DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup43 and NEDD1

DIOPT Version :9

Sequence 1:	NP_650716.2	Gene:	Nup43 / 42209	FlyBaseID:	FBgn0038609	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_001119176.1	Gene:	NEDD1 / 830483	AraportID:	AT5G05970	Length:	782	Species:	Arabidopsis thaliana

Alignment Length:	276	Identity:	59/276 - (21%)
Similarity:	100/276 - (36%)	Gaps:	74/276 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VRLWRLQSNQYVTATDSEVDQIPRCMDKVR-MEDDVTAMEFVDKDT-LAVSCADGHLSVFNV--- 102
            |::|.||..              .|:.|:: ....:|.:.:..||. ||.....|.|.|.|:
plant   117 VKIWDLQRK--------------LCIKKLKGHTSTITGVMYNCKDEHLASVSVGGDLIVHNLASG 167

  Fly   103 HRAVE----EDQMQRT---SRSGRLHCFQRSQEPAPCTDLSVYGTDIATAGEDGCVSIVSVENVR 160
            .||.|    ..|:.|.   |||.| |.                   :.|||:||.|.:.......
plant   168 ARATELKDPNGQVLRLLDYSRSSR-HL-------------------LVTAGDDGTVHLWDTTGRS 212

  Fly   161 QVKRQIEADSMALFSICYISQQELVTANRMGVIRMLDARVAT--EAQPKTTFMVASQDDKSNFVS 223
            .....::..|.....:|:....|.:.|: :|    :|.::.|  ....:::..:|.:..    .|
plant   213 PKMSWLKQHSAPTAGVCFSPSNEKIIAS-VG----MDKKLYTYDSGSRRSSSCIAYEAP----FS 268

  Fly   224 SLAKHPMQQHILLCGSEEGSITVWDMRNLSYPASYLSA--HKSPINEIGFHQKDP----SKLFTA 282
            ||| .....:||:.|:..|.:..:|:|....|.:.|.|  :...:..:.:....|    .|.:|
plant   269 SLA-FGDNGYILVAGTSNGRVVFYDIRGKPQPVTVLHAFSNSEDVTSLSWQTSKPVIVNEKNYT- 331

  Fly   283 AEGGEVWMWSENKVLG 298
                     ||..:||
plant   332 ---------SEMALLG 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup43	NP_650716.2	WD40 repeat	16..73	CDD:293791	6/30 (20%)
		WD40	74..347	CDD:295369	53/244 (22%)
		WD40 repeat	77..125	CDD:293791	19/58 (33%)
		WD40 repeat	133..166	CDD:293791	6/32 (19%)
		WD40	<142..344	CDD:225201	34/165 (21%)
		WD40 repeat	173..211	CDD:293791	6/39 (15%)
		WD40 repeat	222..263	CDD:293791	13/42 (31%)
		WD40 repeat	266..291	CDD:293791	3/28 (11%)
NEDD1	NP_001119176.1	WD40	46..>326	CDD:225201	53/252 (21%)
		WD40	46..325	CDD:295369	53/251 (21%)
		WD40 repeat	48..100	CDD:293791
		WD40 repeat	138..174	CDD:293791	12/35 (34%)
		WD40 repeat	182..218	CDD:293791	12/55 (22%)
		WD40 repeat	267..305	CDD:293791	12/38 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910