DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup43 and Nup43

DIOPT Version :9

Sequence 1:	NP_650716.2	Gene:	Nup43 / 42209	FlyBaseID:	FBgn0038609	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_663752.2	Gene:	Nup43 / 69912	MGIID:	1917162	Length:	380	Species:	Mus musculus

Alignment Length:	375	Identity:	105/375 - (28%)
Similarity:	182/375 - (48%)	Gaps:	39/375 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YISEKVSQVRWLP---EELQQSERFVTGSWDMDQNFVRLWRLQSNQYVTATDSEVDQIPRCMDKV 71
            ::|:|:|:.||.|   ..||.:|.|.|||||.::|.|.||.:.....:. :|...:...:.:..:
Mouse     8 FVSQKISKTRWRPVPSGSLQTTETFATGSWDNEENCVSLWSIGDFGNLD-SDGGFEGDHQLLCDI 71

  Fly    72 RMEDDVTAMEFVDKDTLAVSCADGHLSVFNVHRAVEEDQMQRTSRSGRLHC--FQRSQEPAPCTD 134
            |...||..::|.|::.:..:.:.|.::||..|...:...:.:...:...|.  ...|...||||.
Mouse    72 RHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWPAAHYHTGPSSPSYSSAPCTG 136

  Fly   135 LSVYGTDIATAGEDGCVSIVSVENVRQVKRQIEADSMALFSICYISQQELVTANRMGVIRMLDAR 199
            :.....:|.|.||||.:::..|::...|:....|||..|.::.::...|:||.|.:|.:::.|.|
Mouse   137 IVCDNPEIVTVGEDGRINLFRVDHKEAVRTIDNADSSTLHAVTFLRTPEIVTVNSIGQLKIWDFR 201

  Fly   200 VATEAQPKTTFMVASQDDKSNFVSSLAKHPMQQHILLCGSEEGSITVWDMRNLSYPASYLSAHKS 264
                .|......:.|.......:..:.:||.|||::..|.::|.:::||:|..:.|.|.|.||::
Mouse   202 ----QQGSEPCQILSLTGDRVPLHCVDRHPDQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEA 262

  Fly   265 PINEIGFHQKDPSKLFTAAEGGEVWMWS------ENKVLGCDYNKDGH----------------- 306
            .:.|:.||..:|..|||.:|.|.:|.|.      |...|   :::.|.
Mouse   263 EMWEVHFHPSNPDHLFTCSEDGSLWHWDASTDAPEKSSL---FHQGGRSSTFLSHSLSNQAGVHQ 324

  Fly   307 ---SPWLSGDRVRSLVDVEGVLSNVRKSINSFDVHGSRLVCGGDTEAVYL 353
               |.|||.|..:..:::..:|.:...|:||.||.|..||||.|.||:|:
Mouse   325 SLVSSWLSTDPAKDRIEITSLLPSRTLSVNSLDVLGPCLVCGTDAEAIYV 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup43	NP_650716.2	WD40 repeat	16..73	CDD:293791	18/59 (31%)
		WD40	74..347	CDD:295369	80/300 (27%)
		WD40 repeat	77..125	CDD:293791	8/49 (16%)
		WD40 repeat	133..166	CDD:293791	9/32 (28%)
		WD40	<142..344	CDD:225201	63/227 (28%)
		WD40 repeat	173..211	CDD:293791	9/37 (24%)
		WD40 repeat	222..263	CDD:293791	14/40 (35%)
		WD40 repeat	266..291	CDD:293791	10/24 (42%)
Nup43	NP_663752.2	WD 1	8..57		19/51 (37%)
		WD 2	72..110		8/37 (22%)
		WD40	73..>306	CDD:295369	64/260 (25%)
		WD40 repeat	78..133	CDD:293791	12/56 (21%)
		WD 3	119..166		14/48 (29%)
		WD40 repeat	138..168	CDD:293791	9/29 (31%)
		WD40	<144..374	CDD:225201	68/234 (29%)
		WD 4	170..208		9/37 (24%)
		WD40 repeat	175..212	CDD:293791	8/36 (22%)
		WD 5	215..255		11/39 (28%)
		WD40 repeat	220..258	CDD:293791	12/37 (32%)
		WD 6	259..299		15/45 (33%)
		WD40 repeat	266..303	CDD:293791	13/42 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843260
Domainoid	1	1.000	169	1.000	Domainoid score	I3793
eggNOG	1	0.900	-	-		E1_KOG4714
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11639
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4123
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59409
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007248
OrthoInspector	1	1.000	-	-		oto92997
orthoMCL	1	0.900	-	-		OOG6_106008
Panther	1	1.100	-	-	LDO	PTHR22652
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3018
SonicParanoid	1	1.000	-	-		X7163
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790