Protein Alignment MEN1 and Men1

DIOPT Version :10

• Sequence 1: NP_001394079.1
• Gene: MEN1 / 4221
• HGNCID: 7010
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_001161960.1
• Gene: Men1 / 17283
• MGIID: 1316736
• Length: 617
• Species: Mus musculus
• Alignment Length: 658
• Identity: 588/658 - (89%)
• Similarity: 594/658 - (90%)
• Gaps: 48/658 - (7%)

Human     1 MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQP 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     7 MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQP 71

Human    66 SPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLS 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    72 SPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLS 136

Human   131 RSYFKDRAHIQSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNG 195
            ||||||||||||||||||     ||||||||||||||||||||||||||||||||||||||||||
Mouse   137 RSYFKDRAHIQSLFSFIT-----GTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNG 196

Human   196 EQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLE 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   197 EQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLE 261

Human   261 LLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYP 325
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
Mouse   262 LLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYQDEHIYP 326

Human   326 YMYLAGYHCRNRNVREALQAWADTATVIQETVSNLQCLTTIIQQWDFHPRPHAPLLILAFFLWAD 390
            |||||||||||||||||||||||||||||:
Mouse   327 YMYLAGYHCRNRNVREALQAWADTATVIQD----------------------------------- 356

Human   391 PDSIILHYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPE 455
                   ||||||||||||||||||||||||||||||||||.||||.|||:||||.|||||||||
Mouse   357 -------YNYCREDEEIYKEFFEVANDVIPNLLKEAASLLETGEERTGEQAQGTQGQGSALQDPE 414

Human   456 CFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGE 520
            |||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||:
Mouse   415 CFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVHIVSREAEAAEAEEPWGD 479

Human   521 EAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTAR-GPEGGSTAQV 584
            ||||||||||||||||||||||||||||||.|:||.|.||||||..|||.||.| |.|.|:.||.
Mouse   480 EAREGRRRGPRRESKPEEPPPPKKPALDKGPGSGQSAGSGPPRKTSGTVPGTTRGGQEVGNAAQA 544

Human   585 PAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSF 649
            |||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   545 PAPAASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSF 609

Human   650 LKRQRKGL 657
            ||||||||
Mouse   610 LKRQRKGL 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEN1	NP_001394079.1	Menin	2..655	CDD:398642	583/653 (89%)
Men1	NP_001161960.1	Menin	8..615	CDD:398642	583/653 (89%)