DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gl and crol

DIOPT Version :9

Sequence 1:	NP_001262708.1	Gene:	gl / 42210	FlyBaseID:	FBgn0004618	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster

Alignment Length:	654	Identity:	134/654 - (20%)
Similarity:	214/654 - (32%)	Gaps:	225/654 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DVSNGGPVEPETGYVPNNPLFGLALDSPQQECAASCVGCLSCQGSTALPISS-----LTSSDFDC 90
            ||.|........|.:|..|.....:.|.....||:.....:...:.|..::|     ..::....
  Fly    74 DVVNHQLAAAHGGQLPPPPPLPPQVTSHAASAAAAAAAASTNNAAVAAVMASANAAAAAAAAASA 138

  Fly    91 GGCFDPTIGVGVGIGGGHIQISTTPPASSGNGSSNNG-----AG--------GG-----SSGNHG 137
            ||...|...   |.||..:.::||..::|..||:.:|     ||        ||     .|||.|
  Fly   139 GGGLPPATS---GNGGQQVTVTTTSSSTSSGGSTTSGGTTTTAGELLMPKMEGGIHGVDGSGNGG 200

  Fly   138 YWSTDEMASTFPGLP------PLDIDPLPSLFPFSPCGASYNFAAGNPHQAASLSYTVHPHQMLI 196
            ......:|....|.|      ..||           ||..:.|.                :|:::
  Fly   201 NGGGQNVALAPDGTPIATGTHVCDI-----------CGKMFQFR----------------YQLIV 238

  Fly   197 SPNSHN----------------------HGQMH---------------------SQHQQHQH--- 215
            ....|:                      ||::|                     .:|.:...
  Fly   239 HRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDK 303

  Fly   216 -------QQSQVQASHVGNSLLQSSGGNNIGSNGSAGGVANAASCYYETSAGTAAPPPPPAAAMY 273
                   |::..:..|:.|.....:|                     ||          |....|
  Fly   304 PFACTICQKTFARKEHLDNHFRSHTG---------------------ET----------PFRCQY 337

  Fly   274 PSMSVNVSMNMTMH---HGYGAGDAGGVPMQCSQMNWTPPSNSTSAAAAAAAVNVLYPPLLSPGH 335
            .:.:.....:|..|   |      .|..|.:|                     ::.........|
  Fly   338 CAKTFTRKEHMVNHVRKH------TGETPHRC---------------------DICKKSFTRKEH 375

  Fly   336 YPASATYSFTADFRAPAPTGLGALPPLTVGEKESPSPPANSSLAG-YYPTGVGNQGYTPPHKSPT 399
            |.....:.          ||               ..|....:.| .|........:...|.:.|
  Fly   376 YVNHYMWH----------TG---------------QTPHQCDVCGKKYTRKEHLANHMRSHTNET 415

  Fly   400 SYQAAALGLSLSAFEDEEDSN-----------------------EDLDGDEGSSGGEMKPNLCRL 441
            .::....|.|.|  ..|..:|                       |.|........|| .|:.|..
  Fly   416 PFRCEICGKSFS--RKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGE-SPHRCSY 477

  Fly   442 CGKTYARPSTLKTHLRTHSGERPYRCPDCNKSFSQAANLTAHVRTHTGQKPFRCPICDRRFSQSS 506
            |.||:.|...|..|:|.|:||.|::|..|.|:|::..::..|||.|||:.|.:|..|.:.|::..
  Fly   478 CMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKE 542

  Fly   507 SVTTHMRTHSGERPYRCSSCKKSFSDSSTLTKHLRIHSGEKPYQCKLCLLRFSQSGNLNRHMRVH 571
            .:|.|:|.|:|:.|:|||.|||:|:....||.|:|:|:|:.|::|:.|...|::..:||.|||.|
  Fly   543 HLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQH 607

  Fly   572 GNNN 575
            .::|
  Fly   608 SSDN 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gl	NP_001262708.1	C2H2 Zn finger	439..459	CDD:275368	8/19 (42%)
		zf-C2H2	439..459	CDD:278523	8/19 (42%)
		zf-H2C2_2	452..476	CDD:290200	11/23 (48%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		zf-H2C2_2	479..504	CDD:290200	10/24 (42%)
		zf-C2H2_8	492..570	CDD:292531	31/77 (40%)
		C2H2 Zn finger	495..515	CDD:275368	6/19 (32%)
		zf-H2C2_2	507..531	CDD:290200	12/23 (52%)
		C2H2 Zn finger	523..543	CDD:275368	10/19 (53%)
		zf-H2C2_2	536..560	CDD:290200	10/23 (43%)
		C2H2 Zn finger	551..571	CDD:275368	8/19 (42%)
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	6/46 (13%)
		C2H2 Zn finger	251..271	CDD:275368	2/19 (11%)
		C2H2 Zn finger	279..299	CDD:275368	1/19 (5%)
		COG5048	300..723	CDD:227381	89/398 (22%)
		C2H2 Zn finger	307..327	CDD:275368	3/19 (16%)
		C2H2 Zn finger	335..355	CDD:275368	3/19 (16%)
		C2H2 Zn finger	363..383	CDD:275368	3/40 (8%)
		C2H2 Zn finger	391..411	CDD:275368	2/19 (11%)
		C2H2 Zn finger	419..439	CDD:275368	5/21 (24%)
		C2H2 Zn finger	447..467	CDD:275368	2/19 (11%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	10/19 (53%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010