DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup43 and AT4G30840

DIOPT Version :9

Sequence 1:	NP_650716.2	Gene:	Nup43 / 42209	FlyBaseID:	FBgn0038609	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_567858.1	Gene:	AT4G30840 / 829208	AraportID:	AT4G30840	Length:	361	Species:	Arabidopsis thaliana

Alignment Length:	383	Identity:	81/383 - (21%)
Similarity:	148/383 - (38%)	Gaps:	86/383 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SEKVSQVRWLPEELQQSERFVTGSW--DMDQNFVRLWRLQSNQYVTATDSEVDQIPRCMDKVRME 74
            |:.|..|||||:....:..|.|.|:  |.|.:.:.:..|..|   ...:...:.:...:......
plant    16 SKYVDGVRWLPQASALNRFFATASYDADCDSSSIEIQSLDPN---PRGNHNTNPLIESLSSWTSP 77

  Fly    75 DDVTAMEFVD--------KDTLAVSCADGHLSVFNVH----RAVEEDQMQRTSR--SGRLHCFQR 125
            ..|:::|...        |..::.:.:.|.|.|..:.    .|:||.......|  .||:.....
plant    78 SRVSSLEVAGNGGGGGSFKPMVSAATSSGSLHVLMIDLVEGAAIEEFYAAEGERFHVGRVEGVDW 142

  Fly   126 SQEPAPCTDLSVYGTDIATAGEDGCVSIVSVENVRQVKRQIEADS---MALFSICYISQQELVTA 187
            .:           |.:..|.||||.|::|.:.|...::.:...|.   :|..::.:.|..|.||.
plant   143 RE-----------GGECVTVGEDGRVNVVKIVNGEGLRYRKVFDGNGLVAYRAVKWASPTEFVTG 196

  Fly   188 NRMGVIRMLDARVATEA--QPKTTFMVASQDDKSNFVSSLAKHPMQQHILLCGSEEGSITVWDMR 250
            .....:::.|.|.:.||  |.|..:.   |...|..|.|:..||.::|..:.|...|::..||:|
plant   197 GYGFGLQLWDQRKSGEAVSQLKGNWF---QGKTSAIVHSIDIHPSRKHTCIAGGSSGTVFAWDLR 258

  Fly   251 NLSYP--ASYLSAHK---SPINEIGFHQKDPSKLFTAAEGGEVWMWSENKVLGCDYNKDGHSPWL 310
            ....|  .|.:.|.:   :|::|                 .|||     :|....|.|..    :
plant   259 WPQQPIVLSGVGASENINNPLSE-----------------SEVW-----EVQYDSYTKSN----V 297

  Fly   311 SGDRVRSLV--DVEGVLSNVRK------------SINSFDV---HGSRLVCGGDTEAV 351
            |..|:..::  ..:|:|..:.:            :|||||:   :...::|..:.|::
plant   298 SSSRILPVMTCSEDGILGIIEQGEEPIELLAEPCAINSFDIDRQNPQDVICSLEWESI 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup43	NP_650716.2	WD40 repeat	16..73	CDD:293791	12/58 (21%)
		WD40	74..347	CDD:295369	66/313 (21%)
		WD40 repeat	77..125	CDD:293791	12/61 (20%)
		WD40 repeat	133..166	CDD:293791	9/32 (28%)
		WD40	<142..344	CDD:225201	52/228 (23%)
		WD40 repeat	173..211	CDD:293791	10/39 (26%)
		WD40 repeat	222..263	CDD:293791	13/42 (31%)
		WD40 repeat	266..291	CDD:293791	4/24 (17%)
AT4G30840	NP_567858.1	WD40	133..>268	CDD:295369	36/148 (24%)
		WD40	133..>268	CDD:225201	36/148 (24%)
		WD40 repeat	137..175	CDD:293791	9/48 (19%)
		WD40 repeat	183..223	CDD:293791	10/42 (24%)
		WD40 repeat	230..276	CDD:293791	13/45 (29%)
		WD40 repeat	284..328	CDD:293791	9/52 (17%)
		WD40 repeat	333..358	CDD:293791	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	48	1.000	Domainoid score	I4478
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I2644
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D658269at2759
OrthoFinder	1	1.000	-	-		FOG0007248
OrthoInspector	1	1.000	-	-		oto4005
orthoMCL	1	0.900	-	-		OOG6_106008
Panther	1	1.100	-	-	LDO	PTHR22652
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930