Protein Alignment MEN1 and men1

DIOPT Version :10

• Sequence 1: NP_001394079.1
• Gene: MEN1 / 4221
• HGNCID: 7010
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_571028.1
• Gene: men1 / 30130
• ZFINID: ZDB-GENE-991110-12
• Length: 617
• Species: Danio rerio
• Alignment Length: 671
• Identity: 414/671 - (61%)
• Similarity: 489/671 - (72%)
• Gaps: 68/671 - (10%)

Human     1 MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQP 65
            ||:::.||..||||.||.||:||.:||...||||.||||||||||||||||||:|.|||.:.|:|
Zfish     1 MGIRSTQKKHFPLRGIDGVVQLFESELNSPEPDLALLSLVLGFVEHFLAVNRVVPVNVPGVRFEP 65

Human    66 SPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLS 130
            .   .|....:.||..:|::::|||.||.||||||||:|.|.:..|.||||||||||||||||||
Zfish    66 L---QPDSLNSCFPTVELNLLSALYERFMAQIRGAVDMSQYRKPSGASSRELVKKVSDVIWNSLS 127

Human   131 RSYFKDRAHIQSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNG 195
            |||||||||||||||.||     ||||||||||||||.|||.|||:|||||||||||||:||..|
Zfish   128 RSYFKDRAHIQSLFSLIT-----GTKLDSSGVAFAVVAACQVLGLKDVHLALSEDHAWVIFGKGG 187

Human   196 EQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLE 260
            |:|||||||||||||||||||:||:.||||||||||||:|:|.|||||||||||||:||||||.|
Zfish   188 EETAEVTWHGKGNEDRRGQTVSAGINERSWLYLKGSYMKCNRNMEVAFMVCAINPSLDLHTDSTE 252

Human   261 LLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYP 325
            |:||||:|||||||.|.|||||||:|.|||||:.||..|:..||:::.|.:.|||.||.:|||||
Zfish   253 LIQLQQRLLWLLYDRGDLERYPMAMGTLADLEDQEPMTGKESPLSIHLKAVESAKKYYNNEHIYP 317

Human   326 YMYLAGYHCRNRNVREALQAWADTATVIQETVSNLQCLTTIIQQWDFHPRPHAPLLILAFFLWAD 390
            ||||||||.|:|.|||||.:||:.|:|:|:
Zfish   318 YMYLAGYHYRHREVREALGSWAEAASVMQD----------------------------------- 347

Human   391 PDSIILHYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEA-GEERPGEQSQGTQSQG-SALQD 453
                   |||||||||||||||::||||||.||||.|:..|: |.:...::.|..::.. :||||
Zfish   348 -------YNYCREDEEIYKEFFDIANDVIPTLLKETAAAAESEGTDEAEKEDQPREAAALTALQD 405

Human   454 PECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPW 518
            ||||||||||||||||||||||||||||||||:|||||.||:.|:||||.|::::.|..:.::..
Zfish   406 PECFAHLLRFYDGICKWEEGSPTPVLHVGWATYLVQSLSRFDAQIRQKVSIITKDTEPVDDDDQS 470

Human   519 GEEAREGRRRGPRRESKPEEP-----PPPKKPA-----LDKGLGTGQGAVSGPPRKPPGTVAGTA 573
            .|:.|||||||||||||.:||     |.|..||     :.|.:| |:|   |..|....|....|
Zfish   471 SEDLREGRRRGPRRESKLDEPAGSASPNPALPAQNQNPVPKKVG-GEG---GRRRSSASTRGKEA 531

Human   574 RGP-EGGSTAQVPAPTASPPPE-GPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKK 636
            .|. |..|.:.:|:|:..|..: |||:.|.|||||||||||.|.|:||||||||||||||||||:
Zfish   532 DGKNEPSSPSPIPSPSQPPAVQGGPVVVFHSEKMKGMKELLSAAKVNSSAIKLQLTAQSQVQMKR 596

Human   637 QKVSTPSDYTLSFLKRQRKGL 657
            ||.:...||||||:||.||.|
Zfish   597 QKPTASGDYTLSFMKRPRKTL 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEN1	NP_001394079.1	Menin	2..655	CDD:398642	410/666 (62%)
men1	NP_571028.1	Menin	2..615	CDD:398642	410/666 (62%)