DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gl and Zfp648

DIOPT Version :9

Sequence 1:	NP_001262708.1	Gene:	gl / 42210	FlyBaseID:	FBgn0004618	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001191837.1	Gene:	Zfp648 / 100503355	MGIID:	2685049	Length:	525	Species:	Mus musculus

Alignment Length:	501	Identity:	125/501 - (24%)
Similarity:	182/501 - (36%)	Gaps:	166/501 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 GSNGSAGGVANAASCYYET-------------SAGTAAPPPPPAAAMYPSMSVNVSMNMTMHHGY 290
            |..|.:.|..|.....::|             |||..|..|    ...|..:.|
Mouse    32 GRKGGSPGTQNNTDSQFDTQSCKEEENWPECFSAGCVAQKP----GEMPGKTSN----------- 81

  Fly   291 GAGDAGGVPMQCSQMNWTPPSNSTSAAAAAAAVNVLYPPLLSPGHYPASATYSFTADFRAPAPTG 355
                 ||  .:.|::.....|.....|..|.:.::|:...:.|      ...|..:|
Mouse    82 -----GG--KKASRITQIRDSPKLQEALGAPSRSLLHKVQIQP------LRDSVGSD-------- 125

  Fly   356 LGALPPLTVGEKESPSPPANSSLAGYYPTGVGNQGYTPPHKSPTSYQAAALGL-SLSAFEDEED- 418
                     |.|::...||:.....:..:|    ||   .::..|.:|::|.. ||..|...|.
Mouse   126 ---------GGKKANKDPASEVPNSFLDSG----GY---FEAQNSVEASSLDKNSLEHFPRSEST 174

  Fly   419 ----------------SNEDLDGDEGSSGGEM---------------------------KPNLCR 440
                            |:..:.|..|..|...                           ||.:|:
Mouse   175 LVQTPTIPASLLVKVRSSRKVQGQAGPEGSGQEEEGLDRCVRAFQKSTKVQVPAEHHGSKPYVCQ 239

  Fly   441 LCGKTYARPSTLKTHLRTHSGERPYRCPDCNKSFSQAANLTAHVRTHTGQKPFRCPICDRRFSQS 505
            ||||.|:..|||:.|.|.|:||||||||.|:|:::.:::...|:|||||:||:.||.|.|.|.:|
Mouse   240 LCGKAYSHRSTLQQHRRLHTGERPYRCPFCDKAYTWSSDHRKHIRTHTGEKPYGCPDCGRAFVRS 304

  Fly   506 S-----------------------------SVTTHMRTHSGERPYRCSSCKKSFSDSSTLTKHLR 541
            |                             |:..|.|||.|.:|:|||||.:.||.:|.:.:|.|
Mouse   305 SDLRKHQRNMHSNDKPFPCAQCGLTFNRPLSLLRHQRTHLGAKPFRCSSCGREFSVASRMVEHQR 369

  Fly   542 IHSGEKPYQCKLCLLRFSQSGNLNRHMRVHGNNNSSNGSNGATGVGGESSTGSGVGGGNSLLTXQ 606
            :||||:|:.|..|...|::|.||..|..:|            ||......|..||       | .
Mouse   370 VHSGERPFPCSTCGKCFTKSSNLQEHQTLH------------TGQRPFKCTDCGV-------TFA 415

  Fly   607 KPRSAGGFQHYHP---PHTHHMHHQHHAH-----HHHHAHMGNYDY 644
            :|......|..|.   |.......|..|.     .|...|.|:.|:
Mouse   416 QPSRLLRHQRIHTGERPFPCAECGQAFARSSTLKRHQQIHSGDKDF 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gl	NP_001262708.1	C2H2 Zn finger	439..459	CDD:275368	11/19 (58%)
		zf-C2H2	439..459	CDD:278523	11/19 (58%)
		zf-H2C2_2	452..476	CDD:290200	14/23 (61%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		zf-H2C2_2	479..504	CDD:290200	13/24 (54%)
		zf-C2H2_8	492..570	CDD:292531	37/106 (35%)
		C2H2 Zn finger	495..515	CDD:275368	10/48 (21%)
		zf-H2C2_2	507..531	CDD:290200	12/23 (52%)
		C2H2 Zn finger	523..543	CDD:275368	9/19 (47%)
		zf-H2C2_2	536..560	CDD:290200	10/23 (43%)
		C2H2 Zn finger	551..571	CDD:275368	7/19 (37%)
Zfp648	NP_001191837.1	C2H2 Zn finger	238..258	CDD:275368	11/19 (58%)
		zf-H2C2_2	251..274	CDD:290200	14/22 (64%)
		COG5048	262..>508	CDD:227381	69/219 (32%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		zf-H2C2_2	280..303	CDD:290200	13/22 (59%)
		C2H2 Zn finger	294..312	CDD:275368	7/17 (41%)
		C2H2 Zn finger	323..343	CDD:275368	3/19 (16%)
		zf-H2C2_2	335..359	CDD:290200	12/23 (52%)
		C2H2 Zn finger	351..371	CDD:275368	9/19 (47%)
		zf-H2C2_2	366..387	CDD:290200	9/20 (45%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	10/43 (23%)
		C2H2 Zn finger	407..427	CDD:275368	6/26 (23%)
		zf-H2C2_2	420..444	CDD:290200	4/23 (17%)
		C2H2 Zn finger	435..455	CDD:275368	3/19 (16%)
		zf-H2C2_2	448..470	CDD:290200	4/14 (29%)
		C2H2 Zn finger	463..483	CDD:275368
		zf-H2C2_2	475..500	CDD:290200
		zf-C2H2	489..511	CDD:278523
		C2H2 Zn finger	491..511	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910