DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup43 and npp-23

DIOPT Version :9

Sequence 1:	NP_650716.2	Gene:	Nup43 / 42209	FlyBaseID:	FBgn0038609	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_501537.2	Gene:	npp-23 / 182462	WormBaseID:	WBGene00007493	Length:	371	Species:	Caenorhabditis elegans

Alignment Length:	375	Identity:	86/375 - (22%)
Similarity:	157/375 - (41%)	Gaps:	62/375 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 STHYISE-------KVSQVRWLPEELQQSERFVTGS------WDMDQNFVRLWRLQSNQYVTATD 58
            ||..:.|       |:|::.:..|...|......|.      |:.|..      :...:.:...:
Worm    24 STPLVDEIMQHADVKLSKILFTGETSSQIISLGKGRGRCISLWERDDG------IDPFKVLATKN 82

  Fly    59 SEVDQIPRCMDKVRMEDDVTAMEFVDKDTLAVSCADGHLSVFNVHRAVEEDQMQRTSRSGRLHCF 123
            ||:|....|    .|.|          :.:.:..|||.|:||    :.::|.:...||...:|..
Worm    83 SEIDPNDAC----TMTD----------NRVCIGYADGSLAVF----STDKDDLALMSRIPSIHSG 129

  Fly   124 QRSQEPAPCTDLSVYGTDIATAGEDGCVSIVSVENVRQVKRQIEADSMALFSICYISQQELVTA- 187
            ..|::      :..:|..|.:|..:|  |:|:|:....:.|.|......:.|:|......:|.|
Worm   130 SASRK------ICRHGNSILSASSNG--SLVAVDVETGMPRTIFTGQAGIRSVCTTFGTNVVMAG 186

  Fly   188 NRMGVIRMLDARVATE----AQPKTTFMVASQDDKSNFVSSLAKHPMQQHILLCGSEEGSITVWD 248
            :..|.|.|.|.|...|    ..|..|.:.:.:  ..:.|::|..||.|.:::.||:::|.:.:.|
Worm   187 DANGQITMWDLRENNEHSNTLDPIKTLIPSKK--ALDAVTALCSHPAQSNLVCCGTDDGIVGLID 249

  Fly   249 MRNL---SYPASYLSAHKSPINEIGFHQKDPSKLFTAAEGGEVWMWSENK---VLGCDYNKDGHS 307
            .||:   :..::||.|.|: |:::.||.|....|..::..|.:.....:.   .:|....||  :
Worm   250 ARNVRGANITSTYLVAKKA-ISQVMFHPKCGDNLLVSSNDGSLIRIDASGAPIAVGPRSTKD--T 311

  Fly   308 PWLSGDRVRSLVDVEGVLSNVRKSINSFDVHGSRLVCGGDTEAVYLVDNI 357
            .||.||.|.|| .::.:.:....||:|||:....:|.......:.|...:
Worm   312 IWLEGDLVNSL-RLDPIRNESVHSISSFDIRSDTVVTASSIGLISLYQQL 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup43	NP_650716.2	WD40 repeat	16..73	CDD:293791	10/62 (16%)
		WD40	74..347	CDD:295369	70/283 (25%)
		WD40 repeat	77..125	CDD:293791	10/47 (21%)
		WD40 repeat	133..166	CDD:293791	8/32 (25%)
		WD40	<142..344	CDD:225201	56/212 (26%)
		WD40 repeat	173..211	CDD:293791	12/42 (29%)
		WD40 repeat	222..263	CDD:293791	14/43 (33%)
		WD40 repeat	266..291	CDD:293791	6/24 (25%)
npp-23	NP_501537.2	WD40	20..357	CDD:225201	85/370 (23%)
		WD40	96..>329	CDD:295369	63/250 (25%)
		WD40 repeat	133..166	CDD:293791	9/40 (23%)
		WD40 repeat	171..208	CDD:293791	10/36 (28%)
		WD40 repeat	223..264	CDD:293791	12/40 (30%)
		WD40 repeat	269..294	CDD:293791	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162788
Domainoid	1	1.000	67	1.000	Domainoid score	I6415
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	68	1.000	Inparanoid score	I3931
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311838at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto17204
orthoMCL	1	0.900	-	-		OOG6_106008
Panther	1	1.100	-	-	LDO	PTHR22652
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3018
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.930