DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup43 and SPAC1A6.02

DIOPT Version :9

Sequence 1:	NP_650716.2	Gene:	Nup43 / 42209	FlyBaseID:	FBgn0038609	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_001342873.1	Gene:	SPAC1A6.02 / 3361484	PomBaseID:	SPAC1A6.02	Length:	361	Species:	Schizosaccharomyces pombe

Alignment Length:	327	Identity:	67/327 - (20%)
Similarity:	136/327 - (41%)	Gaps:	66/327 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 KVRMEDDVTAMEFVDKDTLAVSCADGHLSVFNVHRA----VEEDQMQRTSRSGRLHCFQRSQEPA 130
            |.:.|:::..:....::.:.:..::|.:|.:....|    ||:...:|..:|
pombe    10 KQKFENEIFDLACFGENQVLLGFSNGRVSSYQYDVAQISLVEQWSTKRHKKS------------- 61

  Fly   131 PCTDLSV--YGTDIATAGEDGCVSIVSVENVRQVKRQI--EADSMALFSICYISQQELV--TANR 189
             |.::||  .||:..:.|.||.:.|......|...:.|  :...::.:|:....:.::|  |.:.
pombe    62 -CRNISVNESGTEFISVGSDGVLKIADTSTGRVSSKWIVDKNKEISPYSVVQWIENDMVFATGDD 125

  Fly   190 MGVIRMLDARVATEAQPKTTFMVASQDDKSNFVSSLAKHPMQQHILLCGSEEGSITVWDMRNLSY 254
            .|.:.:.|.|  ||..     ::.:.:|..:::||::  |.::...:..|.:|.::|.|.||...
pombe   126 NGCVSVWDKR--TEGG-----IIHTHNDHIDYISSIS--PFEERYFVATSGDGVLSVIDARNFKK 181

  Fly   255 PASYLSAHKSPINEIGFHQKDP-SK-------------LFTAAEGGEVWMWSENKVLGCDYN--- 302
            |  .||..:......|...:|. ||             |||..:.|:......:.:...|::
pombe   182 P--ILSEEQDEEMTCGAFTRDQHSKKKFAVGTASGVITLFTKGDWGDHTDRILSPIRSHDFSIET 244

  Fly   303 ---KDGHSPWLSG-DRVRSLVDV-----EGVLS--NVRKSINSFDV--HGSRLV-CGGDTEAVYL 353
               .|..|.::.| |....|:.:     |.::.  :.|.::::.||  .|:.|| |.|...|.:.
pombe   245 ITRADSDSLYVGGSDGCIRLLHILPNKYERIIGQHSSRSTVDAVDVTTEGNFLVSCSGTELAFWP 309

  Fly   354 VD 355
            ||
pombe   310 VD 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup43	NP_650716.2	WD40 repeat	16..73	CDD:293791	1/2 (50%)
		WD40	74..347	CDD:295369	62/313 (20%)
		WD40 repeat	77..125	CDD:293791	7/51 (14%)
		WD40 repeat	133..166	CDD:293791	9/34 (26%)
		WD40	<142..344	CDD:225201	48/236 (20%)
		WD40 repeat	173..211	CDD:293791	8/39 (21%)
		WD40 repeat	222..263	CDD:293791	12/40 (30%)
		WD40 repeat	266..291	CDD:293791	8/38 (21%)
SPAC1A6.02	NP_001342873.1	WD40	5..>314	CDD:225201	67/327 (20%)
		WD40 repeat	17..54	CDD:293791	5/36 (14%)
		WD40 repeat	64..99	CDD:293791	9/34 (26%)
		WD40 repeat	109..146	CDD:293791	8/43 (19%)
		WD40 repeat	151..185	CDD:293791	10/37 (27%)
		WD40 repeat	193..239	CDD:293791	8/45 (18%)
		WD40 repeat	242..278	CDD:293791	6/35 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22652
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010