/19 (11%)
		zf-H2C2_2	335..359	CDD:290200	8/31 (26%)
		C2H2 Zn finger	351..371	CDD:275368	9/19 (47%)
		zf-H2C2_2	367..388	CDD:290200	12/20 (60%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		zf-H2C2_2	392..416	CDD:290200	11/23 (48%)
		C2H2 Zn finger	407..427	CDD:275368	7/19 (37%)
		C2H2 Zn finger	435..455	CDD:275368	9/19 (47%)
		zf-H2C2_2	447..471	CDD:290200	11/23 (48%)
		C2H2 Zn finger	463..483	CDD:275368	8/19 (42%)
		zf-H2C2_2	475..498	CDD:290200	6/9 (67%)
		C2H2 Zn finger	491..511	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910